Funding Organization

National Institute of General Medical Sciences

952 opportunities

About

No description available for this funder.

Grants (952)

Regulation of Cryptosporidium Development

open
$251,625 - $251,625

G-RISE at University of Nevada, Las Vegas

open
$264,561 - $264,561

Pacific Center for Artificial Intelligence and Data Science in Medicine (PAC-AID)

open
$2,647,500 - $2,647,500

CWRU Postbaccalaureate Research Education Program

open
$502,792 - $502,792

Enhancing Faculty Mentorship of PhD Students in Biomedical Research

open
$342,000 - $342,000

A Fully Integrated Platform for Reproducible and Scalable Single-Cell Sequencing in Clinical Research

open
$382,798 - $382,798

Pain State Modulation of Emergence from Anesthesia

open
$79,300 - $79,300

Center for Aging with Serious Illness (CASI)

open
$2,379,060 - $2,379,060

Deacetylated Sialic Acid Inhibit NK Cell Killing Function via Siglec-7/9-Mediated Suppression of NKG2D-DAP10 Signaling

open
$273,651 - $273,651

Rewiring nucleosome engagement through chemically induced proximity

open
$79,348 - $79,348

Live-cell functions of histone PTM readers and histone H2A.Z variant in epigenetic regulation of transcription

open
$326,463 - $326,463

Understanding how environmental microbiomes shape animal sensation

open
$125,000 - $125,000

AI-enabled methods for de novo design of functional peptides

open
$517,083 - $517,083

Facilitating the Advancement of Research and Education for Undergraduate Students by Incorporating Laser Scanning Confocal Microscopy (FAREUS-LSCM)

open
$250,000 - $250,000

Cytoskeletal connectors: Deciphering the fundamental mechanisms of cytoskeletal dynamics and transport

open
$515,625 - $515,625

The diverse roles of ER-Golgi trafficking machinery in autophagy and ER quality control

open
$11,651 - $11,651

Mechanistic studies, divergent chemoselectivity, and electrophilic additions for Birch-type reductions

open
$371,175 - $371,175

Ubiquitin-mediated regulation of repair pathway choice at persistent double-strand breaks in yeast

open
$342,570 - $342,570

Selective autophagy mediated by TRIM proteins

open
$517,014 - $517,014

Engineering Specialized Organelles in Yeast for Compartmentalized Production of Therapeutics

open
$387,596 - $387,596

The roles of the epitranscriptome in tailoring gene expression systems

open
$390,966 - $390,966

Mechanism, Structure, and Inhibition of N-Monooxygenases

open
$528,560 - $528,560

Liquid-Chromatography Tandem Mass Spectrometry (LC-MS/MS) System

open
$250,000 - $250,000

Developing next-generation mass spectrometric platforms for molecular cartography of the cellular membranes

open
$304,970 - $304,970

Deeply subwavelength near infrared imaging with avalanching nanoparticles

open
$430,109 - $430,109

Mechanisms of Mpro autocleavage

open
$583,503 - $583,503

Mechanisms of Lysosomal Resilience, Repair and Removal

open
$425,916 - $425,916

Imaging Single Photocatalytic Turnovers in Photoredox Catalysis for Efficient DrugSynthesis

open
$554,078 - $554,078

Decoding the sequence basis of genome regulation

open
$357,809 - $357,809

A novel role for cohesin-STAG2 in R loop homeostasis

open
$534,644 - $534,644

Computational Modeling of RNA Polymerase II Elongation Complex Dynamics

open
$400,910 - $400,910

Mechanism-Based Design of Iron-Mediated Carbonyl-Olefin Metathesis Protocols

open
$484,636 - $484,636

Generative AI-Powered Exploration of Protein Dynamics and Non-Deterministic Chemical Kinetics

open
$447,174 - $447,174

Identifying and modulating mechanistic cellular paths of quiescence deepening and transition to senescence

open
$1,386,390 - $1,386,390

Mechanistic Investigations into Hydropersulfide (RSSH) Donor-Mediated Rescue of Deficient Iron-Sulfur Cluster Biosynthesis in Friedreich's Ataxia Fibroblasts

open
$325,665 - $325,665

Uncovering novel cholesterol-protein interactions in cholesterol-producing and cholesterol-utilizing bacteria

open
$440,750 - $440,750

TERPENE: Titer Enhancement via Refactored Precursor pathways for Natural Produce Discovery

open
$423,500 - $423,500

Coupling of protein synthesis with cell division

open
$423,500 - $423,500

Harnessing Biomolecular Simulations to Understand Protein Dynamics and Allostery

open
$432,850 - $432,850

Mechanisms of Gut-Brain Communication Underlying Behavioral State Transitions

open
$435,829 - $435,829

Understanding the Mechanisms of Muscle Catabolism after Burn Injury

open
$107,307 - $107,307

Investigating the Role of Proton-Sensing G Protein Coupled Receptors in Trauma and Hemorrhagic Shock

open
$200,613 - $200,613

Defining the role of PRR12 in cohesin-mediated DNA damage repair and genome stability

open
$76,300 - $76,300

Uncovering the structure and function of understudied membrane proteins

open
$375,154 - $375,154

Next-Generation Native Ion Mobility-Mass Spectrometry Methods for the Characterization of Biotherapeutics

open
$565,993 - $565,993

Untangling the Inner Workings of the Mycobacterial Cell Envelope

open
$432,892 - $432,892

Genetic and neural circuit mechanisms responsible for the acute to chronic pain transition

open
$454,300 - $454,300

Interplay of conformational and redox properties of cytochromes in disease

open
$408,750 - $408,750

Optogenetics and biosensors for dissecting cellular decision-making

open
$369,000 - $369,000

Molecular regulation of endothelial glycocalyx-mediated transcytosis

open
$374,550 - $374,550

Genome Organization and Function in Fungi

open
$325,938 - $325,938

Exploring conformational and chemical spaces with advanced molecular simulation algorithms

open
$593,975 - $593,975

Spatiotemporal regulation of DNA metabolism pathways

open
$433,125 - $433,125

UNDERSTUDIED NICHE PLAYERS GOVERNING TISSUE-SPECIFIC PROGENITORS

open
$435,875 - $435,875

Determining the interactome and function of the neurabins across cell and tissue types.

