Polarity dysregulation in Alzheimer’s disease

/Abstract This is an administrative supplement application to the parent grant to support the purchase of a new microscope system due to the unexpected failure of a critical component in our existing system. Due to the age of the existing microscope, manufacturing of the failed parts was discontinued, and newer alternatives are incompatible with the existing system. Attempts to source used parts have proved challenging, and reliance on microscopes in other laboratories or shared facilities have been inadequate, which has delayed our progress on the proposed aims because of limited scope access and other practical limitations detailed in the application. These factors underscore the need for a sustainable solution as our proposed aims rely heavily on high resolution confocal microscopy. This equipment breakdown was entirely unanticipated during grant submission and reporting periods, precluding any rebudgeting from existing funds to adequately address the loss of independent high- resolution imaging capacity. As such, an administrative supplement is requested, with the institution committing matching funds in order to fully cover the cost of the new imaging system. Several imaging systems are considered, and the proposed solution represents the most cost-effective way to restoring full research productivity. Project Number: 3RF1NS130881-01A1S1 | Fiscal Year: 2026 | NIH Institute/Center: National Institute of Neurological Disorders and Stroke (NINDS) | Principal Investigator: Huaye Zhang | Institution: RUTGERS BIOMEDICAL AND HEALTH SCIENCES, Newark, NJ | Award Amount: $50,000 | Activity Code: RF1 View on NIH RePORTER: https://reporter.nih.gov/project-details/11469950