Funding Organization
National Institute on Aging
802 opportunities
About
No description available for this funder.
Grants (802)
Research and Education in Alzheimer’s Disease and Dementias Initiative for Excellence (READDIE)
open$428,410 - $428,410
Imaging Core
open$135,499 - $135,499
SORL1 and its involvement in Alzheimer's disease pathogenesis and pathophysiology - Project 1: Characterizing the structural biology of SORL1 variants
open$369,511 - $369,511
The influence of ovarian hormones and age on prefrontal encoding of episodic fear memories
open$424,875 - $424,875
Dysregulated ovulatory debris clearance as a driver of ovarian fibroinflammaging
open$400,000 - $400,000
Gene Therapy for Non-Motor Defects in Synucleinopathy
open$452,375 - $452,375
Engineering a Human Glial-Neuronal Microphysiological System to Study Myelination and Axonal-Synaptic Pathology in Alzheimer's Disease
open$486,750 - $486,750
Time-Efficient Inspiratory Muscle Strength Training for Reducing Sympathetic Activity and Improving Sleep in Midlife Women
open$439,258 - $439,258
Multimodal Optical Imaging and AI Analytics to Uncover APOE4 Etiology and Therapeutic Targets in Late Onset Alzheimer's Disease
open$636,372 - $636,372
Ketogenic Approach to Restore Muscle in older patients with community-Acquired Pneumonia - KARMA-P Trial
open$409,750 - $409,750
Long-Term Effects of Ransomware Attacks on Rural and Safety-Net Hospitals
open$573,566 - $573,566
From Cells to Society: Using Epigenetics to Understand Brain Vulnerability to Delirium and Cognitive Decline
open$761,496 - $761,496
Elucidating the Relationship Between Tau Accumulation, White Matter Degeneration, and Cognition in preclinical Alzheimer Disease.
open$129,876 - $129,876
Long-term Implications of Early Life Exposure to the US Public Housing Program
open$679,589 - $679,589
Deciphering the Impact of Oral Hypofunction, Dysphagia, and the Airway Microbiome on Pneumonia Pathogenesis in Older Adults
open$646,358 - $646,358
Neural circuit basis of age-related changes in female social behavior
open$326,550 - $326,550
Job Opportunities and Obstacles in ICU Survivors (JOBS-ICU)
open$673,771 - $673,771
2026 Kern Lipid Conference; Lipids and lipoproteins in Neurodegenerative and Cardiometabolic disease
open$41,700 - $41,700
Evaluating software usability to identify barriers to community pharmacists' use and to improve Medication Therapy Management adoption for older adults
open$346,500 - $346,500
Integrating Medicare and Medicaid for Dual Eligibles with Disabilities: Evaluating the Impact on Utilization, Quality, Mortality, and Chronic Diseases Management
open$720,523 - $720,523
Epac1 Signaling Promotes Retinal Neuronal Injury During Tauopathy
open$617,349 - $617,349
Occupation and Labor Force Participation across the Life Course: Implications for Cognitive Functioning in Later Life
open$317,000 - $317,000
Deciphering the contribution of the aged alveolar niche to lung cancer evolution
open$463,375 - $463,375
Multiorgan Photon Counting CT and Machine Learning to Elucidate Aging Mechanisms and Interventions
open$612,746 - $612,746
Microbial regulation of type 2 immunity in ovarian tissue remodeling and fibrosis
open$681,020 - $681,020
Boston University-Demographic and Social Determinants of Healthy Cognitive Aging Research Program (BU-SHARP)
open$465,607 - $465,607
Understanding the impact of caregiver involvement in older adult healthcare visits: Opportunities for targeted interventions
open$144,500 - $144,500
Chromatin Signaling Mechanisms in Metabolic Aging and Disease
open$542,730 - $542,730
Identifying neurobehavioral mechanisms of rhythmic cues for speech-in-noise perception
open$44,691 - $44,691
16th International Conference on Brain Energy Metabolism: Preserving Cellular Energetics and Brain Function in Aging and Neurological Disease
open$50,000 - $50,000
Personalizing Post Surgical Thromboprophylaxis for Elderly Patients with Peripheral Artery Disease
open$802,936 - $802,936
Molecular Reprogramming of Microglia in Neurodegeneration
open$34,114 - $34,114
Characterizing phenotypes of chronic disease among people aging with HIV in the United States
open$450,928 - $450,928
A Randomized Trial of REFRAME: an Emotion Regulation Intervention to Improve Psychological Outcomes in Surrogate Decision-Makers of the Critically Ill
open$659,056 - $659,056
Role of Autophagy in skeletal diseases
open$487,847 - $487,847
Immunometabolic regulation of inflammaging by nerve-associated macrophages
open$544,318 - $544,318
Investigating retrotransposon-derived products as a source of tau-mediated neuroinflammation
open$55,114 - $55,114
Psychosocial Stress in Early Life, Chronodisruption and Accelerated Aging in Mid Life: A Life-course Approach
open$646,620 - $646,620
54th Annual Meeting of the American Aging Association
open$50,000 - $50,000
Biobehavioral Signatures of Repetitive Head Impacts at the Intersection of Aging and Alzheimer's Disease
open$439,739 - $439,739
Vaginal estradiol versus moisturizer to improve postmenopausal vaginal aging symptoms, dysbiosis and markers of HIV latency reversal in menopausal women living with HIV
open$706,734 - $706,734
Effect of caloric restriction on aging biomarkers, frailty, and multimorbidity in older adults
open$3,157,326 - $3,157,326
Novel Retinal Biomarker Development in Early Alzheimer's Disease
open$405,955 - $405,955
Environmental Modulation of Behavioral and Molecular Aging in Genetically Identical Mice
open$136,350 - $136,350
Beta3-adrenergic receptors and cardiovascular function in aging women
open$433,125 - $433,125
Delineating systemic roles of APOE genotypes on CNS health
open$2,944,007 - $2,944,007
Legacy effects of randomization to caloric restriction and exercise on bone strength in older adults: a pooled analysis
open$417,545 - $417,545
Roles of Misfolded Protein Aggregates on Latent Reservoirs in SIV-infected, ART-treated Aged Rhesus Macaques
open$422,125 - $422,125
Clonal Hematopoiesis of Indeterminate Potential in Aging and Exceptional Longevity in Older Women
open$785,867 - $785,867
Selective vulnerability of the locus coeruleus and hypothalamus to HSV-1 infection in Alzheimer's disease progression
open$442,485 - $442,485
Cellular Thermogenesis and Lifespan Modulation: Mechanisms of Cold-Temperature Aging in Drosophila
open$429,000 - $429,000
ABMR Annual Meeting 2026 & 2027
open$49,500 - $49,500
Impact of GLP-1 Receptor Agonists on Sarcopenia in Older Adults
open$436,228 - $436,228
A systems-level analysis of DNA damage and repair in senescence, aging and cancer
open$723,962 - $723,962
Beyond Today: Building a Federated Infrastructure for Lifespan Health and Disease Research
open$711,747 - $711,747
Unraveling the longitudinal effects of lifelong inulin supplementation on the metabolic pathophysiology of aging
open$76,848 - $76,848
2026 Lysosomes and Endocytosis Gordon Research Conference and Gordon Research Seminar
open$39,540 - $39,540
Protein Folding in the Cell
open$45,850 - $45,850
Cell Type Specific Drug Repurposing for Alzheimer's Disease
open$1,419,145 - $1,419,145
Molecular mechanisms of neuronal cell death
open$452,783 - $452,783
Dissecting Cell Cycle Arrest Phenotypes in Aging and Age-Associated Diseases
open$438,625 - $438,625
Microvascular hemodynamics and speech function in adults at risk for Alzheimer's disease
open$624,208 - $624,208
Age-associated decline of meningeal gdT cells and their modulation by the gut-meninges axis
open$612,346 - $612,346
Voice-activated and touchscreen-controlled smart speaker intervention for adults aged 50 years and older with poorly controlled type 2 diabetes
open$195,000 - $195,000
Geroscience of sex differences SCORE (GERO SCORE)
open$1,499,966 - $1,499,966
ApoE-Tau axis in preeclampsia, a severe pregnancy complication, and neurodegeneration
open$3,267,011 - $3,267,011
Non-Autonomous Regulation of Cardiac Aging
open$523,313 - $523,313
The impact of tau on RNA and translation in progressive supranuclear palsy
open$422,125 - $422,125
National Institute on Aging Demography and Economics Coordinating Center (NIA DECC)
open$1,222,211 - $1,222,211
Development of an Oral GCPII Inhibitor for Peripheral Nerve Injury in Aging
open$597,350 - $597,350
Longitudinal hippocampal and cognitive changes in autism spectrum disorder
open$308,000 - $308,000
Longitudinal imaging in a preclinical model of Alzheimer's Disease to identify early biomarkers of cognitive decline
open$309,000 - $309,000
Changes in Hippocampal Coding of Very Large Spaces from Adulthood to Senescence
open$439,750 - $439,750
Instrumented brain organoids transplantation for chronic stroke treatment
open$649,688 - $649,688
Epigenetic age acceleration and differences among immune cell populations in people with and without HIV
open$519,500 - $519,500
Proteomic identification of nuclear rupture-associated proteins in laminopathy hearts
open$445,500 - $445,500
Cell Size Inheritance and Innate Immune Memory
open$681,277 - $681,277
Genetic Modifiers of Atherosclerosis: Understanding and Targeting the Mechanism of the ApoER2-R952Q Mutation
open$456,500 - $456,500
Age-dependent changes in primary sensory neurons and nociceptors
open$450,200 - $450,200
Elucidating the role of m6A in Fragile X-associated tremor/ataxia syndrome
open$430,375 - $430,375
K63 polyubiquitination as a mechanism linking obesity and age-related memory decline
open$409,464 - $409,464
Targeting Activin A signaling to enhance bone repair
open$723,105 - $723,105
Defining Characteristics of a Resilient Organelle Interactome During Aging
open$435,875 - $435,875
The role of Synaptojanin1 in age-dependent motor decline
open$431,750 - $431,750
Correction of VCP Disease Pathology with Antisense Oligonucleotides
open$431,750 - $431,750
Skeletal Stem Cell-based Cartilage Regeneration in Aged and Osteoarthritic Niches
open$627,212 - $627,212
Neurotoxic Astrocytes and Alzheimer's Disease
open$2,557,950 - $2,557,950
Mild Cognitive Impairment: A Prospective Community Study
open$3,831,172 - $3,831,172
Core A - Administrative and Research Support Core
open$168,638 - $168,638
Project 2: Local and global epigenome regulation of senescence and aging
open$401,404 - $401,404
Marrow adipocytes modify the neural regulation of bone
open$518,372 - $518,372
Telomere entanglements: formation, disentanglement, and impact of failed disentanglement on genome stability
open$547,371 - $547,371
Esophageal stents integrating wireless soft actuators for restoring peristalsis
open$423,142 - $423,142
Using a xenotopic approach to manipulate redox metabolism in a tissue- and compartment-specific manner to study aging
open$501,160 - $501,160
Vascular smooth muscle aging and the epigenetic clock
open$461,311 - $461,311
The interplay among reproductive, molecular, and chronological age in relation to aging-related conditions in women: a longitudinal study
open$706,310 - $706,310
Cross-Species Roles of TCER-1/TCERG1 in Fertility and Reproductive Aging
open$453,785 - $453,785
Beyond Genetics: Unveiling Epigenetic Drivers of Lifespan Heterogeneity through Yeast Single-Cell Aging Atlases
open$440,000 - $440,000
Defining the role of cell mechanics in regulating hair follicle stem cells across homeostasis and aging
open$559,795 - $559,795
Using a systems engineering, human-centered design process to integrate elements of age-friendly care into structures and processes of evidence based hospital-to-home transition interventions
open$462,341 - $462,341
Regulation of somatic aging by the hyperactive germline
open$149,000 - $149,000
Core A: Administrative and Research Support
open$133,327 - $133,327
The role of big tau in preventing tau pathology
open$225,256 - $225,256
Impact of vitamin B12 status on mitochondrial disease onset and progression
open$440,900 - $440,900
Roles for a novel component in nucleophagy and chronological aging
open$439,750 - $439,750
ASPIRE: Alzheimer’s Summer Program Inspiring Research Engagement
open$70,659 - $70,659
Understanding and targeting chromatin mechanisms of cytoplasmic chromatin fragments during senescence and aging
open$463,000 - $463,000
Cellular Pathology and Biomarkers Following Gene Delivered Tauopathy in Aged Macaque Monkeys
open$675,329 - $675,329
Impact of Nurse Practitioner Primary Care Models on Health Disparities among Persons Living With Dementia