open
$332,403 - $332,403

Control of transcriptional integrity by Integrator and PP2A

open
$591,549 - $591,549

Expanding structural proteomics to monitor proline isomerization

open
$1,368,400 - $1,368,400

Systematic characterization of human disease associated protein complexes

open
$380,350 - $380,350

Electric-Field Stimulated Protein Dynamics

open
$2,506,748 - $2,506,748

Initiative for Maximizing Student Development (IMSD) (T32) at Rutgers University-Newark

open
$581,440 - $581,440

Integrative physiology of the organismal osmotic stress response

open
$501,385 - $501,385

Allosteric Mechanisms and Regulation of Drp1-catalyzed Mitochondrial Fission

open
$461,355 - $461,355

Apical extracellular matrix regulates tracheal tube development

open
$573,750 - $573,750

Securing and advancing natural products from remote ecosystems to inspire biomedical innovations

open
$474,102 - $474,102

Genomic Enzymology to Decipher Bacterial Membrane-Associated Glycan Assembly

open
$437,036 - $437,036

Mechanisms of Processive Antitermination in Gram-Positive Bacteria

open
$381,240 - $381,240

Establishing Glyoxalase 2 as a Viable Target for the Treatment of Disease

open
$407,323 - $407,323

Characterizing glycosylation regulatory networks using single-cell multiomics and mathematical modeling

open
$343,007 - $343,007

Modeling the Cascade of Genome Rearrangements in the ciliate Oxytricha trifallax

open
$76,300 - $76,300

Rapid, high throughput acquisition of 3D morphology of single cells

open
$493,884 - $493,884

The role of RNA editing in organizing the cytoplasm.

open
$125,000 - $125,000

New Cobalt-mediated Methods for the Synthesis of Bioactive Triterpenoid Natural Products

open
$580,064 - $580,064

Regulation of apical constriction by the RhoGEF protein Plekhg5

open
$445,358 - $445,358

Multiplexed Optical Sensors for Redox Profiling in Human iPSC Models of Disease and Drug Response

open
$472,629 - $472,629

Understanding Metabolic Reprogramming in Reparative Macrophages

open
$433,125 - $433,125

Development of a synthetic biology tool to engineer proteins with multiple modifications and elucidate their binding function

open
$2,014,434 - $2,014,434

Cellular basis of complex behavior

open
$407,283 - $407,283

Development of technologies for elucidating the function of cryptic intergenic regions within genomes

open
$1,920,000 - $1,920,000

Development of a Three-Component Iron-Catalyzed Difluoromethylation Reaction

open
$75,880 - $75,880

Biophysical investigation of bacterial lipid trafficking proteins for novel antibiotic development

open
$515,862 - $515,862

Molecular systems that modulate nucleic acid repeat instabilities

open
$246,999 - $246,999

Cell membrane response to electrical stress at nanosecond and nanometer resolution

open
$320,000 - $320,000

Decoding the temperature and moisture sensory mechanisms in insects

open
$432,357 - $432,357

Development of High-Speed Atomic Force Microscope-Infrared Microscopy in the Aqueous Phase

open
$1,367,189 - $1,367,189

Understanding Mammalian Golgi Trafficking Mechanisms

open
$605,140 - $605,140

The role of UFMylation in ribosome quality control

open
$285,031 - $285,031

Dysbiosis, organ injury, and Systemic Inflammation

open
$440,908 - $440,908

Structural and Molecular Basis of Polq Functions in DNA repair

open
$506,018 - $506,018

Mechanosensitive mechanisms regulating cellular coordination during tissue morphogenesis and patterning

open
$483,175 - $483,175

Development of ClusterBuild to Synthesize Biosynthetic Gene Clusters

open
$306,151 - $306,151

Structural Insights into Calcium Signaling at ER-Mitochondria Contact Sites

open
$435,875 - $435,875

Medical Artificial Intelligence Core (MEDAI Core)

open
$626,000 - $626,000

Innovative Approaches to Trauma Care

open
$103,795 - $103,795

Structure Elucidation and Rational Drug Discovery of a Bacterial Membrane Protein that Confers Polymyxin Resistance

open
$46,528 - $46,528

Multidisciplinary Anesthesiology and Perioperative Medicine Research Training Program

open
$3,000 - $3,000

Multi-Omics Technology and Development Core

open
$148,270 - $148,270

Quantitative membrane contact site biology in autophagy

open
$404,864 - $404,864

Regulation of single cell migration in vivo

open
$392,942 - $392,942

Navajo NARCH Partnership

open
$906,887 - $906,887

Mechanisms of misfolded protein sequestration and degradation

open
$569,258 - $569,258

Revealing the cullin-RING ligase code

open
$411,739 - $411,739

Regulation of CK1 substrate specificity during DNA repair

open
$481,808 - $481,808

Unraveling the Complexity of RNA Polymerase I Biogenesis and Transcription Regulation.

