Sustained release of VRC07 from capsule-intravaginal ring for preventing HIV transmission

The goal of this SBIR Research Topic is to support small businesses in the development of devices and/or materials for administration of HIV-1 bNAb(s) and bNAb derivatives with the end goal of increasing protection from infection. The goal of this contract is to develop an intravaginal ring (IVR) with capsules releasing the long-acting bNAb VRC07-523LS to leverage the phenomenon of muco-trapping, whereby immunoglobulins trap pathogens in mucosal tissues. Project Number: 75N93025C00021-0-9999-1 | Fiscal Year: 2025 | NIH Institute/Center: National Institute of Allergy and Infectious Diseases (NIAID) | Principal Investigator: Keiichiro Kushiro | Institution: MUCOMMUNE, LLC, Morrisville, NC | Award Amount: $306,183 | Activity Code: N43 View on NIH RePORTER: https://reporter.nih.gov/project-details/75N93025C00021099991