open$452,375 - $452,375
Endogenous RNAi and aging control
open$343,350 - $343,350
Lysosome-Golgi Contact Sites as Regulators of Senescence-Associated Inflammation
open$429,000 - $429,000
SORL1 and its involvement in Alzheimer's disease pathogenesis and pathophysiology - Project 2
open$233,218 - $233,218
Regulatory Network Modeling of Cellular Transitions in Aging Epithelia and Capillaries
open$482,620 - $482,620
Immune aging and outcomes in adult survivors of childhood cancer
open$798,501 - $798,501
Decision-Making Capacity Assessment and Inclusive Decision-Making for Older Persons with Capacity Challenges
open$423,500 - $423,500
Advancing Alzheimer's Disease research through a preclinical model of SERPINA3
open$435,875 - $435,875
Optimizing High-Resolution MRI for Analyzing Perivascular Space Dynamics and Waste Clearance in Alzheimer's Disease
open$670,530 - $670,530
3D MRI Method for CMRO2 Mapping of the Brain in Dementia
open$429,498 - $429,498
Research Education Core
open$2,335,512 - $2,335,512
Olfactory Phenotypes as Non-Invasive Biomarkers for Alzheimer's Disease: A Machine Learning Approach
open$746,114 - $746,114
NICotinamidE riboside to improve functioning in PAD: The NICE Trial
open$773,538 - $773,538
Mechanisms of NBR2, a Long Non-Coding RNA, in Human Ovarian Aging
open$50,114 - $50,114
Small Research Grant Program for the Next Generation of Researchersin AD/ADRD Research
open$314,000 - $314,000
Genomics-Empowered AI for Personalized Cancer Risk Assessment, Monitoring, and Prevention
open$1,547,918 - $1,547,918
Core I - Imaging Core
open$311,601 - $311,601
Gene Therapy for APOE4 Homozygous Alzheimer's Disease
open$3,252,734 - $3,252,734
Novel biomarkers and mechanisms of Alzheimer's disease
open$643,613 - $643,613
Uncovering dynamic brain circuit mechanisms associated with apathy and disinhibition in Alzheimer's Dementia
open$423,500 - $423,500
The Effect of DDX41 Mutations on Hematopoiesis During Aging
open$645,245 - $645,245
Aging and the Health and Well-Being of New Orleans Residents Following Hurricane Katrina
open$438,625 - $438,625
Improving Functional Recovery in Skilled Nursing Facilities through Supplemental Mobility
open$396,656 - $396,656
Healthcare Readiness for Rural Older Adults with Critical Illness During Disasters
open$657,426 - $657,426
Mechanisms of Muscle Adaptations in Aging and Exercise
open$588,701 - $588,701
Age-Dependent CD7 Functions in T Cell Responses
open$41,359 - $41,359
Gut Check: The Impact of Gut Bacteria on Physical Function in Older Adults with and without HIV
open$156,000 - $156,000
Environmental Exposures and ADRD in the Health and Retirement Study Cohort
open$1,703,843 - $1,703,843
The Impact of Changes in Primary Care Clinicians' Work Effort on the Health of Older Adults
open$680,086 - $680,086
Center for AD/ADRD Population Aging and Social Studies (CAPAS) Core B - Program Development (Pilots) Core
open$207,101 - $207,101
In vivo single-cell analysis of Alzheimer's disease-associated regulatory elements
open$1,221,276 - $1,221,276
Impact of Different Classes of Osteoporosis Medications on Muscle Health in Older Adults
open$162,020 - $162,020
Spatial navigation, sex hormones, and the aging brain
open$4,765,698 - $4,765,698
FunGen-xQTL: Unraveling the genetic basis of molecular functions in Alzheimer's Disease
open$3,642,232 - $3,642,232
Genetics of exceptional resilience and its variation; insights from the world's longest-lived animal
open$1,875,196 - $1,875,196
Reciprocal Interactions Linking Cognitive Performance, Aβ aggregation, and Transcriptional Processing with Sleep Disruption in an Alzheimer's Disease Model
open$420,750 - $420,750
American Society of Biomechanics Annual Meeting 2025
open$55,000 - $55,000
Senescent CAFs in Breast Cancer Progression
open$593,410 - $593,410
Mapping Structural Brain Networks Linked to Mild Behavioral Impairment
open$156,000 - $156,000
Leadership and Administrative Core
open$2,966,725 - $2,966,725
A Scientific Retreat to Address Ethical Challenges in Data and Sample Sharing to Advance Neurodegenerative Research
open$150,000 - $150,000
An in vitro model to study the impact of systemic inflammation on the blood-brain barrier in neurodegenerative disease
open$49,538 - $49,538
Elucidating the synergistic role of tau and α-synuclein in neurodegeneration and cognitive decline through mitochondrial dysfunction
open$43,287 - $43,287
Evaluating Infection Independent Benefits of Influenza Vaccine in Older Adults Undergoing Surgery
open$310,052 - $310,052
Using microgravity to model inflammaging in complex organ chip models of heart, gut, and brain
open$1,202,427 - $1,202,427
Impacts of Social Resilience on Immunometabolic Hallmarks of Aging in Prairie Voles
open$694,172 - $694,172
Tai Chi Intervention for Geriatric Pain Syndrome
open$632,382 - $632,382
Developing cross-platform fluorescent reporters for measuring the 26S proteasome and the VCP activities
open$478,624 - $478,624
Global Alzheimer’s and Dementia Partnership to Advance Neuroscience in LMICs (GAP-ADN)
open$536,527 - $536,527
Elucidating the neuronal mechanisms underlying cognitive resilience to Alzheimer's Disease
open$167,940 - $167,940
Regulation of thymus function and aging by the sympathetic nervous system
open$462,000 - $462,000
Identifying Multi-Scale Mechanisms for Age-Related Increase in Metabolic Cost of Walking
open$3,224,215 - $3,224,215
Exercise Protection of the Aging Nervous System: Defining Exercise Impact on Cell and System
open$454,938 - $454,938
Developing a Comparative Single-Cell Spatial Transciptomic Atlas of Brain Aging in Non-Human and Humans
open$209,148 - $209,148
Emotion network dysfunction and anxiety in early Alzheimer's disease
open$132,786 - $132,786
Pain Assessment, Treatment, and Functional Outcomes in Hospitalized, Older Adults
open$183,317 - $183,317
Contribution of Biological, Physiological and Gait Mechanisms to High Metabolic Cost of Walking in Older Adults
open$650,872 - $650,872
Mentoring and Research to Help Patients with Alzheimer’s Disease and Related Dementias Experiencing Elder Mistreatment
open$212,770 - $212,770
The Longitudinal Study of Health and Ageing in Kenya (LOSHAK): A Population study of Health, Wellbeing, Economics, and AD/ADRD in Older Kenyan Adults
open$1,962,702 - $1,962,702
Vasopressin 2 receptors in the bat bladder: effects of age and biological sex on expression and function
open$162,200 - $162,200
The impact of early life stress on vascular aging
open$450,250 - $450,250
Neuromechanical Bases for the Increased Energy Cost of Walking in Aging
open$673,012 - $673,012
Epigenetic Regulation of Nuclear cGAS Activity in Aging-Related Inflammation
open$647,866 - $647,866
Cell-type-specific dysregulation and genetic control of alternative polyadenylation in neurodegeneration
open$125,901 - $125,901
UCSF Research in Alzheimer’s Disease and Dementia (RADD)
open$109,084 - $109,084
Inhaled Stressors and Lung Aging
open$667,664 - $667,664
Novel AI-driven music-based intervention to reduce behavioral and psychological symptoms for people living with dementia
open$250,812 - $250,812
Association of LOY with Other Forms of Genome Instability
open$460,849 - $460,849
Stress-Induced Aging: Investigating Chronic Wound Stress as a Catalyst for Systemic Aging and Functional Decline
open$686,700 - $686,700
Role of APP-related circRNAs induced by HIV-1 infection in beta-amyloid formation
open$435,875 - $435,875
Integrated micro-to-macro network models of disease spread in frontotemporal dementia
open$427,919 - $427,919
Tracking the life cycle of cells in senescence.
open$438,625 - $438,625
The effect of age-related changes in macrophage polarization and the post-injury immune response on fracture healing
open$393,750 - $393,750
Association of Peripheral Nerve Blocks with Postoperative Outcomes and Readmissions in Older Adults Undergoing Hip Fracture Surgery
open$388,750 - $388,750
Serious Illness Communication Among Patients with Chronic Lung Disease and Comorbid Cognitive Impairment
open$390,000 - $390,000
Kentucky Postbaccalaureate Alzheimer’s Disease Research Education Program (KYPAD)
open$418,309 - $418,309
Designing a spatial navigation intervention protocol informed by region-specific brain activation for individuals at risk for dementia
open$220,132 - $220,132
System-wide and mechanistic deconvolution of autophagy in cellular aging
open$2,208,503 - $2,208,503
Novel orthostatic vital signs measured by an earlobe wearable device
open$385,517 - $385,517
In vitro pharmacology, chronic toxicology, and embryo-fetal development studies to demonstrate safety of GSM-779690
open$1,612,640 - $1,612,640
Gut microbiota dynamics, exercise and physical function among older people with HIV
open$429,000 - $429,000
The Role of Mechanoaging in the Deterioration of Intestinal Homeostasis with Age
open$629,562 - $629,562
Comparing epigenetic, proteomic, and MRI aging clocks in sporadic and autosomal-dominant Alzheimer disease
open$128,373 - $128,373
Enhancing prognosis communication for older adults in skilled nursing facilities
open$243,000 - $243,000
Psychedelics for Older Adults with Chronic Pain
open$3,399,999 - $3,399,999
Time2Connect: An Adapted Loneliness Intervention for Older Adults with MCI or Mild ADRD in Primary Care
open$204,806 - $204,806
Improving integration of treatment burden information in primary care for older adults with multiple chronic conditions
open$107,330 - $107,330
Neuromuscular changes in the aging larynx
open$161,892 - $161,892
Neuroimaging and genetics of the glymphatic system in Alzheimer's disease
open$165,888 - $165,888
Pilot testing a culturally adapted decision aid intervention of supporting Chinese American dementia caregivers in feeding-related decisions
open$244,019 - $244,019
A Randomized, Double-Blind, Placebo-Controlled Study of LHP588 in Subjects with P. gingivalis-Positive Alzheimer's Disease
open$12,591,952 - $12,591,952
Age-related changes to the senescence associated secretory phenotype of thyroid tissue in papillary thyroid carcinoma
open$383,750 - $383,750
Life’s end Benefits of CannaBidiol and TetrahYdrocannabinol (LiBBY) Open-Label Extension (OLE) Study
open$2,072,617 - $2,072,617
Modeling effects of cadmium exposure on Alzheimer’s Disease pathology and neurodegeneration
open$2,862,804 - $2,862,804
The role of orosomucoid1 in skeletal muscle aging during an optimized autophagy activity intervention
open$530,469 - $530,469
Opportunistic use of existing chest CT data for frailty screening
open$242,846 - $242,846
Targeting Aging-Related Delays in Cognitive Recovery After Anesthesia by Attenuating Oxidative Stress: Implications for Alzheimer's Disease
open$385,000 - $385,000
A calvarial stem cell mediating a new bone-brain axis in Alzheimer's disease
open$134,325 - $134,325
Improving Postsurgical Cognitive Outcomes in Limited English Proficient Older Adults with a Perioperative Care Partner Program: A Pilot Pragmatic Randomized Controlled Trial
open$243,000 - $243,000
The Impact of Biological Age on Surgical Outcomes
open$423,750 - $423,750
Chronic sleep disruption is a stressor for healthspan and lifespan
open$785,348 - $785,348
Leading equitable research in Alzheimer's disease in Africa (LEAD Africa)
open$201,339 - $201,339
CD4 Th1 and TCM as Modulators of Neuroinflammation
open$437,250 - $437,250
Engineering Synthetic Biomolecular Condensates for Targeted Autophagy Modulation
open$506,000 - $506,000
Targeting a novel inter-tissue L-BAIBA/FGF23 axis to enhance adaptive musculoskeletal remodeling in aging
open$3,126,515 - $3,126,515
USF Health Expanding Research in AD/ADRD Post-baccalaureate Research Education Program
open$366,985 - $366,985
Ambient Outdoor Heat and Alzheimer's Disease and Related Dementias Risk: A Biopsychosocial Approach to Vulnerability in Older Adults
open$107,946 - $107,946
Preclinical efficacy of an APOE targeted antibody for Alzheimer's disease
open$498,709 - $498,709
CRP: Noninvasive brain stimulation for chronic pain treatment
open$2,055,669 - $2,055,669
Interplay between biological aging and neuropsychiatric phenotypes after trauma
open$640,742 - $640,742
Feasibility, Acceptability, and Preliminary Efficacy of an HIV Prevention Intervention for Older Black Women