open
$448,250 - $448,250

Nanodiamond quantum sensing in redox cell biology by hyperspectral microscopy

open
$527,392 - $527,392

Causes and consequences of genome instability and chromosome rearrangements

open
$435,405 - $435,405

The Architecture of Species Interactions

open
$467,500 - $467,500

Systems-Level Principles and Mechanisms Underlying Cellular Adaptation

open
$444,907 - $444,907

DNA damage tolerance strategies at the organismal level

open
$391,999 - $391,999

Decoding and engineering free energy landscapes for mechanistic insight and functional protein design

open
$125,000 - $125,000

Mechanisms of adaptive immunity in RNA-targeting CRISPR-Cas13 systems

open
$487,500 - $487,500

Development of an Ultra-Broadband Microscope

open
$1,835,222 - $1,835,222

Evolution and population genetics in microbial populations

open
$463,375 - $463,375

Illuminating jumbo phage infection mechanisms: from complex prokaryotic cell biology to novel therapeutics

open
$123,147 - $123,147

Establishment and Modulation of DNA Methylation Patterns During Plant Development

open
$515,625 - $515,625

Molecular mechanisms of myosin-X and filopodial function

open
$432,135 - $432,135

Inter-organ crosstalk and the regulation of lipid metabolism

open
$533,171 - $533,171

The Chickasaw Nation's Tribal Institutional Review Board Establishment and Enhancement (TIRBEE) Application

open
$430,408 - $430,408

Decoding the Sulfation Code: Selectively Sulfated Glycomacromolecules as Tools to Investigate Viral Protein-Carbohydrate Recognition

open
$487,727 - $487,727

Neuroimaging-guided Immunotherapy for Glioblastoma

open
$210,086 - $210,086

Nutrition and Metabolic Health Center (NMHC) COBRE

open
$2,652,150 - $2,652,150

Non-Canonical Functions of Polycomb Complexes in Health and Disease

open
$318,084 - $318,084

Healthy Idaho Clinical and Translational Research Development Program Professional Development Core

open
$145,493 - $145,493

Puerto Rico Center for Microbiome Sciences

open
$2,447,771 - $2,447,771

NARCH XIII-Student Development Program

open
$329,792 - $329,792

Center for Implementation Science: Implementation Research Core

open
$534,843 - $534,843

Pharmacology Core

open
$464,538 - $464,538

Revealing and Live Imaging the LINE-1-RNA Intractome

open
$220,784 - $220,784

Blackfeet Community College Center for Community Medicine

open
$891,571 - $891,571

Linking Daily Parental PACEs to Parenting and Preschoolers' Self-Regulation Growth: A Burst-Design Longitudinal Study

open
$229,325 - $229,325

Unraveling the Activation Mechanism and Therapeutic Potential of PEDF-R

open
$243,048 - $243,048

Stress-Induced Aberrations in the Mitochondrial Redox Environment Impact Developing Neural Circuits Supporting Cognitive Control

open
$391,933 - $391,933

Structure-guided design of durable pan-lyssavirus vaccines and anti-viral antibody therapies

open
$213,562 - $213,562

Deciphering piRNA-based immunity in germ cells across space and time

open
$444,788 - $444,788

Data-driven modeling of estrogen receptor

open
$431,750 - $431,750

Identification and Characterization of a Novel Copper-Sensing Receptor in C. elegans

open
$257,400 - $257,400

Integrated nanophotonic imaging and spectroscopy technology for scalable, purification-free, multi-parametric single exosome analysis

open
$431,750 - $431,750

Multiscale Computational Models of Heterochromatin Phase Separation

open
$135,000 - $135,000

Mechanisms governing the midbody remnant in intercellular RNA communication

open
$580,507 - $580,507

A generalizable computational platform for early organ vulnerability modeling and therapeutic discovery using systemic omics and imaging

open
$437,250 - $437,250

Healthy Idaho Clinical & Translational Research Development Program

open
$2,185,745 - $2,185,745

Multimorbidity Subphenotypes and Effects on Post-Intensive Care Physical Impairments

open
$275,460 - $275,460

Stereoselective Photoenzymatic O- and N-centered Radical Transformations Mediated by the Pyridoxal 5’-phosphate Cofactor

open
$76,300 - $76,300

Development of a Farnesol-Based Liposome Delivery System for Neuroprotection

open
$146,673 - $146,673

Actin cytoskeleton organization and function in health and disease

open
$441,570 - $441,570

High Quality Force Field Models for Biased Ligand Design

open
$108,500 - $108,500

Next Generation Visualization and Analysis Software for Multiscale Modeling

open
$562,484 - $562,484

Multi-scale and multi-modal computational modeling of cell state plasticity and drug response

open
$390,000 - $390,000

Mapping The Molecular Architecture Of Biomolecular Condensates With Crosslinking Mass Spectrometry

open
$414,709 - $414,709

Unveiling Hidden Cellular Architecture: Mapping the intracellular Protein Organization Landscape (iPOL) to define cell states and types

open
$370,550 - $370,550

Exploring the Mechanisms and Cellular Specificities of Antifungal Toxins

open
$426,404 - $426,404

Resolving multi-site protein phosphorylation by phosphoryl-AMPylation

open
$449,900 - $449,900

Deciphering Signaling Network Dynamics, Structure, and Function

open
$458,950 - $458,950

Unraveling the Molecular Mechanisms of the MRAS-SHOC2-PP1C Complex

open
$581,250 - $581,250

Mechanisms of Nucleosome Dynamics in Epigenetic Inheritance

open
$386,879 - $386,879

Imaging Protein Synthesis on the Ribosome using Single-Molecule FRET

open
$678,370 - $678,370

Advancing Low-Cost Synthetic Biosensor Arrays for Rapid Multiplex Biomarker Detection

