Defining the structure-interactome relationships of the basigin glycoprotein in endometriosis

Endometriosis is characterized by the extraneous presence of endometrial cells outside the uterine organ. The molecular mechanisms governing the migration of endometrial cells and the corresponding regulators of endometriosis are yet to be known, leaving critical gaps in the search for targets that can be used to treat endometriosis. We have recently found that an N-linked glycoprotein called basigin contributes to endometriosis. Here, we will apply proximity labeling technologies to define the interactome of basigin in cell culture models of endometriosis. Given the density of glycan post-translational modifications on basigin, we also reason that N-linked glycosylation can contribute to its interactome. The resulting interactomes will be used to define how basigin is regulating endometriosis and also open new potential targets for intervention. Project Number: 1R21HD119928-01 | Fiscal Year: 2025 | NIH Institute/Center: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Principal Investigator: Mia Huang | Institution: SCRIPPS RESEARCH INSTITUTE, THE, LA JOLLA, CA | Award Amount: $506,000 | Activity Code: R21 | Study Section: Chemical Biology and Probes Study Section[CBP] View on NIH RePORTER: https://reporter.nih.gov/project-details/1R21HD11992801