open$128,654 - $128,654
Impact of Local vs. Systemic Senescent Bone Cell Accumulation on Healthy Osteocyte Mechanosensation
open$146,070 - $146,070
Traumatic Brain Injury, Social Relationships, and Risk of Dementia
open$75,052 - $75,052
Exploiting accelerated aging associated with Low Earth Orbit (LEO) environment to gain insights into pathogenesis and treatment of progressive neurological disorders
open$2,815,841 - $2,815,841
AI-driven Drug Discovery Targeting Cardiac Fibrosis in Aging Heart
open$900,195 - $900,195
Navigating the Transition to Middle Age in the Strong African American Healthy Adults Project (SHAPE)
open$660,434 - $660,434
Neuropalliative care research
open$173,730 - $173,730
Pen-and-Paper and Smartphone Self-Reported Cognitive Concerns to Predict Longitudinal Alzheimer's Biomarkers in a Diverse, Non-Demented Older Adult Population
open$336,000 - $336,000
Polycomb Repressive Complexes and Chromatin Architecture in Cellular Aging of the Brain
open$388,648 - $388,648
Elucidating the structure function relationship between TPP1 and telomere length control through deep scanning mutagenesis
open$413,385 - $413,385
Understanding the effect of aging on the lung adenocarcinoma tumor microenvironment
open$463,625 - $463,625
Decoupling reproductive and somatic aging using novel C. elegans technology
open$472,793 - $472,793
Developing and validating natural language processing tools for memory assessment
open$440,000 - $440,000
Rescue T cell aging to improve CAR T cell production for elderly cancer patients
open$451,000 - $451,000
Study to Understand Participant Perspectives On Respite upTake (SUPPORT)
open$320,000 - $320,000
Strengthening Clinical Support for Providers Working with Women Living with HIV to Manage Menopause
open$131,598 - $131,598
Preserving Ability through Virtual Exercise (PAVE): An Intervention to Increase the Physical Activity of Hospitalized Older Adults
open$120,858 - $120,858
The Effects of Declining Nursing Home Capacity on Post-Acute and Long-Term Care Access and Health Outcomes among Older Adults and their Caregivers
open$641,856 - $641,856
Comprehensive Biological Data in NCHAT BIO: Chronic Stress, Inflammation, and Epigenetic Aging
open$1,391,989 - $1,391,989
Aging and Telomere Dysfunction in the Intestinal Stem Cell Niche
open$333,116 - $333,116
Advancing cross-disease comparisons through FAIR data practices to uncover shared molecular mechanisms between Alzheimer's disease and autoimmune disorders
open$437,469 - $437,469
Indoles from commensal microbiota promote mobility during aging
open$3,251,767 - $3,251,767
Reactive oxygen species as early-in-life modulators of lifespan
open$2,991,725 - $2,991,725
Statistical Machine Learning to Develop Connectome-Based Biomarkers of Alzheimer's Disease and Related Dementias
open$3,080,520 - $3,080,520
Discovery and Trial Ready Cohort for Limbic Predominant Age Related TDP-43 Encephalopathy (TRC LATE)
open$3,128,129 - $3,128,129
Sense4Safety Intervention
open$613,823 - $613,823
Pathogenesis of Postoperative Cognitive Dysfunction
open$723,765 - $723,765
Monitored Anesthesia Care and Soft Tissue Infiltration with Local Anesthesia for Older Adults with Hip Fracture: A Multi-Center Feasibility Randomized Clinical Trial
open$705,726 - $705,726
The Ante-Amyloid Treatment of Alzheimer's disease (A3) Trial and Alzheimer Plasma EXtension (APEX) Study
open$6,467,513 - $6,467,513
Genetic and Environmental Sources of Heterogeneity in Alzheimer's Disease: A Pathway Specific Approach
open$49,538 - $49,538
Role of m6A RNA Modifications in Microglial Dysfunction and Alzheimer's Disease Pathogenesis
open$839,933 - $839,933
TREM2 activation by vitamin D3 in the pathogenesis of Alzheimer's disease
open$43,420 - $43,420
Genetic insight into senescence from the Drosophila brain
open$446,875 - $446,875
The ANKosome: a cytoplasmic activation platform for caspase-2
open$463,916 - $463,916
Understanding the Selective Mechanism of Tau Propagation in Alzheimer's Disease Through Multi-layer Spreading Pathways
open$420,119 - $420,119
Decoding the Heterogeneity of Interneuron Vulnerability in Aging and Alzheimer's Disease: An Ultraplex CLEM Approach
open$438,625 - $438,625
Addressing emotional distress in dyads of persons with a Young Onset Dementia (YOD) and their care-partners
open$3,379,666 - $3,379,666
Connecting surgical stress to sex-dependent vulnerabilities in aging and aging hallmarks
open$699,344 - $699,344
Inhibition of Abeta42 aggregation by helix stabilizing peptidomimetic biomaterials
open$3,297,926 - $3,297,926
Evaluation of the neuroimmune mechanisms influencing therapeutic targetingpotential of the LH/CG receptor in the menopausal and AD brain
open$2,329,970 - $2,329,970
Social Engagement and Well-Being in the Final Five Years of Life
open$171,943 - $171,943
Outcomes after Hospital Discharge to Home Versus Discharge to a Facility for Older Patients with Alzheimer’s Disease and Alzheimer’s Disease Related Dementias
open$2,709,669 - $2,709,669
Dyadic Health Consequences of Distress in Patients and their Partners After an Acute Cardiovascular Event
open$3,273,481 - $3,273,481
Small Molecule Ligands Targeting Pathological Tau Signaling In AD And Related Dementias
open$3,336,256 - $3,336,256
Advancing the Study of Personality, Interpersonal Stress, and Cognitive Aging Through The Use of Integrative Data Analysis
open$3,132,978 - $3,132,978
Molecular Mechanisms and Genetic Basis of Human Ovarian Aging
open$3,445,585 - $3,445,585
Parent-child transmission of trauma in a longitudinal cohort: impact on aging-related mental and physical health well-being
open$3,355,744 - $3,355,744
Age-related deficits in episodic memory for the content and structure of naturalistic events
open$2,631,670 - $2,631,670
The Nexus of Trained Immunity and Stable Immune Complexes: Implications for Aging-Related Conditions in PLWH
open$782,648 - $782,648
Unveiling Novel Mechanisms Governing Organelle-Dependent Quality Control of Tail-Anchored Membrane Proteins
open$49,538 - $49,538
Mediators and Moderators of Executive Function Training in Older Adults
open$655,325 - $655,325
Uncovering a role for S-nitrosylated phospholipase D3 in the microglial and neuronal pathophysiology of Alzheimer's disease
open$42,596 - $42,596
Housing, Health, and Disability: The Role of Housing Assistance and Housing Insecurity among Older Adults of Low-Income
open$126,900 - $126,900
Web Application Use to Support Language and Communication in Primary Progressive Aphasia
open$49,538 - $49,538
Genetic Mapping of m6A and Pseudouridine RNA Modifications in the Aging Human Brain and Their Impact on Alzheimer's Disease
open$852,273 - $852,273
Efficacy and Mechanisms of a Metacognitive Strategy Intervention for Parkinson disease-related Cognitive Decline
open$771,627 - $771,627
Leadership and Administrative Core (LAC)
open$141,652 - $141,652
Evaluating clinical and pathological markers of cognitive decline and Alzheimer's dementia in long-duration type 1 diabetes.
open$629,622 - $629,622
A mixed methods pre-implementation study of a trauma-informed care intervention for hospitalized patients with serious illness
open$37,800 - $37,800
Mechanisms of microglial-mediated sex-based differences in tauopathy
open$48,351 - $48,351
Preparing to optimize a multimodal adaptive intervention for physical activity behavior change among middle age and older adults
open$75,052 - $75,052
Single Cell Foundation Model enabled drug discovery for clonal hematopoiesis
open$1,013,072 - $1,013,072
Impact of Age-Related Clonal Hematopoiesis on Alzheimer's Disease
open$486,750 - $486,750
Addressing the Complex Driving Continuum: Needs of an Aging Population
open$49,917 - $49,917
Cerebral Pulsatility as a Mechanism of Accelerated Cerebrovascular Aging across the Menopause Transition
open$405,155 - $405,155
The Effect of Low Volume Sprint Interval Training on Cardiorespiratory Fitness; A Randomized Controlled Trial
open$442,590 - $442,590
NEK7 suppresses inflammation in the aging heart through regulation of RNA binding proteins
open$437,375 - $437,375
Calcium Pyrophosphate Deposition Disease Development and Biochemical Pathways for Molecular Modulation.
open$225,000 - $225,000
Unique Considerations in the Older Patient Considering Surgical Management of Primary Hyperparathyroidism
open$415,000 - $415,000
Arrays of bottomless picowells for the analysis of biological age using high-resolution imaging
open$498,366 - $498,366
Implications of long-range Mossy Cell signaling and connectivity in AD
open$426,674 - $426,674
Mapping amyloid, tau, and neurodegeneration markers with neuropsychiatric phenotypes and genotypes in Alzheimer's disease continuum using machine learning
open$3,188,901 - $3,188,901
Immunological bases of the beneficial effects of exercise on skeletal muscle aging
open$190,374 - $190,374
Tracking brain structural trajectories for early detection and prognosis of Alzheimer's Disease
open$142,607 - $142,607
Environmental Exposures and Brain Health
open$5,164,012 - $5,164,012
Assessing the Role of Sex-Specific Genetic Drivers of Cerebrovascular Disease in the Alzheimer's Disease Brain
open$3,531,593 - $3,531,593
Advanced Imaging and Assistive Devices to Uncover and Address Novel Mechanisms of Age-Related Mobility Deficits
open$76,638 - $76,638
Vagus nerve modulation of hippocampus function.
open$49,538 - $49,538
Policing, Housing, and Health Outcomes in Older Homeless Adults
open$676,516 - $676,516
Characterizing concordance in the secretome of recessive dystrophic epidermolysis bullosa and cellular senescence
open$37,697 - $37,697
Genetic dissection of mitonuclear interactions in aging and neurodegenerative disease
open$610,836 - $610,836
Investigating in vivo neuronal endolysosomal dynamics in health and aging using C. elegans
open$42,507 - $42,507
Topological Machine Learning to Characterize Higher-Order Brain Connectivity Alterations in Alzheimer's Disease
open$49,538 - $49,538
Defining the Role of Collagen XII in Regulating Skeletal Muscle and Tendon during Aging
open$49,538 - $49,538
Identifying Cell Type-Specific RNA Expression and Regulatory Changes in Entorhinal Cortex Clinical Samples of Alzheimer's Disease
open$49,538 - $49,538
Tox-AD: a new multi-institute tri-consortium data resource in the AD Knowledge Portal
open$435,881 - $435,881
Collaboration, Communication, and Coordination Center for ADSP (ADSP-4C)
open$1,594,366 - $1,594,366
Dysfunctional mechanisms of the mitochondrial redox-sensitive signaling response to exercise in aged skeletal muscle
open$120,573 - $120,573
A beneficial persistent DNA damage-induced immune response in aging
open$3,101,237 - $3,101,237
Benefits and Harms of Antihypertensive Management Strategies for Nursing Home Residents with ADRD
open$2,612,229 - $2,612,229
Digital Health Technologies for Monitoring Motor Function in Progressive Supranuclear Palsy and Dementia with Lewy Bodies
open$5,174,076 - $5,174,076
Promoting stress-resilience prevents AD-associated neuropsychiatric symptoms
open$3,548,990 - $3,548,990
Interneuron circadian rhythms and tau-dependent network excitability in Alzheimer's disease pathogenesis
open$40,828 - $40,828
Understanding the Health and Health Insurance Enrollment of Gig Workers
open$566,883 - $566,883
Regulation of microglial lipid metabolism and immune functions by SHP-1 in Alzheimer's disease
open$38,945 - $38,945
tRNA fragments and their role in tau pathology in Alzheimer's disease and tauopathies
open$3,672,952 - $3,672,952
Mapping genetic vulnerability to oxidative stress in development and its consequences in age-associated cognitive decline using a novel reduced complexity rat model
open$3,078,607 - $3,078,607
Enhancer AAV-based genetic access and manipulation of specific brain cell types implicated in aging and Alzheimer's Disease
open$2,220,145 - $2,220,145
Development of an In-Home Sensory Training Therapy to Mitigate Falls Risk Among the Elderly
open$740,698 - $740,698
Adapting Machine Learning Approaches to Identify a Robust Measure and Key Risk and Protective Factors of Change in Allostatic Load across the Adult Lifespan
open$126,640 - $126,640
Impact of Taxane Chemotherapy on Gait Performance in Older Women: Does Executive Function Matter?