open
$383,801 - $383,801

Molecular Organization and Function of Oocyte Spindles

open
$125,000 - $125,000

Chemical language models for peptide engineering

open
$310,750 - $310,750

De novo Design of Proteins for Catalysis and Fluorescence Imaging

open
$124,767 - $124,767

Essential of Essential: A Variational Graph Attention Framework for Predicting Gene Essentiality and Functional Substructures

open
$566,094 - $566,094

Defining molecular mechanisms of hypoxia-induced migration during would healing

open
$315,417 - $315,417

Computational methods for sub-cellular spatial transcriptomics with high gene coverage

open
$444,125 - $444,125

Tissue transcriptomics enabled by spectral binary barcodes

open
$2,102,360 - $2,102,360

Novel methods for detecting positive selection in mosquitoes

open
$113,464 - $113,464

Integrative Structural Biology in Viral RNA Synthesis Machinery

open
$437,250 - $437,250

Targeted Protein Degradation Utilizing Rpn-13

open
$448,510 - $448,510

Computational Methods for In-Situ Structure Determination using Cryo-ET

open
$482,750 - $482,750

Interrogating the roles of truncated/mutated inverted terminal repeat sequences in adeno-associated virus vectors in transgene stability through episome formation and host cell genome integration

open
$1,675,000 - $1,675,000

Research Framework for Innovation in Read Mapping

open
$315,005 - $315,005

Molecular basis and selectivity of signaling and transport across lipid membranes

open
$508,111 - $508,111

Dynamic RNA Folding and Function

open
$382,751 - $382,751

Developing Photoenzymes for Selective Chemical Synthesis

open
$165,366 - $165,366

Solvent-Driven Assembly of Intrinsically Disordered Peptides: Integrating Protein-Language Models with Atomistic-to-Mesoscopic Simulation

open
$391,250 - $391,250

Enhanced Sampling of Intracellular Protein Interactions with G-Protein-Coupled Receptors

open
$470,963 - $470,963

Development of Smoldyn

open
$317,439 - $317,439

Molecular Mechanisms of Non-muscle Myosin II Contractility

open
$430,383 - $430,383

AI-designed Nanobodies for Detection and Manipulation Applications Inside Living Cells

open
$2,096,292 - $2,096,292

Molecular modeling and theoretical characterization of protein dynamics and ligand binding

open
$399,391 - $399,391

Dissecting protein and lipid networks with membrane-centric proximity labeling

open
$125,000 - $125,000

Context-specific cellular networks in bacterial pathogens

open
$426,539 - $426,539

Computational interrogation of Epigenetic Regulation in Cellular Plasticity and Heterogeneity

open
$589,500 - $589,500

Mechanisms that establish a functional stem cell niche during organogenesis

open
$168,918 - $168,918

Photodynamic Biomaterials for Microphysiological Tissue Engineering

open
$398,464 - $398,464

Deciphering the regulation of germline ribosomal DNA maintenance

open
$429,262 - $429,262

Discovery and mechanism of lipid scramblases

open
$471,690 - $471,690

Mechanisms and Predictions of Interindividual Variability in Drug Pharmacokinetics and Adverse Drug Reactions

open
$388,750 - $388,750

Computational methods for elucidating the hidden contributions of Structural Variants to complex diseases

open
$391,526 - $391,526

Structure and Mechanism of Gene Regulation by Small Noncoding RNAs

open
$419,674 - $419,674

Comparative Study on Human Beta Defensin Type 2 and 3 Interaction with Model Bacterial Lipid Membranes

open
$597,254 - $597,254

Molecular priming of reverse migration in neutrophil subpopulations

open
$116,005 - $116,005

Optogenetic Control of mRNA Localization

open
$220,784 - $220,784

Nicotine-enhancement of sweetened alcohol consumption: A behavioral economic evaluation

open
$194,668 - $194,668

Exploiting trans-domain syntrophy for the reduction of obesity using biotherapeutic Christensenella

open
$226,357 - $226,357

Structural/functional characterization of TGFB superfamily signaling and regulation

open
$756,933 - $756,933

Natural variation of embryo development across the insect order of flies

open
$480,083 - $480,083

Investigating histone glycation as a new dynamic epigenetic mark

open
$528,000 - $528,000

Defining the function of spatiotemporal JNK activation in cell fate determination

open
$273,651 - $273,651

Biological roles and mechanisms of cell surface RNAs in human papillomavirus endocytic trafficking

open
$417,845 - $417,845

Advancing mechanistic understanding at membrane interfaces

open
$418,822 - $418,822

Mechanisms of the interplay between metabolism, chromatin regulation, and transcriptional control in ethylene signaling and stress responses in Arabidopsis

open
$429,650 - $429,650

Building Capacity in Biomedical Research at Xavier University

open
$389,203 - $389,203

Elucidating the Molecular Determinants of Functional Specificity in Intrinsically Disordered Proteins

open
$413,946 - $413,946

Elucidating the Mechanisms and Roles of RNA Editing and Sensing

open
$446,875 - $446,875

Systematic evaluation of competition between dsRNA binding proteins

open
$412,632 - $412,632

Harnessing Movement Variability to Treat and Prevent Motor Related Disorder

open
$1,113,750 - $1,113,750

Harnessing microglia-neuron communication to improve habituation in neurodevelopment disorders

open
$226,500 - $226,500

Program Evaluation, Machine Learning, and AI

open
$271,376 - $271,376

Selenium Metabolism in the Heart: Impact of High Fructose and Low Selenium

open
$198,560 - $198,560

A Platform for Arene Activation via Machine Learning and Small Molecule Catalysis

