MANUFACTURING PROCESS DEVELOPMENT OF 4-HB

The overall objective of this project is for the contractor to support the chemistry, manufacturing, and controls (CMC) development of 4-HB. The objectives of this study are: 1. The contractor shall develop a manufacturing process for 4-hydroxybenzoic acid (4-HB) based on the suggested scheme (1,2, and 3) and develop a cost and operation-efficient process for generating GMP batch 4-HB. 2. The contractor shall perform analytical development to release 4-HB and detect all related impurities. 3. The contractor shall perform a long-term stability study on 4-HB. Project Number: 75N91019D00024-0-759102500018-1 | Fiscal Year: 2025 | NIH Institute/Center: National Cancer Institute (NCI) | Principal Investigator: lynn briscoe | Institution: LEIDOS BIOMEDICAL RESEARCH, INC., FREDERICK, MD | Award Amount: $917,706 | Activity Code: N01 View on NIH RePORTER: https://reporter.nih.gov/project-details/11456815