open$189,486 - $189,486
Understanding how sphingolipid metabolism regulates mitochondrial maintenance in aging cells
open$34,960 - $34,960
Mechanistic association of epigenetic bone age and frailty measures with bone imaging studies using novel artificial intelligence approaches
open$149,889 - $149,889
Immunologic and Imaging studies with TNF Therapy in Prodromal Synucleinopathies
open$2,361,361 - $2,361,361
The role of chronic migraine as an early biomarker of Alzheimer's Disease
open$317,000 - $317,000
The Amyloidosis Forum: Cross Stakeholder Working Group Projects to Accelerate Drug Development in AL and ATTR Amyloidosis
open$49,300 - $49,300
Out-of-pocket spending and burdensome care for older adults with serious illness
open$422,500 - $422,500
Cascade Amplification Biosensor Technology for Detecting MicroRNA Biomarkers of Alzheimer Disease
open$426,555 - $426,555
TMEM106B and Mitochondrial Dysfunction in FTLD and Other Dementia
open$310,083 - $310,083
Reverse electron transport inhibition to suppress fibroblast activation in aging
open$460,283 - $460,283
Mobility Matters: Advancing Care in Skilled Nursing Facilities Conference
open$70,491 - $70,491
Genetics and therapeutics pinpoint link between glucose metabolism and Alzheimer’s disease
open$75,520 - $75,520
Targeting T follicular helper cells for rejuvenating the aging germinal center
open$127,019 - $127,019
Investigating Senolytic Properties in Pulmonary Rehabilitation and Metformin in COPD Exacerbations (INSPIRE-COPD-E).
open$243,000 - $243,000
Center for Seniors Uniting Nationwide to Support Health, INtegrated care, and Economics (SUNSHINE)
open$463,318 - $463,318
Clustering of Rehospitalization Risk Factors and Identification of Associated Home Health Interventions in Aging Sepsis Survivors Receiving Home Healthcare
open$51,038 - $51,038
BeFitMe II: Applying User-Centered Co-Design and Implementation Science to Enhance Prehabilitation for Frail Older Adults Undergoing Lung Cancer Surgery
open$243,000 - $243,000
Investigating glial priming by an early-life sensory experience
open$54,538 - $54,538
Investigating Vulnerable Cell Populations in Aging-Induced Circadian Clock Remodeling and Disruption
open$54,538 - $54,538
Virtual Reality-Based Cognitive Stimulation Games for Enhancing Attention and Preventing Delirium in Older Surgical Patients with Cognitive Impairment: A Randomized Controlled Pilot Trial
open$242,840 - $242,840
The Proteomic Signature of Dual Decline in Gait and Cognition
open$242,489 - $242,489
Identifying palliative care needs among nursing home residents with and without Alzheimer's Disease and related dementias
open$145,043 - $145,043
Senescent Cells Effects in Response to Pathogens
open$124,875 - $124,875
HIV, ART and aging: Role of Lactate in NeuroHIV
open$750,000 - $750,000
Digital speech markers for early detection of Alzheimer’s disease in a longitudinal racially and ethnically diverse cohort
open$4,591,694 - $4,591,694
Apoptotic Dysregulation Across Cell Types in Aging and Neurodegeneration
open$132,472 - $132,472
Differentiating chronic sleep disruption from intermittent hypoxia in OSA on tau pathology and spread
open$464,750 - $464,750
SCH: Novel Multi-View Statistical Machine Learning for Alzheimer's Disease
open$1,012,879 - $1,012,879
FOXO3 dependent proinflammatory transcription program of AD
open$475,377 - $475,377
The Impact of Frailty on Disease Relapse and Therapy Intensity in Older Adults with Acute Myeloid Leukemia: Biomarkers and Treatment Selection
open$243,000 - $243,000
Characterizing and predicting comorbidity cascade among men and women with and without HIV by harnessing data from MWCCS and electronic medical records
open$428,493 - $428,493
Investigating a novel vascular pathway that regulates neuronal survival
open$473,592 - $473,592
Exploring heterogeneity of cognitive trajectories of preclinical Alzheimer's disease with digital phenotyping
open$327,000 - $327,000
The combination of anti-amyloid therapy and rTMS for AD
open$398,046 - $398,046
Body composition, physical activity, and cognitive function in Down syndrome
open$77,752 - $77,752
Development and Pilot Testing of an Electronic Health Record-based Serious Illness Communication Intervention for Older Adults in the Emergency Department
open$191,193 - $191,193
Development and pilot testing of a novel text messaging intervention to improve emergency department care transitions among care partners of persons living with cognitive impairment
open$242,902 - $242,902
Leadership Training in Real-World Data Analytics: Sleep and Alzheimer's Disease
open$149,148 - $149,148
Deciphering the molecular landscape of frontotemporal lobar degeneration: A network-based proteomic approach
open$200,182 - $200,182
Bridging Gaps to Translate Plasma Alzheimer's Disease Biomarkers to Diverse Populations
open$163,080 - $163,080
Evaluating the effect of a new Medicare dental benefit on the health of older adults
open$242,196 - $242,196
Strengthening Recovery - Integrating Intrinsic Capacity Care into Post-Acute Skilled Nursing Facilities
open$243,000 - $243,000
Digital Accessible Remote Olfactory Mediated Health Assessments for Lewy Body Disease
open$493,964 - $493,964
Manufacturing of ABCA1 agonist small molecule peptide CS6253 to support chronic toxicology studies in Wistar rats and Cynomolgus monkeys
open$2,454,521 - $2,454,521
Passive cognitive assessment across the menopausal transition
open$399,999 - $399,999
TauTrace™: An ultrasensitive immunoassay for neurodegenerative protein biomarkers
open$499,940 - $499,940
FIND-seq: A Novel Cell Sorting Technology to Enable Investigation of Rare Cells in Primary Human Tissues
open$306,871 - $306,871
Clarifying the interplay between herpesvirus infection and reactivation, immune responses, APOE genotype, and development of tau-pathology
open$3,280,861 - $3,280,861
Bioenergetic Contributions to Tau Phosphorylation in Aging and Alzheimer Disease
open$38,596 - $38,596
Examining Unique Markers and Risk Factors for AD/ADRD in Foreign- and Native-born Older Chinese Americans: A Study of Social Determinants of Health, Sleep Patterns, Neuroimaging, and Plasma Biomarkers
open$4,035,962 - $4,035,962
Bridge to Belonging (B2B): Peer led intervention to reduce loneliness and depression among older gay and bisexual men
open$443,875 - $443,875
Sleep Slow-Wave Activity as a Potential Vulnerability and Modifiable Risk Factor: Examining the Relationship from Chronic Stress to Accelerated Aging and Alzheimer's Disease
open$612,005 - $612,005
Phthalates, oxidative stress, and hot flashes in aging women
open$445,719 - $445,719
Geriatric depression in India: Inadequate access to water and sanitation as risk factors
open$126,404 - $126,404
Deciphering the role of CD44 astrocytes in Alzheimer's disease
open$2,957,210 - $2,957,210
tRNA Epitranscriptome and Translational Dysfunction in ADRD
open$801,569 - $801,569
Characterizing white matter injury in Alzheimer's disease
open$1,001,700 - $1,001,700
The Impact of BBTI on Cognition and Sleep Health in Older Adults with HIV
open$715,977 - $715,977
Biological drivers of sex differences in frontotemporal dementia
open$3,427,292 - $3,427,292
Senescence induced by iron overload in the brain vasculature
open$417,800 - $417,800
Exploring Serious Illness Communication between Latino Spanish-Speaking Older Adults and Community-Based Palliative Care Clinicians
open$412,500 - $412,500
Rescuing Visual Perception in Aging Adults by Restructuring the Alpha-Gamma Neural Code
open$343,350 - $343,350
Adipocyte-Derived Lipid and Mitochondrial Signals in Neuroprotectionand Brain Senescence
open$2,586,818 - $2,586,818
The development of an RT-qPCR Assay for early diagnosis of Alzheimer's Disease
open$483,346 - $483,346
Investigating how hippocampal place cell coding is affected by APOE4 homozygosity
open$425,986 - $425,986
The impact of estrogen hormone therapy modality on urobiome dynamics in postmenopausal women
open$458,616 - $458,616
Interfacility transfer of older adults: outcomes and opportunities for improving patient-centered care
open$388,750 - $388,750
Lineage-Traced Single-Cell Analysis of Epigenetic Clocks
open$528,000 - $528,000
Determining if Tregs are Dysfunctional in Alzheimer's Diseases
open$492,250 - $492,250
Peripheral immunity and the aging brain: Studying the relationship of platelet and neutrophil activity with markers of vascular contributions to cognitive decline and dementia
open$1,552,000 - $1,552,000
ReCARDO: Using Real-World Data to Derive Common Data Elements for Alzheimer's Disease and AD-Related Dementias Research Through Ontological Innovation
open$3,995,531 - $3,995,531
Impact of Undiagnosed Dementia on Healthcare Utilization Across Geographic Regions.
open$2,528,708 - $2,528,708
Developing a performance-based measure of daily function for screening Hispanic/Latino older adults for Alzheimer's disease risk
open$2,465,320 - $2,465,320
Urban heat island exposure and its impact on Alzheimer’s disease and related dementia outcomes among older adults in South Florida
open$777,041 - $777,041
Development of Platelet-Derived Exercise Mimetics as a Treatment for Alzheimer's Disease and Alzhimer's Disease Related Dementias
open$506,198 - $506,198
Influence of Interpersonal Connectedness in Spousal Care Dyads on Early Progression of AD
open$3,240,750 - $3,240,750
H3IT: Home Healthcare, Hospice, and Information Technology Conference
open$49,964 - $49,964
The Role of Neighborhood Social Exposome Dynamics in Risk and Resilience to Alzheimer's Disease and Related Dementias
open$3,039,714 - $3,039,714
The Volunteering-in-Place Program for Apathetic Assisted Living Residents with ADRD
open$405,137 - $405,137
Role of the Retrosplenial Cortex in the Progression of AD Pathogenesis in Mouse and Human
open$3,221,450 - $3,221,450
Measuring social needs among older adults: psychometrics and policy
open$2,776,875 - $2,776,875
AI-Enhanced and Culturally Adapted STAR-C for Latino Caregivers: A Stage I Pilot Study
open$2,208,923 - $2,208,923
A role for mitochondrial AMPK signaling in neurons
open$2,602,940 - $2,602,940
Hypothalamic Pathways of Age Related Homeostatic Dysregulation
open$2,591,620 - $2,591,620
tRNA modifications regulating mitochondrial function and the mitochondrial proteome in AD/ADRD
open$781,008 - $781,008
Mechanisms of tubular lysosome induction in animal health and longevity
open$1,565,823 - $1,565,823
Trans Spinal Delivery of Targeted Exosomal Formulation of Curcuminoids to Treat AD
open$506,434 - $506,434
Advancing women’s care in Alzheimer’s disease and other dementias through EHR
open$3,377,863 - $3,377,863
Optimizing validity of comparative effectiveness research in Alzheimer's disease and related dementias using large language models
open$3,687,278 - $3,687,278
Precise Wearable System for Accurate Continuous Gait Monitoring to Indicate Health Decline in Black Adults with Alzheimer's Disease and Related Dementias
open$499,943 - $499,943
Improving Self-Care of Caregivers of Adults in Homecare with Heart Failure and Cognitive Impairment
open$585,710 - $585,710
Restoring Cognitive Function through Precision Neurostimulation: A Disease-Agnostic Approach Based on Convergent Hippocampal Dynamics.