open
$74,632 - $74,632

Mechanisms of parasitic behavior manipulation in a model host

open
$463,375 - $463,375

The role of non-canonical nucleic acid structures in genome regulation

open
$363,191 - $363,191

Membrane-inspired lipid nanoparticles for cell-type-specific expression of programmable RNA

open
$445,049 - $445,049

Deciphering the molecular and neurogenetic mechanisms that modulate social behavior

open
$451,000 - $451,000

Control of biomolecular systems to guide cell phenotypes

open
$400,969 - $400,969

Metabolic regulation of innate immunity-dependent wound healing in situ

open
$321,304 - $321,304

Identifying regulatory mechanisms of ROS1 signaling

open
$1,409,649 - $1,409,649

In Vivo Metabolic Tagging and targeting of Long-Circulating Biomembranes

open
$1,385,652 - $1,385,652

Gasdermin-D tags mitochondria to serve as mobile propagators of inflammatory responses

open
$431,750 - $431,750

Exploiting structure-function of potassium channels for modulation

open
$392,500 - $392,500

Integrative Genomic Analyses of Human Evolution and Complex Traits in Africa

open
$688,506 - $688,506

Cost-effective workflow for efficient unsaturated lipidomics enabled by a novel ion chemistry

open
$1,329,188 - $1,329,188

Systemic Effects of Metabolic Enzyme Dysfunctions

open
$419,375 - $419,375

Functional Dynamics and Interactions of CYP19

open
$405,625 - $405,625

Discovery and application of new enzymes for amino acid and peptide modification

open
$451,000 - $451,000

Structure and Dynamics of Macromolecular Complexes

open
$501,165 - $501,165

The impact of demography and selection on the genetic architecture of human traits

open
$451,000 - $451,000

Mitochondrial transport and quality control in neurons

open
$423,500 - $423,500

Investigating regulatory mechanisms of in vivo transcriptional dynamics

open
$299,673 - $299,673

Impact of Sex Chromosomes and Hormones on Drug Metabolism and Transport

open
$336,355 - $336,355

Structure and Mechanisms of Mitochondrial Pyruvate Carrier (MPC)

open
$456,500 - $456,500

Structure and function of KATP channels

open
$429,000 - $429,000

Interplay between post-translational modification systems in Archaea

open
$383,750 - $383,750

Decoding the Mechanisms and Regulatory Networks of Plant U-Box/RING Ubiquitin Ligase Complexes under biotic stress

open
$390,881 - $390,881

Chemical Reactions to Advance Drug Discovery: Stereoselective Synthesis of Heterocycles and Late-Stage Functionalization for Mechanism of Action Studies

open
$433,780 - $433,780

Uncovering the molecular principles of intracellular electrochemistry

open
$410,520 - $410,520

Using high-valent dinuclear cobalt complexes to understand enzymatic bond activation and bond formation processes

open
$1,184,200 - $1,184,200

Technologies to study and control patterning and differentiation in multicellular development, a case study for multilayered arterial wall of controlled thickness

open
$656,500 - $656,500

Mechanisms and Control of O2 and C–H Activation within "Privileged" Enzyme Architectures

open
$750,554 - $750,554

Stress sensing by polycystin proteins

open
$452,051 - $452,051

Metabolic Regulation of Immunity in C. elegans

open
$390,000 - $390,000

Defining the building blocks of multicellularity: adhesion, recognition, and immunity

open
$411,285 - $411,285

Dietary Chelators in Metal Homeostasis

open
$430,375 - $430,375

Mechanisms of Protein Self-Assembly Coupled to Membrane Mechanics in the Cell

open
$420,936 - $420,936

Engineering radical enzymes for asymmetric olefin hydroalkylation

open
$335,924 - $335,924

Elucidation of Gd(III)-Ligand and Gd(III)-Protein Complexes for Development of Gd(III) Contrast Agents Using High-Frequency EPR Spectroscopy

open
$79,348 - $79,348

Molecular Mechanisms of Limb and Tail Regeneration in Axolotl

open
$422,500 - $422,500

The mast-cell-specific Mrgprb2 signaling in wound healing and scar formation

open
$303,082 - $303,082

ADAM-ephrin interactions in cell signaling and adhesion

open
$1,355,976 - $1,355,976

Dynamics of Motile Flagella in Fluid Media

open
$373,737 - $373,737

Molecular causes and physiological and behavioral consequences of extreme glucocorticoid levels in Peromyscus mice

open
$125,000 - $125,000

Deploying biosensors to accelerate pharmaceutical biocatalyst development

open
$125,000 - $125,000

Next-generation approaches for comprehensive mapping of post-translational modification landscapes

open
$375,000 - $375,000

R35 Investigate structure and function of human amyloid-peptide degrading proteases

open
$470,385 - $470,385

Biosynthesis, discovery, and biocatalytic production of halogenated nucleosides and nucleoside-sulfamates.

