Complete Mental Counts for Patients Recovering from Brain Injury

1/ This project seeks to commercialize MindCount: a computerized assessment aid based on visuotactile measures of mental functioning to inform interventions for neurocognitive disorders after traumatic brain injury (TBI), akin to how complete blood counts inform interventions for immune disorders following infections. Inertial forces during TBI insults, such as rapid head acceleration-deceleration, can cause diffuse axonal injury throughout the brain, disrupting networks that control everyday mental functioning. There is a strong need for sensitive and accessible tools to monitor mental functioning and patient recovery. MindCount is a clinical decision support tool for prioritizing intervention targets and monitoring treatment response across neurobehavioral conditions, from neurocognitive to mood disorders. In research settings, MindCount can help elucidate dynamic interactions between mental domains and dimensions, from Movement Initiation and Dynamics in the Reflexive domain to Attention and Planning in the Cognitive domain. The ultimate benefits are actionable assessment reports that support timely and personalized interventions, leading to better patient outcomes and lower societal costs. 2/ Innovations in human-computer interaction enable exceptionally sensitive and highly accessible assessment of mental functioning based on spatiotemporal analyses of finger slides, tracks, and tap sequences. MindCount is deployable to any touchscreen device via software-as-a-service subscriptions, facilitating rapid distribution. A prior NSF SBIR project produced a test battery prototype and found systematic psychometric mappings, such as slower reactions given higher cognitive load. A subsequent clinical study found large case-control differences across MindCount measures, indicating clinical feasibility. 3/ This project aims to expand, validate, and productize MindCount as an aid for monitoring patient recovery. The proposed case-control studies are designed to verify the claims that MindCount can assess and monitor changes in mental dysfunction. Phase I will focus on post-TBI inpatients while Phase II will study them as they progress from inpatient to outpatient care. The primary success metric is large case-control differences across MindCount measures—as quantified by effect sizes—indicating clinically meaningful efficacy. Secondary success metrics include high usability, good test-retest reliability, and significant associations with reference tests, including patient outcomes. Target users and buyers have expressed enthusiastic interest. Project Number: 1R44NS143670-01 | Fiscal Year: 2025 | NIH Institute/Center: National Institute of Neurological Disorders and Stroke (NINDS) | Principal Investigator: Ran Carmi | Institution: EYE-PREDICT, LLC, LOS ANGELES, CA | Award Amount: $497,201 | Activity Code: R44 | Study Section: Special Emphasis Panel[ZRG1 CCHI-G (10)] View on NIH RePORTER: https://reporter.nih.gov/project-details/11186797