Understanding Post-Transcriptional Sex Differences in Neurological Disease

Here we propose to build upon compelling evidence we have uncovered suggesting that RNA-binding proteins (RBPs) regulate their targets in a sex-specific manner. This discovery indicates the presence of unique regulatory mechanisms governing gene expression and cellular function in the male and female brain that are as of yet unexplored. To elucidate these mechanisms, our study employs a multifaceted approach. We will investigate behavioral and molecular changes in both mouse models and human neurons in order to reveal the intricate network of interactions underlying sex-specific vulnerability to neurological disorders. By dissecting the molecular pathways involved, we aim to better understand the differences between male and female brain physiology and to gain valuable insights into sex-specific vulnerabilities in neurological disorders. Furthermore, our findings hold the potential to inform the development of targeted therapeutic interventions tailored to address the distinct needs of male and female patients. Project Number: 1R21NS142727-01A1 | Fiscal Year: 2026 | NIH Institute/Center: National Institute of Neurological Disorders and Stroke (NINDS) | Principal Investigator: Vincenzo Gennarino (+1 co-PI) | Institution: COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY | Award Amount: $250,328 | Activity Code: R21 | Study Section: Molecular Neurogenetics Study Section[MNG] View on NIH RePORTER: https://reporter.nih.gov/project-details/11304943