open
$397,158 - $397,158

Engineering Immunocompetent Systems for Modeling, Modulating, and Treating Inflammatory Diseases

open
$398,144 - $398,144

Computational systems for single-cell and spatial transcriptomics experiments

open
$413,001 - $413,001

Molecular Mechanisms Controlling Actin Cytoskeleton Dynamics

open
$924,095 - $924,095

Network-based models for continuous cell state inference

open
$433,750 - $433,750

New Frontiers in the Streamlined Synthesis of N-Unprotected Chiral Heterocycles and Amines via Organo- and Transition Metal Catalysis

open
$410,184 - $410,184

Experimental and theoretical analysis of principles underlying molecular and genomic mechanobiology

open
$428,064 - $428,064

Investigating Mechanisms Controlling the Development of Tim4+ Macrophages

open
$506,550 - $506,550

Identifying fundamental principles of evolutionary dynamics in multispecies microbiomes

open
$411,125 - $411,125

Cell signaling through O-linked glycosylation

open
$474,507 - $474,507

New chemical tools for the design of next generation antibody drug conjugates

open
$551,154 - $551,154

Discovery and Functional Validation of Hepatic eQTLs

open
$356,311 - $356,311

Catalytic mechanisms, regulation, and anti-fibrotic roles of the TMEM2 cell surface hyaluronidase

open
$1,677,007 - $1,677,007

Understanding autolysin function in Gram-negative bacterial growth and morphogenesis

open
$291,491 - $291,491

Prediction of reactivity in complex settings using machine learning

open
$125,000 - $125,000

Spatial Regulation of Plasma Membrane Signaling

open
$413,069 - $413,069

Epigenetic Regulation and Function of Imprinted Genes

open
$478,621 - $478,621

Real-Time Software-Hardware Integration for Dynamic Control of Tissue Mechanical Environments

open
$1,244,000 - $1,244,000

Tracing developmental signaling histories with imaging-based molecular recording

open
$433,125 - $433,125

Functions and Mechanisms of Bacterial Ser/Thr Kinases

open
$427,526 - $427,526

Deciphering the Role of CTR1 Oligomeric States in Copper Homeostasis and Neuronal Differentiation

open
$431,750 - $431,750

Investigating the biological functions, biosynthesis, and dynamic regulations of RNA chemical modifications

open
$423,500 - $423,500

Engineering liposomal DNA-driven membrane fusion for efficient protein, nucleic acid, and lipid delivery

open
$995,204 - $995,204

Defining the regulatory control of desiccation tolerance in Acinetobacter baumannii

open
$451,000 - $451,000

Accurate and Efficient Solvent Models for Molecular Simulations: Methods and Biological Applications

open
$410,605 - $410,605

Genetic and Molecular Mechanisms Connecting Mechanotransduction to Lipid Metabolism

open
$320,750 - $320,750

Paragons of Conformational Control in Metalloenzyme Reactivity

open
$614,467 - $614,467

Cytoskeletal force-sensing mechanisms

open
$395,499 - $395,499

Cell and developmental mechanisms of animal responses to intracellular beneficial microbes

open
$441,375 - $441,375

Cell Context and Variant Effects: Multiplexed Assays for Synthetic Protein Innovation

open
$492,931 - $492,931

Modeling Cellular Membranes and Associated Proteins with Improved Force Fields

open
$405,390 - $405,390

Mechanistic studies of Metal Ion-Induced Transthyretin Misfolding and Toxic Oligomer Formation

open
$566,250 - $566,250

Defining the role of linear and nonlinear forces in regulating cell metabolism

open
$432,417 - $432,417

Regulatory nucleic acid interactions and telomere complexes

open
$495,480 - $495,480

Understanding mechanisms of RNA polymerase II transcriptional termination

open
$307,854 - $307,854

Role of mRNA internal 2′-O methylation in post-transcriptional regulation

open
$440,000 - $440,000

Quantitative Analysis Research Core (QuARC)

open
$169,457 - $169,457

Discovery of Chemical Probes and Therapeutic Leads, Phase 3, Admin Core

open
$788,742 - $788,742

Elucidating the mechanisms underlying DNA double-strand break repair

open
$390,000 - $390,000

Evolutionary and functional impact of common genomic structural variations

open
$401,914 - $401,914

Addressing the complexity and plasticity of heterotrimeric G protein signaling

open
$694,875 - $694,875

IMSD AT HUNTER COLLEGE, CUNY

open
$558,516 - $558,516

Catalytic C-C Coupling via Hydrogen Transfer

open
$425,960 - $425,960

Structural study of direct associations between cellular RNA polymerase and regulatory factors during the transcription cycle

open
$451,802 - $451,802

Coordination of gene expression and molecular function in known pathways

open
$53,974 - $53,974

Autism & Self-regulation: Tele-Assessment of Autonomic Psychophysiological correlates (ASAP)

open
$226,500 - $226,500

Mimics of Enzymes and Antibodies for Glycans and Other Biological Targets

open
$382,500 - $382,500

Unraveling effects of gut and blood microbial signatures on immune phenotypes and organ dysfunction in sepsis

open
$403,750 - $403,750

Investigating the in vivo regulation of Dynein activity

open
$42,545 - $42,545

Harnessing the orthogonality of fluorine for advanced biomaterials and biotechnologies

open
$468,872 - $468,872

Roles of microRNAs in animal development

open
$387,500 - $387,500

Dynamics and mechanisms of long-range enhancer activity

open
$76,780 - $76,780

Mechanism by which the Grp94 molecular chaperone folds insulin-like growth factors

open
$433,342 - $433,342

Catalytic and Regulatory Mechanisms of Heme-based Dioxygenases

open
$861,420 - $861,420

Structural bases for protein synthesis quality control

open
$375,420 - $375,420

Long-read strategies for elucidating transcriptome complexity and advancing genomic medicine

open
$445,000 - $445,000

Automated Microfluidics: Advancing Cell Culturing through Non-Sacrificial Analysis and Heterogeneous Microenvironments

open
$295,038 - $295,038

Mechanisms of recruitment and roles of the BET family chromatin readers in transcription initiation