open$547,998 - $547,998
The Dementia Datahub: Building a Long-term Surveillance Infrastructure to Support Transdisciplinary Research and Stakeholder Collaboration
open$610,942 - $610,942
Caring for Dementia Caregivers in Ethnic Immigrant Communities
open$736,747 - $736,747
Establishing an Alzheimer’s disease biomarker clock in Down syndrome using positron emission tomography and plasma analytes
open$1,346,873 - $1,346,873
Defining short RNA therapeutics that combat TDP-43 proteinopathy connected to AD and ADRDs.
open$3,360,074 - $3,360,074
Early Life Adversity, Cumulative Life Stress, and Cellular Aging in Midlife Women and Offspring
open$3,304,237 - $3,304,237
Pre-clinical development of a small molecule therapeutic for the systemic treatment of idiopathic pulmonary fibrosis
open$943,301 - $943,301
Implementation Strategies for a Pharmacist-Led Community-Based Care Transition Program for Rural Older Adults with Dementia and their Care Partners
open$422,319 - $422,319
Complex III-derived reactive oxygen species in mitochondrial-nuclear crosstalk in Alzheimer's disease and related dementias
open$740,075 - $740,075
Bone-Targeted Nanoparticles to Accelerate Fracture Healing in Aging Populations
open$886,403 - $886,403
Circuit vulnerability of the lateral and medial entorhinal cortices in tauopathy models of Alzheimer's disease
open$2,489,452 - $2,489,452
Democratizing Early Detection and Longitudinal Monitoring of Alzheimer's Disease: An Ultra-Sensitive Blood-Based Assay
open$506,061 - $506,061
Impact of m6A RNA modifications in Alzheimer's disease and tauopathies
open$805,573 - $805,573
RNA modifications leading to pathophysiological translation of circRNAs in AD
open$595,769 - $595,769
Epigenetic modulations by sleep to mitigate neurodegeneration
open$125,000 - $125,000
Housing policy, neighborhood context, and pathways to midlife mortality in a social experiment
open$2,501,173 - $2,501,173
Goals of Care Addressing Disparities and Variation for Alzheimer's Disease Nursing Home Care at End of Life
open$843,404 - $843,404
Regulated cGAS activation in HSV-1-associated neuropathogenesis.
open$3,354,022 - $3,354,022
Mitochondria-Nuclear Communication via Lactylation in Alzheimer’s Disease
open$555,501 - $555,501
Intervention to promote communication quality of life for persons with language‐led dementia and their partners: A randomized pilot trial
open$856,024 - $856,024
Nicotinamide Adenine Dinucleotide Augmentation to Prevent or Reverse the Progression of Alzheimer's Disease in People with Down Syndrome
open$801,359 - $801,359
Knowledge and Interpersonal Skills to Develop Enhanced Relationships (KINDER): Testing the Efficacy of an Intervention to Prevent Psychological Elder Abuse in Family Caregiving
open$688,414 - $688,414
A druggable mito-nuclear feedback mechanism that preserves mitochondrial and synaptic function in old-age
open$878,190 - $878,190
Capturing social and cognitive health dynamics as digital risk biomarkers of Alzheimer's disease
open$3,424,229 - $3,424,229
circRNAs as markers of life stress and experience during aging
open$437,795 - $437,795
Microvascular endothelial lipid metabolism as a target for age-related vascular cognitive impairment
open$286,000 - $286,000
Longitudinal Quality of Life and What Matters Most to Older Adults with Indolent Non-Hodgkin Lymphoma
open$420,000 - $420,000
Does extracellular tau modulate neurogenesis via LRP1?
open$433,125 - $433,125
Access to Medications to Treat Opioid Use Disorder in the Medicare Population
open$683,222 - $683,222
Alzheimer's Disease in Native Hawaiians and Pacific Islanders: Sample Acquisition and Whole Genome Sequencing
open$2,738,965 - $2,738,965
Adding Residential Address History Data to Project Talent: Unveiling the Long-Term Effects of Neighborhood Characteristics on Cognitive Risk and Resiliency
open$417,296 - $417,296
Catestatin regulation of tauopathy and its therapeutic potentials
open$405,625 - $405,625
Glymphatic MR Imaging and Biomarker Discovery in Aging with HIV Infection
open$629,712 - $629,712
The Progeria Research Foundation 12th Annual International Scientific Workshop: Coming of Age - Progeria Research Reaching for the Cure
open$98,625 - $98,625
WECARE: A personalized intervention for underserved Chinese American dementia caregivers
open$677,026 - $677,026
Missed Home Health Care in Older Adults with Dementia: Identifying Drivers, Outcomes, and Costs
open$627,916 - $627,916
The influence of estrogen on the thermoregulatory responses to heat stress in pre and postmenopausal women
open$40,985 - $40,985
Impact of circulating levels of endocrine disrupting toxicants on cognition, brain activity and Alzheimer's disease biomarkers across the menopausal transition
open$4,055,366 - $4,055,366
Neurocognitive Dysfunction in Adrenal Cortisol Insufficiency
open$419,321 - $419,321
Neural Mechanisms underlying the benefits of Aerobic Exercise in Advanced Parkinson's disease
open$665,118 - $665,118
The Microvascular Aging Effects - Women's Evaluation of Systemic aging Tenacity in Heart, Brain and Frailty (MAE-WEST HBF) ("You are never too old to become younger!")
open$1,497,502 - $1,497,502
Interdisciplinary Infrastructure for Aging Research: Establishing the Lucidity in Alzheimer’s and Dementia (LEAD) Network
open$758,049 - $758,049
SORL1 and its involvement in Alzheimer's disease pathogenesis and pathophysiology - Genetics Core
open$280,999 - $280,999
WHIM (Women's Health in Menopause): Promoting healthy aging in menopausal women
open$399,813 - $399,813
Orexins and severity of menopausal symptoms in mice
open$432,250 - $432,250
Improving Cardiometabolic Health with Meditative Movement in Mobility Impaired Women
open$659,376 - $659,376
Efflux Route Responses of Cerebral Waste Clearance During Progression of Alzheimer’s Disease
open$3,062,355 - $3,062,355
Epitranscriptomic Regulation of Microglia in Alzheimer's Disease
open$509,413 - $509,413
Amyloid-mediated cognitive dysfunction in bacterial pneumonia after TBI
open$2,663,195 - $2,663,195
Human neuropeptide transmitter systems are dysregulated in Alzheimer's disease pathogenesis
open$3,138,871 - $3,138,871
Moderation of Aging Trajectories of Cognition and Neuropathology by Diet Composition in Middle-aged Nonhuman Primates
open$6,424,607 - $6,424,607
Developing Novel Ambroxol Analogs as Disease-Modifying Therapies for Alzheimer's Disease and Related Dementias
open$496,600 - $496,600
Characterizing neurocognitive deficits in post-acute sequelae of COVID-19
open$365,227 - $365,227
A Comparative Analysis of Age Differences in Social Networks
open$207,032 - $207,032
State-dependent gating of memory and plasticity in the aging brain
open$107,097 - $107,097
Scaling a network of small community-based care homes as a high-value alternative to institutional care
open$1,089,329 - $1,089,329
Human iPSC neural spheroids to screen for compounds that block tau propagation
open$1,245,237 - $1,245,237
Assessing the impact of floods and federal policies on older adult mortality:leveraging Bayesian, quasi-experimental, and agent-based modelingtechniques
open$49,538 - $49,538
Using Natural Language Processing and Speech Processing Techniques to Understand and Predict Cognitive Decline
open$43,404 - $43,404
CFTR and Vascular endothelial function
open$427,625 - $427,625
Thermoregulatory Physiology of Menopausal Hot Flashes
open$628,753 - $628,753
Clonal hematopoiesis, epigenetic changes, social determinants of health, and behavioral risk factors as predictors of accelerated aging in HIV
open$703,644 - $703,644
Anti-Fibrogenic Therapy to Target Aging-Associated Urethra Dysfunction
open$431,750 - $431,750
International Workshops to Grow and Support Global Network of Interdisciplinary Researchers Fluent in Neurology, Brain Imaging, Epidemiology, Genetics, Multiomics, and Ethics
open$50,000 - $50,000
Cerebral Small Vessel Disease and Brain Health in an Indigenous African Cohort (cSVD-IAC)
open$487,582 - $487,582
Ecological Cognitive Monitoring through AI-Enhanced Personal Photo Activities
open$499,686 - $499,686
Investigating Neurosciences, a Summer Program to Ignite Research and Education (INSPIRE)
open$215,998 - $215,998
Restoring Self-Feeding with a Sensor Driven Robotic System
open$306,872 - $306,872
An Internet of Things Automated Cognitive Behavioral Therapy for Insomnia that Improves Cognition in Older Adults
open$499,963 - $499,963
Best Practices for the Measurement and Analysis of Cognitive Data in the International Health and Retirement Study (HRS) Family and its Harmonized Cognitive Assessment Protocol (HCAP)
open$375,539 - $375,539
An Eyedrop Diagnostic Test for Alzheimer's Disease
open$493,384 - $493,384
Advancing cross-national research on aging and cognitive function: English/Spanish courses with the Mexican Health and Aging Study and HRS/HCAP global partner studies
open$366,354 - $366,354
M4: Modules on advanced Methodology when Modeling Multinational data
open$344,164 - $344,164
Addressing Pressure Injury Disparities in Persons with Darkly Pigmented Skin Using Dynamic Tissue Simulations
open$313,311 - $313,311
STAGE TRIALS: Stage-model Training Approaches for Guiding Effective Translation of behavioral Research Interventions in Aging TriaLS
open$377,280 - $377,280
Primate epigenetic and senescence biomarkers to advance aging science and anti-aging strategies.
open$291,913 - $291,913
Development of a Drug Candidate for the Treatment of Agitation in Alzheimer's Disease
open$495,699 - $495,699
Flourish All: Women's Integrated Stress Reduction for Alzheimer's Risk Prevention Using Digital Tools and Biomarker Monitoring
open$474,092 - $474,092
Single domain antibody development for improving vascular dysfunction in Alzheimer’s disease
open$1,237,522 - $1,237,522
Entrepreneurship & Science Communication for Aging and Aging-related Research (ESCAAR) Program for Doctoral Students and Postdoctoral Scholars
open$269,025 - $269,025
Targeting aVb8 integrin to restore astrocyte-microglia crosstalk to treat Alzheimer's disease
open$254,896 - $254,896
Development of novel epigenetic biomarkers and detection reagents for aging
open$1,249,682 - $1,249,682
Commercialization Readiness of an Intraoperative EEG-Guided Precision Anesthesia Management System to Prevent Postoperative Delirium in Elderly and Patients at Risk for Alzheimer's & Related Dementia
open$1,998,482 - $1,998,482
Monell Scientist Entrepreneurial Program for Healthy Aging (MSEP-HA)
open$260,188 - $260,188
Innovating a Personalized Reinforcement Interface to Motivate Engagement (PRIME) Among Care Partners for People Living with Alzheimer's Disease and Related Dementia in their Communities
open$499,396 - $499,396
A Primary Care eConsult Platform for Dementia Diagnosis and Care Management
open$497,782 - $497,782
Identification of next generation gamma-secretase modulators for Alzheimer's disease
open$258,213 - $258,213
Brain-Wide Quantification of Blood-Brain Barrier Penetrating Antibody Therapeutics
open$1,400,651 - $1,400,651
AD04 disease-modifying drug for Alzheimer's - preclinical and IND-enabling studies
open$1,249,957 - $1,249,957
Imaging of Neurovascular Response for Assessment of Alzheimer's Disease
open$500,000 - $500,000
Creation of Dynamic, Non-Stochastic, W Function Informed Methylation Risk Scores (MRS) for Diagnostic/Therapeutic Applications
open$320,511 - $320,511
Zinnia All Day: An application for mobile devices and connected TVs to assist care partners promote routine in activities of daily living in persons with Alzheimer's Disease and Related Dementias
open$499,898 - $499,898
Novel Therapy for Sarcopenia
open$354,000 - $354,000
Validation of APT101 for the Treatment of Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD) in an Aging Murine Model
open$279,513 - $279,513
System to Allow Off Site Monitoring of Pressure Ulcers for Patients in a Rural Long-Term Care Facility
open$499,921 - $499,921
INCLUDE Clinical Researcher Training (ICRT)
open$866,506 - $866,506
Evaluation of ViewMind's ability to detect beta-amyloid and tau burden consistent with Alzheimer's disease in persons with MCI using Machine Learning, VR, and eye-tracking technology
open$495,731 - $495,731
Imaging intracerebral and systemic T cell immunity in patients with Alzheimer's disease using 18F-F-AraG
open$871,261 - $871,261
SynG: a Music-Based Intervention for Alzheimer's and Mild Cognitive Impairment
open$467,538 - $467,538
The SoundMind Smart Amplifier: An affordable, accessible, user-friendly hearing solution for persons with memory concerns and their family caregivers
open$499,993 - $499,993
Elucidating the Influence of Ovarian Aging and Endocrine Shifts on Spatial Navigation, as an Early Diagnostic Target for Alzheimer's Disease
open$44,418 - $44,418
A Novel, AI-Enabled Dementia Care Agent to Reduce Disparities for Rural ADRD Care Partners.
