Development of antimicrobials based on principles of induced proximity

Small molecules have been classically developed to inhibit enzyme activity; however, new classes of small molecules that endow new functions to enzymes via proximity-mediated effect are emerging. Most of these chimeric molecules have been developed in the context of cancer. We propose to build chimeric molecules that recruit the immune system to bacteria. These molecules will be formed by joining together binders of proteins of the complement system and binders of bacteria and exhaustively characterized using biochemical, biophysical, and cell biology experiments. 1 Project Number: 1R21AI190536-01 | Fiscal Year: 2025 | NIH Institute/Center: National Institute of Allergy and Infectious Diseases (NIAID) | Principal Investigator: Amit Choudhary | Institution: BROAD INSTITUTE, INC., CAMBRIDGE, MA | Award Amount: $481,250 | Activity Code: R21 | Study Section: Chemical Biology and Probes Study Section[CBP] View on NIH RePORTER: https://reporter.nih.gov/project-details/1R21AI19053601