open
$341,000 - $341,000

Ion laboratory for the elucidation of macromolecular assembly heterogeneity

open
$340,920 - $340,920

Learning and Achievement in Biomedical Sciences

open
$210,090 - $210,090

PTM-driven mechanisms of cell signaling

open
$423,500 - $423,500

Chemistry-Biology Interface Predoctoral Training Program

open
$213,180 - $213,180

Predoctoral Training Grant in Pharmacology and Molecular Medicine

open
$340,192 - $340,192

UC San Diego Medical Scientist Training Program

open
$60,545 - $60,545

T32 Predoctoral UNR Interdisciplinary Basic Biomedical Sciences Training Program

open
$170,400 - $170,400

Uncovering how chaperones assist in protein folding and preventing toxic protein aggregates

open
$272,596 - $272,596

Chemoenzymatic Strategies for Molecular Discovery and Asymmetric Synthesis

open
$585,000 - $585,000

Bioluminescent FAK Sensor and Genome-Wide CRISPR Knockout Screen to Identify Regulators of Cellular Adhesion

open
$144,961 - $144,961

Mechanisms of Circadian Entrainment and Plasticity

open
$435,875 - $435,875

Heme-Based Immune Dysregulation in Critical Illness

open
$402,500 - $402,500

T32 Transdisciplinary Training in Biomedical Science and Bioengineering at the University of Rhode Island

open
$213,180 - $213,180

Decoding RNA Localization and Local Translation: Key Mechanisms of Cellular Adaption and Function

open
$466,125 - $466,125

Defining microbial metabolic interactions in polymicrobial environments

open
$1,921,875 - $1,921,875

Technology Developments in Biomedical Mass Spectrometry

open
$423,330 - $423,330

High speed, high information content single-molecule techniques for studying protein interactions and organizations in cells

open
$335,712 - $335,712

Can one size fit all? - High-Resolution 3D Genome Spatial Organization Inference with Generalizable Models

open
$332,258 - $332,258

PARP-1 Degradation for PARP-Related Diseases

open
$151,000 - $151,000

A Real-Time Mass Spectrometry Platform for In-Process Monitoring and Cell State Analysis

open
$302,671 - $302,671

Molecular Mechanisms Underlying TRPM3 Regulation in the Cell Membrane

open
$410,601 - $410,601

Drivers of adaptation and colonization within individual human microbiomes

open
$557,900 - $557,900

Cooperative Catalysis Using Earth Abundant Metals

open
$147,025 - $147,025

Understanding metabolic and regulatory control of antibiotic production in filamentous actinobacteria

open
$416,050 - $416,050

Mechanisms of compartmentalized signaling in electrically excitable cells

open
$423,500 - $423,500

Unmask the roles of Mask as a mTOR-independent Autophagy-Promoting Factor

open
$375,000 - $375,000

Novel Burn Sepsis Prognostic Strategies: Deciphering Early Immune Progenitor Shifts in Burn Sepsis Development and Modulation of Host Burn Response through Angiopoietin-Tie Signaling

open
$423,500 - $423,500

Enzyme-encapsulated protein frameworks for optimized cascade biocatalysis

open
$134,932 - $134,932

Geometrical Regulation of Collective Cellular Responses in Three-Dimensional Space and Time

open
$443,878 - $443,878

Medical Scientist Training at UMCMS

open
$1,003,507 - $1,003,507

Decoding Positional Epigenetic Memory

open
$3,125,817 - $3,125,817

The transcription factor basonuclin-1, a new player in the progression of triple-negative inflammatory breast cancer

open
$149,000 - $149,000

pan-XLSM: an AI-powered microscopy platform for imaging and analysis of highly expanded tissue samples

open
$1,416,590 - $1,416,590

Hypertensive Toads: Investigating the Physiological and Evolutionary Pathways to Salt Tolerance in Amphibians

open
$431,750 - $431,750

Investigating stem and progenitor cell quality assurance in development andregeneration.

open
$412,500 - $412,500

Targeting Membrane Environments: The Role of Oleate Hydratase (OhyA) in Lipid-Protein Interactions Across Microbial Communities

open
$406,652 - $406,652

Engineering lipid nanoparticle platform for selective and enhanced delivery in vivo

open
$375,633 - $375,633

Acquisition of a Triple Quadrupole Mass Spectrometer

open
$245,380 - $245,380

Translate Membrane Structure Into Protein Functions.

open
$428,255 - $428,255

Regulation of gene transcription and DNA replication by chromatin readers from the BET family

open
$468,875 - $468,875

Metabolic Control of Membrane Lysis

open
$453,750 - $453,750

Regulation of the mitotic DNA damage response

open
$1,943,750 - $1,943,750

Deciphering novel cell death mechanisms and metabolic reprogramming in response to microenvironmental stress.

open
$446,875 - $446,875

Gram-positive secretion chaperone-client interactions

open
$401,939 - $401,939

Single molecule dissection of Arp2/3 complex activity and regulators in living cells

open
$2,041,875 - $2,041,875

High-resolution confocal fluorescence microscope

open
$245,258 - $245,258

The Meharry Medical College Medical Scientist Training Program (MMC-MSTP)

open
$118,090 - $118,090

Engineering Modular Protein Inhibitors for Selective Targeting of Pathological Biomolecules

open
$400,178 - $400,178

Acquisition of an Ultracentrifuge for Biochemistry, Cell Biology and Nanoscience Research

open
$98,871 - $98,871

Syntheses of homogeneous proteoglycan like glycopeptide and glycoprotein libraries for microarray studies

open
$417,243 - $417,243

Revealing the Molecular Basis of Microtubule-Intermediate Filament Interactions.

