Limited Competition: Outcomes of Electronic Medical Records and Genomics (eMERGE) Genomic Risk Assessment and Management Network - Clinical Sites (U01, Clinical Trial Required)

<p>The National Human Genome Research Institute (NHGRI) intends to promote a new initiative by publishing a Notice of Funding Opportunity (NOFO) to solicit applications for research to extend follow-up and collection of outcome data for the 25,000 participants receiving genomically informed risk assessment (GIRA) and management recommendations in the Electronic Medical Records and Genomics (eMERGE) Network. This multi-site continuation of the eMERGE Genomic Risk Assessment and Management Study will: 1) extend follow-up of eMERGE participants from a minimum 1 year to at least 4 years; 2) assess longer-term adherence to and outcomes of GIRA-based preventative recommendations among clinicians and participants; and 3) identify correlates of adherence by condition, participant age and demographics, and other non-genomic factors. We plan to issue an RFA for the coordinating center as a single source and the clinical sites as a limited competition.</p><p><br></p><p>This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The NOFO is expected to be published in 2025 with an expected application due date in 2025. This NOFO will utilize the U01 activity code.</p>