open$499,651 - $499,651
CaringGPT: Empowering Dementia Caregivers with Personalized and Accessible Resources to Match Their Needs, Enhance Cope with Caregiving, and Reduce Stress
open$499,938 - $499,938
Novel Educational Programs and Tools for Increasing Uptake of the NIH Stage Model in Behavioral Intervention Development
open$377,622 - $377,622
Strengthening Bonds: A Telephone Reminiscence Intervention to Reduce Social Isolation and Improve Mental Health in Rural Older Adults
open$817,959 - $817,959
Developing a digital and generative AI tool to improve participation in AD/ADRD trials
open$499,778 - $499,778
Research and Education in Alzheimer's Disease and Dementias Initiative for Equity (READDIE)
open$428,410 - $428,410
Scalable cGMP production of SV2A PET tracers using photoredox chemistry for applications in clinical trials and early AD diagnosis
open$499,844 - $499,844
Behavioral Shifts in Dementia Patients Using Novel Pharmacy Home Robotics: A Cost-Effective Approach to Aging in Place
open$1,240,765 - $1,240,765
Postbaccalaureate Alzheimer's Disease Development Initiative (PADDI)
open$307,801 - $307,801
Improving Neurological Health with Acetylcholine via Neuroplasticity-based Computerized Exercise in Mild Cognitive Impairment (INHANCE-MCI)
open$1,006,653 - $1,006,653
Implementing a tech platform for training & consumer access to nanny agency sourced caregivers; a nascent elder companion care workforce
open$306,872 - $306,872
Phase I STTR: Targeting substrate of gamma-secretase for selective amyloid reduction in Alzheimer’s Disease
open$252,124 - $252,124
New Nanoprobes for MR Imaging of TrkB in Alzheimer's Disease
open$499,588 - $499,588
Development of Advanced Analytical Tools Integrating External Datasets with MoTrPAC Data:Utilizing Statistical, Machine Learning, and AI Approaches to Uncover Molecular Mechanisms of Physical Activity
open$71,168 - $71,168
Validating Terra, a device for closed-loop hot-flash cooling relief and sleep improvement
open$277,391 - $277,391
YayaGuide: AI-Enabled Personalized Training for Caregivers of Older Adults with ADRD
open$505,042 - $505,042
Real-time head motion monitoring for all clinical MR sequences using Universal FIRMM
open$699,964 - $699,964
RAISE-Botswana: Research on Aging, AD/ADRD, and Its Social Determinants in Botswana
open$215,509 - $215,509
Preclinical validation of a novel adjunct small molecule drug to prevent muscle loss and enhance weight loss in older adults
open$1,339,717 - $1,339,717
Mitigating Physical Function Decline in Older Adults with Gastroesophageal Cancer
open$393,750 - $393,750
Lysosome homeostasis in aging-related diseases
open$51,038 - $51,038
FLASH-pulse: A versatile multiplexed tissue imaging solution for research on aging
open$397,902 - $397,902
Plasma biomarkers of cognitive decline and Alzheimer's disease and the role of social determinants of health and lifestyle factors in Nigeria
open$223,813 - $223,813
Improving Mental Health and Social Connectivity for Older Adults through Virtual Reality-Based Social Interventions
open$1,386,975 - $1,386,975
Transcriptome-wide mapping of brain m6A methylome in Alzheimer’s disease
open$848,286 - $848,286
SeeInMe: Digital Profiles Facilitating Person-centered Coordinated Care for People with Dementia
open$326,382 - $326,382
Neurotrophic Drug Development for Alzheimer's Disease
open$475,014 - $475,014
Utilization of MoTrPAC data to characterize white adipose tissue molecular aging and its potential mitigation with endurance training-from a sex-specific perspective
open$110,726 - $110,726
Prioritizing Alzheimer Disease Gene-Environment Studies Using MoTrPAC Cross-Species Tissue-Specific Exercise Response Transcriptomics
open$78,500 - $78,500
Optimizing exercise for cystic fibrosis: Understanding immune modulation and identifying blood biomarkers
open$84,166 - $84,166
Replication Analysis to Identify Acute Molecular Responses to Exercise that Lead to Chronic Training Adaptations
open$85,500 - $85,500
Disentangling Tissue and Ome Shared and Private Effects of Exercise
open$96,500 - $96,500
Scalable Technologies for the Assessment and Rescue of Brain Health: Brain-START
open$449,791 - $449,791
NIH MD/PhD Track 1 FM1 Application for Shah
open$54,538 - $54,538
Regulated RNA Splicing Response to Endurance Exercise
open$84,166 - $84,166
Estrogenic re-mapping of the metabolic response to an energy deficit
open$43,728 - $43,728
Home-based plasma self-collection device for remote diagnosis and monitoring of AD-associated biomarkers
open$305,621 - $305,621
A Type 2 Hybrid Effectiveness-Implementation Study of Time Limited Trials to Reduce Potentially Non-Beneficial Treatments for Critically Ill Patients with Advanced Medical Illnesses
open$632,507 - $632,507
Examining the association between behavioral health syndemics and menopausal symptoms in women living with and without HIV
open$43,727 - $43,727
Circadian reprogramming in cellular senescence
open$75,052 - $75,052
Mechanisms of adipose tissue functional decline with aging.
open$36,751 - $36,751
Examining Effects of Intensive BP Control on MCI/Dementia and Plasma Biomarker Trajectories by AD Pathology: Elucidating neuroprotective effects in the racially and ethnically diverse SPRINT trial
open$5,789,766 - $5,789,766
The role of depolarizing GABA in Alzheimer's disease
open$160,000 - $160,000
Peripheral nervous system aging
open$1,123,001 - $1,123,001
Improved Treatment Options for Vertebral Compression Fractures in Elderly Patients Using Minimally Invasive, Image-Guided Delivery of a Regenerative Bone Adhesive
open$2,040,626 - $2,040,626
Neuroplasticity and cerebral blood flow as key resilience mechanisms in the brains of fast-moving SuperAgers
open$1,311,772 - $1,311,772
Promoting Rigorous Biopsychosocial Lifespan Science: 82nd and 83rd Annual Meetings of the Society of Biopsychosocial Science and Medicine
open$34,526 - $34,526
The Interplay of Neuronal Activity and Synaptic Abnormalities and their Restoration through Mitochondria in Alzheimer's Disease
open$3,230,150 - $3,230,150
Dissecting the role of the PICALM/EED locus on myeloid cells in Alzheimer's disease.
open$75,520 - $75,520
CH25H mediates microglial neuroinflammation and tau toxicities in AD
open$711,898 - $711,898
Estimating the Effects of Medicare Advantage on the Health of Aging Population in Nursing Homes
open$51,038 - $51,038
Medication self-administration (MSA) and awareness of MSA: life-relevant markers of cognitive impairment
open$643,089 - $643,089
Unlocking BIN1 function in oligodendrocytes and support of axon integrity
open$2,170,748 - $2,170,748
L-Rha and L-Rha Derivatives and Their Effects on Neurodegenerative Alzheimer's Disease
open$387,549 - $387,549
Optimizing semantic memory measures of Alzheimer's disease biomarkers
open$3,030,409 - $3,030,409
Comparative and Cost-effectiveness of Personalized Targeted Multi-Factorial Approaches to Reducing Disparities in Alzheimer’s Disease and Related Dementias: The TARDIS-AD Project
open$643,139 - $643,139
Acetylation changes in alcoholic Alzheimer's disease mouse brains
open$439,865 - $439,865
The CONNECT-AD Study: Communication and Network Navigation for Effective Care Teams in Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD)
open$534,287 - $534,287
Chaplain Family Project Multicenter RCT
open$719,068 - $719,068
Dose-Dependent and Region-Specific Impacts of siRNA mediated APP Knockdown on DNA Damage and Alzheimer's Disease Pathology
open$45,294 - $45,294
Investigating the role of brain-engrafted monocyte-derived macrophages in Alzheimer's disease
open$51,038 - $51,038
Genetic dissection of microglia functions in complement-mediated synapse loss in Alzheimer s disease
open$716,579 - $716,579
Reducing Misdiagnosis in Alzheimer's Disease: AI-Driven Biomarker Identification
open$82,744 - $82,744
Integrating Multi-Omics to Uncover Shared Mechanisms Linking Physical Frailty and Alzheimer's Disease: Inflammation and Relevant Pathways
open$49,438 - $49,438
Resilience, cultural alignment, and social support in brain aging: Data from the Strong Heart Study
open$629,111 - $629,111
Endothelial TLR2/4 signaling in sex dimorphism of pathological angiogenesis and aging
open$659,309 - $659,309
The Role of APP-metabolites on Extracellular Vesicle Cargo and Function
open$639,838 - $639,838
Targeting LARP6 in aging-associated heart failure
open$429,394 - $429,394
Probing mechanistic links between endothelial aging and dementia
open$734,957 - $734,957
Understanding the mechanisms driving emergence of atypical age-associated thymic epithelial cells
open$49,538 - $49,538
A fiber implant for long-term, deep-brain imaging and manipulation in mouse models of Alzheimer disease
open$683,028 - $683,028
Development of a Plasma Biomarker for TDP-43 Proteinopathy
open$437,252 - $437,252
Dissecting the neural mechanisms of hedonic hunger and its effects on aging
open$43,109 - $43,109
Cocoa to maximize exercise training in older adults - COMET Trial
open$409,750 - $409,750
Cerebral blood flow resistance mapping to identify amyloid-related imaging abnormality (ARIA) risk in Alzheimer's disease
open$75,520 - $75,520
Exploring the Impact of Aging-Related Mechanical Changes in the Brain on Microglial Activities and Their Implications for Alzheimer's Disease Progression
open$284,108 - $284,108
Selective Vulnerability of Cholinergic Neurons in Alzheimer’s Disease
open$552,883 - $552,883
Investigating the relationship between the AD risk gene SORL1 and TDP-43 pathology in Alzheimer's Disease
open$481,277 - $481,277
Early Detection of Alzheimer's Disease using Noninvasive Retinal Fluorescence Imaging
open$659,094 - $659,094
Cell Type-Specific Epitranscriptomic Regulation in the Brain in Aging and Alzheimer's Disease
open$493,972 - $493,972
Effect of delayed microglial specific PPARγ activation on ameliorating chronic neuroinflammation and cognitive dysfunction following r-mTBI
open$468,875 - $468,875
Multiscale Models of Age-Specific Neurometabolic Coupling
open$664,619 - $664,619
Elucidation of the mechanisms by which Ms4a genes regulate neurodegeneration in Alzheimer's Disease and related disorders
open$445,130 - $445,130
Role for Semaphorin 3A in Microglial Activation and Alzheimer's Disease
open$452,375 - $452,375
Dysregulated Metabolic-Matrix Axis in MASH/HCC
open$633,393 - $633,393
Lifestyle intervention to improve muscle function in older adults
open$749,481 - $749,481
Midlife circulating autoantibodies and the risk of Alzheimer’s disease in Women
open$724,813 - $724,813
Defining the role of decreased estradiol in modulating crotonylation of myofilament proteins in aged female hearts
open$429,000 - $429,000
Network biomarkers for early detection of cognitive impairment using digital clock drawings
open$323,825 - $323,825
DISE - A universal kill code in health and disease
open$457,112 - $457,112
Microglia and Tau Oligomer Polymorphs Interplay in Cognitive Resilience in Alzheimers disease
open$564,098 - $564,098
Mechanisms of Activity-Dependent Transcription and DNA Repair in Neuronal Longevity
open$593,146 - $593,146
Uncovering the role of WFS1 deficiency in selective vulnerability in Alzheimer's disease
open$657,000 - $657,000
Multiscale Modeling of Hippocampus Vulnerability to Alzheimer's Disease Neurodegeneration.
