Determinants of reservoir contraction and expansion in vivo, ex vivo, and in vitro

RELEVANCE (See instructions): Our proposal studies why HIV reservoirs decay at different rates in various cohorts of HIV-infected individuals on antiviral therapy. We hypothesize that reservoir contraction and expansion occur simultaneously in all HIV-infected individuals making the reservoir appear stable. We propose to perturb these forces and use a machine learning analysis to identify the drivers behind them and to ultimately reduce the size of the HIV reservoir. Project Number: 5R37AI150556-07 | Fiscal Year: 2026 | NIH Institute/Center: National Institute of Allergy and Infectious Diseases (NIAID) | Principal Investigator: Una O'Doherty | Institution: EMORY UNIVERSITY, ATLANTA, GA | Award Amount: $648,378 | Activity Code: R37 | Study Section: NSS View on NIH RePORTER: https://reporter.nih.gov/project-details/5R37AI15055607