Nerve Artificial Intelligence (NerveAI) and High-Resolution Magnetic Resonance Neurography: Advancing the Diagnosis and Treatment of Headache Disorders

Project Summary This common ON biomarkers. intelligence-based electronic optimize custom-designed nerve detecting entrapments. we of outcomes, and headache improving headache application outcome project aims to improve the diagnosis and treatment of occipital neuralgia (ON), a but underrecognized cause of headache disorders. Currently, the diagnosis of is challenging due to the lack of specialized clinical expertise and objective i maging To address these gaps, we will further develop NerveAI, an artificial algorithm capable of accurately identifying nerve pain patterns from pain drawings in real time at the initial point of care. Concurrently, we will high-resolution magnetic resonance neurography (MRN) techniques using coils and deep learning image reconstruction techniques to visualize pathology with high accuracy. We will establish tandardized MRN protocols for abnormalities such as nerve enlargement, hyperintensity, and structural By integrating NerveAI pain pattern analysis with MRN imaging biomarkers, aim to create a comprehensive diagnostic framework that enhances early detection ON. This combined approach will also enable the prediction of surgical treatment guiding personalized interventions. We will evaluate the diagnostic accuracy predictive power of these tools in a prospective cohort of patients presenting with symptoms. This project will facilitate timely, objective diagnosis of ON patient outcomes, reducing healthcare costs, and advancing understanding of pathophysiology. The innovations developed here have the potential for broad across peripheral nerve and headache disorder diagnostics and treatment prediction. s Project Number: 1R01NS148851-01 | Fiscal Year: 2026 | NIH Institute/Center: National Institute of Neurological Disorders and Stroke (NINDS) | Principal Investigator: Lisa Gfrerer | Institution: WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY | Award Amount: $702,655 | Activity Code: R01 | Study Section: Special Emphasis Panel[ZRG1 NICD-H (01)] View on NIH RePORTER: https://reporter.nih.gov/project-details/11347158