Human-mouse chimera model of neuroHIV

The dynamics of HIV infection in the brain is poorly understood. Infected cells that transport HIV across the blood brain barrier and into the brain causes inflammation and subsequent damage to resident brain cells. This manifests as a group of symptoms collectively referred to as HIV associated neurocognitive deficits (HAND). Today, in the post ART era, HAND consists of mild to moderate symptoms. This research is significant because it uses an in vivo model to assess the unique interactions among brain cells and peripheral immune cells in vivo in an HIV infected ASRT treated model. Results from these studies will give a better understanding of the events that define neuroHIV in the ART era. Project Number: 1R61MH144575-01 | Fiscal Year: 2026 | NIH Institute/Center: National Institute of Mental Health (NIMH) | Principal Investigator: Jennillee Wallace | Institution: RUSH UNIVERSITY MEDICAL CENTER, CHICAGO, IL | Award Amount: $1,518,208 | Activity Code: R61 | Study Section: Special Emphasis Panel[ZNS1 SRB-U (08)] View on NIH RePORTER: https://reporter.nih.gov/project-details/11239261