open$695,789 - $695,789
Epigenetic mechanisms of selective vulnerability of entorhinal PV neurons in aging and AD
open$542,699 - $542,699
Astrocyte-mediated tonic inhibition in a mouse model of Lewy body dementia
open$452,375 - $452,375
CHCHD10 in Tauopathy in AD and ADRD
open$431,750 - $431,750
Environmental risk factors for early menopause among Black women
open$77,632 - $77,632
Transgenerational Adaptation of Longevity Changes in Response to Repeated Environmental Stresses
open$556,121 - $556,121
Effects of older age on the neural basis of memory generalization
open$293,454 - $293,454
Investigating the Role of Genetic Variants and Aging on Eicosanoid Metabolism in Adipose Tissue
open$446,875 - $446,875
GABAergic Circuit Targets for Modulating Entorhinal Cortex and Hippocampal Dynamics in Alzheimer's Disease
open$642,063 - $642,063
Nanoscale synaptic heterogeneity, loss, and plasticity in Alzheimer's disease
open$476,159 - $476,159
Selective vulnerability of fronto-insular network in aging and Alzheimer's disease
open$656,829 - $656,829
BOWiD: a tool for lifelong tracking C. elegans individuals using stochastically labelled landmarks
open$580,636 - $580,636
(Micro)structural Biomarkers of Skeletal Muscle Health Across the Lifespan
open$466,125 - $466,125
Mitochondrial and energetic underpinnings of resilience in human aging: integrating genetic and epidemiological evidence
open$690,865 - $690,865
The brain as a control center for other organs during aging
open$1,468,868 - $1,468,868
Novel in situ analysis of the functional impacts of osteoarthritis in the mouse model
open$560,380 - $560,380
Tissue-Specific Modulation of mtDNA Mutations: Exploring Aging and Lifestyle Interventions
open$567,224 - $567,224
Understanding linguistic differences in mild cognitive impairment: The importance of language context and psychosocial functioning
open$46,086 - $46,086
Epigenetic Aging: The Impact of Social and Environmental Realism
open$458,871 - $458,871
Understanding sphingolipid-dependent remodeling of mitochondria in aging cells
open$482,800 - $482,800
Molecular Mechanisms of Fiber Type-Specific Skeletal Muscle Dysfunction with Aging
open$698,690 - $698,690
Aging Impairs Wound Healing by an HSC-Autonomous Mechanism
open$626,409 - $626,409
miRNA-Driven Mitochondrial Dysfunction in Alzheimer’s Disease
open$447,541 - $447,541
Developing robust zero-shot AI models for anti-aging antibody design
open$615,390 - $615,390
Next Generation Treatment of PAD
open$644,298 - $644,298
Technologies to probe the biophysical properties of aging cells
open$708,137 - $708,137
CSHL 2026 Protein Homeostasis in Health & Disease Conference
open$33,900 - $33,900
Investigating the role of the gut-brain axis in Alzheimer's Disease mitigation: 7T MRI, iNOS inhibition and inulin diet
open$676,608 - $676,608
Elucidating the interplay between AD genetic variants using human iPSC-derived brain cells
open$470,000 - $470,000
MR imaging of venous transit time in vascular cognitive impairment and dementia
open$465,035 - $465,035
Adaptation and Validation of Tablet-based Cognitive Assessments for Diverse Populations in Cameroon
open$215,995 - $215,995
Synergistic Effects of Unacylated Ghrelin and Endurance Exercise on Sarcopenia and Mobility Loss
open$599,623 - $599,623
Novel pro-drug imaging agents to detect neuroinflammation in Alzheimer's Disease
open$758,781 - $758,781
Impact of Cellular Senescence on the Development of Pelvic Organ Prolapse
open$718,505 - $718,505
Role of OXR1 and the retromer in brain aging and Alzheimer's disease and related dementias
open$809,486 - $809,486
The role of HSPGs in tau uptake in cell and mouse models
open$456,500 - $456,500
Vibegron: A Novel Treatment for Multisystem Functional Decline in Aging and Obesity
open$426,250 - $426,250
Sympathetic Consequences of the Menopausal Transition
open$651,816 - $651,816
Smooth muscle O-GlcNAcylation and vascular aging in metabolic syndrome
open$611,680 - $611,680
Novel Machine Learning Methods for Immunosenescence and Aging Research
open$298,419 - $298,419
Longitudinal relationships between Alzheimer's disease pathophysiology, local sleep expression, and sleep-dependent memory across preclinical stages
open$619,099 - $619,099
Decoding antigen specific T cells in frontotemporal degeneration
open$425,235 - $425,235
Normalized cerebrovascular reactivity MRI in small-vessel-disease (SVD) related cognitive impairment
open$589,154 - $589,154
Contribution of intramural von Willebrand factor (VWF) to cerebrovascular dysfunction in amyloidosis
open$650,533 - $650,533
Mechanisms of Activity-Dependent Tau Release: The Role of Tau Interacting Proteins
open$567,256 - $567,256
Arginine Sensor (CASTOR1) Dysfunction Drives Tauopathy
open$423,500 - $423,500
Metal Exposures, Omics, and AD/ADRD risk in Diverse US Adults
open$10,223,348 - $10,223,348
Exploring the links between cyclin D1, metabolism and aging
open$423,500 - $423,500
Unlocking bat biology to extend ovarian health and reproductive longevity in women
open$433,125 - $433,125
Women’s Health and Aging: Developmental Pathways Underlying Life Course Risk
open$651,175 - $651,175
Decoding the Muscle Epitranscriptome: Deep Learning Detection of RNA Modifications in Aging Muscle
open$616,000 - $616,000
Reproductive events, menopause and biological aging among Latina women
open$391,250 - $391,250
The Legacy of Childhood SES and Lead Exposure on Dementia Risk: ARIC-NCS Historical Census Linkage
open$645,743 - $645,743
CRISPR for tauopathy
open$680,792 - $680,792
Defining the Role of Hsa21 Gene Overexpression in Aging-Associated and Aβ-Induced Neurodegeneration in C. elegans
open$429,000 - $429,000
Addressing population and platform heterogeneity in epigenetic clocks via transfer learning and conformal prediction methods
open$461,514 - $461,514
Ciliopathy Features in Mouse Models of Down Syndrome
open$429,262 - $429,262
Role of Brd4 in enhancing old donor heart preservation quality via 3D chromosomal restructuring
open$660,157 - $660,157
Pilot of a new non-viral vector for therapeutic nucleic acid delivery to the CNS
open$466,340 - $466,340
Functional characterization of adipocyte-derived lipocalin 2-containing extracellular vesicles in senescence
open$423,500 - $423,500
Endothelial Enhancer of Zeste Homolog 2 in Cerebral Amyloid Angiopathy and Alzheimer's disease
open$654,110 - $654,110
Mechanisms of Fatigability and the Protective Effects of Exercise in People with Diabetes
open$950,749 - $950,749
A Deep Learning-based Miniature Microscope for Imaging Aging and Alzheimer's Disease Brains
open$618,410 - $618,410
Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)
open$578,469 - $578,469
Patient Outcomes and Health Care Use in U.S. Hospices After Private Equity Acquisition
open$683,924 - $683,924
Age Differences in the Acquisition and Retention of Flexible Navigation Behaviors
open$427,625 - $427,625
Personalized Memory Enhancement in Aging: Pattern-Optimized tACS with Closed-Loop Precision Modulation
open$343,350 - $343,350
Suppressing aging-associated increase of GATA4 levels to rejuvenate old chondrocytes
open$428,123 - $428,123
Improving advance care planning by persons living with dementia using narrative video games
open$453,932 - $453,932
Molecular signatures and markers of erythropoietin competence in the kidney
open$481,250 - $481,250
AI Driven Drug Discovery Pipeline for Lead Optimization: from Virtual Screening to Preclinical Validation of Brain-Penetrant AD Therapeutics
open$1,232,416 - $1,232,416
Aging: Immune Function and Organ Health
open$19,600 - $19,600
The Profibrotic Effects of Hematopoietic Y Chromosome Loss in HFpEF
open$689,148 - $689,148
Improving Hormone Therapy Use in Patients with Premature or Early Menopause
open$552,154 - $552,154
Mitochondria and synapse crosstalk in AD circuit vulnerability
open$322,000 - $322,000
CoMTAD: Cognitive Monitoring during Treatment for Alzheimer disease
open$589,614 - $589,614
Evaluation of Noninvasive Muscle Imaging Biomarkers for Knee Osteoarthritis in Older Adults
open$666,504 - $666,504
Clinical, Anatomic, and Pathologic Spread of Semantic Language Impairment in the Type C Variant of Frontotemporal Lobar Degeneration due to TDP-43 (TDP-C)
open$49,538 - $49,538
Cytomegalovirus, midlife inflammation, and subclinical cardiovascular disease: the Study of Women's Health Across the Nation
open$127,710 - $127,710
A prospective study of viral infections and subsequent risk of Alzheimer’s disease
open$712,578 - $712,578
p66Shc in Cerebrovascular Impairment in Alzheimer’s Disease
open$441,460 - $441,460
Lympnoids tissue senescence and multimodal imaging using REDCAT
open$700,795 - $700,795
INFUSE HFPEF
open$680,818 - $680,818
Assessing the longitudinal impact of Mediterranean diet interventions to reduce cognitive decline on gut microbiota composition and bile acid variety
open$43,784 - $43,784
Development and assessment of new highly specific PET tracers for imaging innate immune activation in Alzheimer's disease
open$50,114 - $50,114
Understanding dynamics and phenotypic consequences of clonal hematopoiesis caused by mosaic chromosomal alterations
open$35,593 - $35,593
ROOTS: Revealing cognitive Outcomes in 'zeroth gen' Older immigranTS
open$453,750 - $453,750
Activity-dependent cell survival in the adult somatosensory dorsal horn: Implications for sensorimotor behaviors during aging
open$620,441 - $620,441
RETURN: RECOVERY TO PHYSICALFUNCTION AFTER CRITICAL ILLNESS IN OLDER ADULTS
open$382,830 - $382,830
Non-medical Supplemental Benefits, Health Service Utilization, and Health Outcomes in Medicare Advantage.
open$591,089 - $591,089
Defining Pathological Roles of Novel Protein Interactions with Amyloid in Alzheimer's Disease
open$657,222 - $657,222
Temperature-Related Mortality in U.S. State Prisons
open$560,180 - $560,180
The Coma Family Program (COMA-F): A multi-site clinical trial of a resilience program for caregivers of patients with severe acute brain injury
open$722,746 - $722,746
Genetic dissection of the 17q21.31 MAPT locus in neurodegenerative disease
open$790,288 - $790,288
Effects of Wildfire Exposure on Markers of Accelerated Brain Aging and Dementia Risk
open$701,073 - $701,073
Estrogen exposure across the lifetime protects against Alzheimer's disease: Contributions of hormone contraceptives
open$424,371 - $424,371
Alzheimer Disease Genetic Analysis to Identify Potential Therapeutic Targets (ADAPTT)
open$1,256,627 - $1,256,627
Human Neurogenesis: Unraveling Controversies and Charting New Frontiers
open$49,620 - $49,620
Cognition Aging and Speech Communication Conference
open$53,461 - $53,461
Cell therapy for Alzheimer's disease
open$3,174,899 - $3,174,899
GLP-1 Agonists for Preventing Alzheimer's Disease in Mild Cognitive Impairment
open$324,000 - $324,000
The role of conjunctive representations in cognitive control, learning, and aging
open$303,163 - $303,163
Enhancing Palliative Care Integration in Home Healthcare: Assessing Readiness, Identifying Needs, and Overcoming Challenges (EPIC-HHC)
open$713,283 - $713,283
Regulatory Landscape of Neurodegeneration by Single-Cell Spatial Multiomics
open$454,937 - $454,937
Generative Peptide Drug Design for AD/ADRD
open$1,293,752 - $1,293,752
Unraveling a Vicious Cycle: Entorhinal Cortex Hyperactivity, Neuroinflammation, and the Progression of Tauopathy
open$529,744 - $529,744
CS6253 Sequential Subcutaneous Pharmacokinetic Study followed by Phase 2A Placebo-Controlled Trial with Three Fixed Doses in APOE4 MCI and AD Patients to assess Safety, PK, and Biomarker Effects
open$2,644,490 - $2,644,490
The Role of PML in Oxidative Stress and Alzheimer's Disease
open$651,466 - $651,466
A Novel Astrocyte Endfoot Protein Arising from Translational Readthrough and Influencing Alzheimer's Disease Pathology
open$347,657 - $347,657
Control of CSF hydrodynamics and brain-waste clearance
open$573,035 - $573,035
Interaction between Systemic Endothelial Glycocalyx Fragility and Brain Dysfunction in Aged Sepsis Survivors
open$634,658 - $634,658
Longitudinal Impact of Clonal Hematopoiesis on Aging Outcomes and Risk Prediction in the REasons for Geographic and Racial Differences in Stroke Study
open$664,971 - $664,971
Assessing the role of lncRNA SLAMR in the pathogenesis of Alzheimers disease
open$507,214 - $507,214
Mechanisms of Dysregulated Translation in Human Neurons Carrying FTD-associated Tau Mutations
open$422,297 - $422,297
Deciphering the metabolism and protective role of the essential nutrient, DHA
open$668,290 - $668,290
EEG-guided analgesic titration during general anesthesia to improve early neurocognitive recovery in older patients
open$577,122 - $577,122
The risk of Alzheimer's disease and related dementias among individuals with Autism Spectrum Disorder (AsDRD)
open$625,347 - $625,347
Testing Cognitive Behavioral Therapy for Insomnia (CBT-I) on Dyadic Sleep in Dementia: A Randomized Control Trial
open$627,646 - $627,646
Cognitive-Motor Processes of Volitional Stepping
open$603,165 - $603,165
RANDOMIZED CLINICAL TRIAL OF SUPPLEMENTING GLYNAC IN TYPICAL OLDER ADULTS TO PROMOTE HEALTHY AGING
open$655,417 - $655,417
Understanding ApoE4-induced metabolic shifts in Alzheimer's disease
open$801,193 - $801,193
Pharmacoepidemiologic Study of Proton Pump Inhibitors and Alzheimer's Disease Risk
open$431,750 - $431,750
Implementation of Aging-in-Place Services for Older Adults with Alzheimer's Dementia
open$670,904 - $670,904
Integration of artificial intelligence and drug discovery to treat Alzheimer’s disease
open$1,250,191 - $1,250,191
Mechanisms of protective UFM1-dependent IRE1 signaling in tauopathies
open$681,908 - $681,908
Improving Residual Sleepiness and Inflammation in Older Adults with OSA: An RCT of Citicoline
open$494,109 - $494,109
Patch for hemodynamic and hemorrhage monitoring
open$408,504 - $408,504
Sleep reinforces homeostatic set-points in neural activity and mitigates neurodegenerative disease
open$578,856 - $578,856
Deciphering Proteomic Aging: From Causal Mechanisms to Frailty Prediction.
open$134,726 - $134,726
A Human iPSC-derived Microphysiological 3D model to study CAA/AD
open$428,175 - $428,175
Targeting Intramuscular Adipose Quality in Aging
open$427,625 - $427,625
PET imaging of alpha-synuclein pathology
open$677,276 - $677,276
MR1/MAIT cell axis-mediated regulation of inflammatory responses
open$624,837 - $624,837
Clinical Spectrum and Societal Impact of Cognitive Impairment, Alzheimer's and Related Dementias among people with HIV in Uganda
open$738,105 - $738,105
Understanding the Role of Nursing Home Enforcement and Oversight in Post-Acute and Long-Stay Resident Quality of Care
open$676,587 - $676,587
Enhancing the Pathology, Alzheimer’s and Related Dementias Study to Understand Ancestry, Pollution Exposure, and AD/ADRD(PARDoS APEX)
open$2,586,176 - $2,586,176
Epigenetically optimized replication-defective Herpes Simplex Virus vectors for multigenic gene therapy in Alzheimer’s disease.
open$433,710 - $433,710
Mapping cerebellar influence in FTD: unraveling the role of the cerebellum in social cognition and clinical trajectory
open$119,785 - $119,785
AI-driven discovery of in vivo chemical probes for understudied targets for the treatment of Alzheimer's disease and related disorders (ADRD)
open$1,074,362 - $1,074,362
Using DNA-Encoded Chemical Libraries to Enable Machine Learning for Alzheimer's Disease Drug Discovery
open$1,343,997 - $1,343,997
Metabolomic correlates of improved Alzheimer’s disease polygenic risk score for diverse populations
open$41,757 - $41,757
Neuromelanin Formation and Toxicity in the Locus Coeruleus: The Role of Norepinephrine Metabolism
open$50,114 - $50,114
CRCNS: The noradrenergic modulation during sleep: from circuits to memory
open$182,173 - $182,173
Untangling the effects of anti-amyloid therapy on neurodegeneration and neuroinflammation
open$196,020 - $196,020
PG4AD: Scaling up pangenome graph for genotyping complex structural variations for Alzheimer's disease genetics
open$556,359 - $556,359
Subjective cognitive decline as a risk for Alzheimer's disease and vascular cognitive impairment across diverse groups
open$690,934 - $690,934
Identifying and characterizing new therapy targets in TDP-43 proteinopathies
open$162,000 - $162,000
HCN Channels Mediate Olfactory Dysfunction in Aging and Neurological Disease
open$649,766 - $649,766
Imaging Soluble Amyloid Oligomer Flow Dynamics in the Eyes for Detection of Alzheimer's Disease
open$659,026 - $659,026
Advancing the Science of Social Connection Across the Life-Course: The Next Generation of Measurement in the United States
open$50,000 - $50,000
Dissecting the molecular mechanism of ketogenic metabolites in AD
open$47,863 - $47,863
CONGAS: "Caribbean Omics 'N' Genomics for Alzheimer Study"
open$3,086,339 - $3,086,339
Non-invasive Modulation of Microglia Gene Expression Using Peripherally Administered Antibody Conjugates
open$655,198 - $655,198
Integrative Analysis to Understand the Contribution of the X Chromosome to Alzheimer's Disease
open$3,232,914 - $3,232,914
VOCALE: A Digital Intervention to Improve Quality of Life and Reduce Frailty Among Older Adults in CCRCs - A Randomized Controlled Trial
open$505,948 - $505,948
Multi-biomarker evaluation of 64Cu-FBP8 PET for imaging of brain fibrin in aging and neurodegeneration
open$684,567 - $684,567
Tackling Disparity with Sound: Audio-Recorded Patient-Clinician Communication for Early Detection of Mild Cognitive Impairment in Black Older Adults
open$3,406,699 - $3,406,699
Sleep and Circadian Rhythm Biomarkers of Postoperative Neurocognitive Recovery (SLEEP-POD2)
open$868,901 - $868,901
Synaptic and behavioral changes induced by hearing loss and Alzheimer's disease in the auditory brainstem.
open$657,439 - $657,439
Short-term practice effects in Subjective Cognitive Decline: Moderators, prognostic value, and relationship to biomarker status
open$607,706 - $607,706
Effect of paid family care (vs aides) on Medicaid waiver participants w/ IDD across the lifespan
open$678,231 - $678,231
Major pharmacy chain and retailer investments in primary care and implications for access to and quality of care in older adults
open$129,096 - $129,096
Investigating the Mechanisms of Hair Progenitor Cell Activation and Aging Resistance Through SOX5
open$55,114 - $55,114
The Role of microRNA-1 in Regulating Pyruvate Metabolism in Patients with Peripheral Artery Disease
open$166,152 - $166,152
Leveraging the Trusted Role of Churches to Disseminate Research, Resources, and Support to Communities Disproportionately Affected by Dementia
open$50,000 - $50,000
Estrogen Signaling in Urinary Tract Infection Related Delirium
open$717,957 - $717,957
Identification of the impact of Focused Ultrasound Induced Blood-Brain Barrier Opening (FUS-BBBO) on brain-wide memory traces in Alzheimer's disease
open$458,622 - $458,622
Promoting Exercise to Mitigate Hospital-Associated Disability for People with Dementia - A Feasibility Pilot
open$209,690 - $209,690
Utilizing Heterogeneous Mouse Models to Discover Mechanisms Underlying Caloric Restriction (CR) on Cognitive Outcomes
open$1,732,842 - $1,732,842
Loneliness and inflammatory markers as biopsychosocial pathways to AD/ADRD: Analysis of a rapidly aging segment of the US population
open$121,239 - $121,239
Training Leaders to Improve Outcomes in Older Adults Using Advanced Methods
open$214,223 - $214,223
Investigating Thalamocortical Spike Dynamics to Increase Sleep Stability and Memory in Alzheimer’s Disease
open$296,232 - $296,232
Modifiers of Tau Seeds in Human Brain
open$691,999 - $691,999
The utility of cyclooxygenase-1 PET imaging as a novel neuroinflammatory biomarker for Alzheimer's disease
open$921,020 - $921,020
Deep templates for longitudinal morphometry in Alzheimer's disease
open$660,000 - $660,000
The Proteomic Signature of Sleep and its implication for Alzheimer's Disease
open$691,009 - $691,009
Defining short RNAs that antagonize deleterious phase transitions of TAF15 in ADRDs.
open$446,875 - $446,875
Mosaic loss of the Y chromosome in transthyretin (ATTR) cardiac amyloidosis
open$763,561 - $763,561
Discovery of disease-associated eQTLs with a scalable human in vitro model of microglia-astrocyte interactions
open$354,000 - $354,000
Novel Group ICA Incorporating Time-Frequency Information for Longitudinal Brain Network Analysis
open$390,122 - $390,122
Longitudinal MRI Measures of Cerebrovascular Injury and AD Atrophy in a Study of Latinos (SOL-INCA-MRI Long)
open$3,517,625 - $3,517,625
Dissecting Inflammatory and Immune Mechanisms Driving Ovarian Tissue Aging
open$711,479 - $711,479
Design & Development of Brain Game Center Infrastructure
open$159,490 - $159,490
Real world impact of glucagon-like peptide receptor agonist (GLP-1 RA) use on older adults
open$443,850 - $443,850
Molecular Determinants of Age-Related Cognitive Decline in the Basal Forebrain to Lateral Entorhinal Cortex Circuit
open$198,352 - $198,352
GAPcareAD: A Brief Emergency Department Intervention to Address Post-Fall Care Needs of Persons Living with Dementia and Care Partners
open$783,984 - $783,984
Occupational Determinants of Cognitive and Brain Health Among Middle-Aged and Older Latinos in the U.S.
open$123,876 - $123,876
The Role of β-Catenin in Lung ILC-2 Functions
open$461,138 - $461,138
Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat2)
open$1,307,141 - $1,307,141
Life-spanning study of Polycomb regulation by cohesin
open$51,038 - $51,038
Impact of peripheral inflammation on microglia and neurons in aging
open$746,160 - $746,160
Combining Brain Stimulation with Computerized Cognitive Training for MCI
open$210,168 - $210,168
Dissecting the role of Tau-induced changes of SUMO and succinylCoA conjugation in mitochondrial-nuclear anterograde and retrograde signaling in FTD
open$472,073 - $472,073
The Effect of Serum Psychotropic Drug Levels and Drug Metabolizer Status on Delirium Duration and Long-term Cognition
open$1,574,743 - $1,574,743
Computational phenotyping of cancer-related cognitive impairment in older adults
open$111,715 - $111,715
Targeted lipid-siRNA complexes for SPP1-silencing in Alzheimer's Disease
open$35,017 - $35,017
Olfactory dysfunction as predictor of PM2.5 exposure progression to dementia
open$3,264,260 - $3,264,260
Investigating the Benefits of Remotely-supervised Neuromodulation in Primary Progressive Aphasia
open$5,343,452 - $5,343,452
American Academy of Hospice and Palliative Medicine State of the Science in Hospice and Palliative Care Research Symposium
open$50,000 - $50,000
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Grants802
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