open
$528,000 - $528,000

DMS/NIGMS1: Unravel the connection between deformability and motility of eukaryotic cell through a

open
$189,854 - $189,854

Understanding the Metabolic Regulation of Immune Responses to Bacterial Infections

open
$2,158,750 - $2,158,750

Unraveling the Biomolecular Corona on Locally Delivered Nanomedicines

open
$391,162 - $391,162

DMS/NIGMS 2: Novel Statistical Methods, Algorithms, and Pipelines for Learning Omits Data with Complex Heterogeneity

open
$333,076 - $333,076

Decoding cis-regulatory element activity through deep learning frameworks

open
$460,625 - $460,625

Quantitative Mechanoporation for High Throughput Cell Surgery

open
$380,771 - $380,771

Scripps Research Translational Chemical Biology

open
$404,450 - $404,450

Mechanisms of Bacterial Lysis Sensing

open
$417,450 - $417,450

National Center for Translational and Developmental Proteomics

open
$1,761,867 - $1,761,867

The Effects of Cue Precision on Medical Imaging Interpretation

open
$131,800 - $131,800

Somatic mosaicism across mouse tissues during different life stages

open
$423,500 - $423,500

RESTEP in AZ: Regenerative Engineering, Science, and Technology Education Program in Arizona

open
$426,360 - $426,360

AIHEC Circle of Health Research Training

open
$482,421 - $482,421

Synthetic Biology and Biotechnology (SB2) Predoctoral Training Program

open
$426,360 - $426,360

Impact of ecological interactions on mutant fitness and evolution in microbes

open
$431,750 - $431,750

Developing Digital Speech Biomarkers of Bulbar Disease Decline in Spanish-Speaking persons with Amyotrophic Lateral Sclerosis

open
$149,695 - $149,695

Training Program in Molecular Biophysics of Complex Systems

open
$148,680 - $148,680

Using catalyst speciation to control reactivity and address longstanding challenges in cross coupling reactions

open
$439,203 - $439,203

Advanced computational approaches for single-cell multi-omics integration

open
$437,250 - $437,250

Advancing Disease Modeling through Mathematical Frameworks: Leveraging Single-Cell Spatial Data to Uncover Tissue-Specific Pathways and Immune Responses

open
$406,250 - $406,250

Deciphering the cellular origins and impact of toxic formaldehyde in mammalian cells

open
$2,070,575 - $2,070,575

Designing a Comprehensive Machine Learning-driven Prescriptive Clinical Decision Support System for Shock and Associated Critical Care Conditions

open
$433,710 - $433,710

Clarifying engineered bioabsorbable metals tissue-biomaterial interface and regeneration

open
$429,000 - $429,000

DNA Protein Cross-Links: Metabolic Sources and Repair

open
$1,843,775 - $1,843,775

Developing a Multi-Organ Multi-Omics Computational Framework for StudyingMammalian Iron Systems Biology

open
$486,750 - $486,750

Role of nitrate in microbiota ecology

open
$442,750 - $442,750

Understanding the Platelet-CD8+ T Cell Interactions in Sepsis

open
$504,644 - $504,644

Integrating frequency and phenotypic association data to improve interpretation of rare genetic variants

open
$412,500 - $412,500

Mechanism of Smc5/6-mediated protein sumoylation in DNA repair

open
$148,228 - $148,228

Novel pathways in heterochromatin regulation

open
$426,250 - $426,250

Research and Career Training for Cellular, Biochemical and Molecular Scientists

open
$213,180 - $213,180

Empowering Genomics Educators: Scalable and Effective Training Models to Build a Skilled Biomedical Workforce through Course-based Undergraduate Research Experiences

open
$541,629 - $541,629

Developing sulfonium lipid nanoparticles as a novel platform for mRNA delivery

open
$448,250 - $448,250

Modulation of Breast Cancer Metastasis Using Bone-Targeted Delivery of a Small Anti-Cancer Peptide

open
$174,532 - $174,532

A Mentoring and Skills Development Training Program in One Health

open
$536,069 - $536,069

Pseudouridine detection with single-base resolution in a multiplexed epitranscriptomics assay

open
$1,146,785 - $1,146,785

Molecular mechanism of heterochromatin formation

open
$408,367 - $408,367

High Throughput End-to-End Design of Quantitative Phase Microscopy based on Customizable Nano-Optics

open
$1,963,850 - $1,963,850

Novel mechanisms of purine regulation and their roles in human pathophysiology

open
$125,000 - $125,000

RNase functions in post-transcriptional gene regulation

open
$317,526 - $317,526

Advancing Sepsis Biology and Care Through the Power of Modern Biobanks

open
$462,981 - $462,981

Cellular and Molecular Biology Training Program

open
$1,600,351 - $1,600,351

Molecular Basis for Transmembrane Conduction & Signaling

open
$576,104 - $576,104

Training in BioMolecular Pharmacology

open
$426,360 - $426,360

Leveraging diverse ancestry and environmental variables to understand the evolution and architecture of complex traits

open
$413,300 - $413,300

Training Program in Cellular and Molecular Membrane Biology

open
$416,240 - $416,240

Uncovering the rules governing mobile genetic element spread

open
$408,375 - $408,375

Modeling Aneuploidy-Driven Phenotypes Across Tissues

open
$460,625 - $460,625

Chronic Ankle Instability and Aging: Combined Effects on Physical Function, Joint Health, and Daily Activity

open
$154,969 - $154,969

Tri-Institutional PhD Program in Computational Biology & Medicine

open
$534,450 - $534,450

Drug Action, Metabolism and Kinetics Training Grant

open
$352,624 - $352,624

Investigating the crosstalk between DNA damage and innate immune signaling networks in macrophages

open
$184,375 - $184,375

The role of host mRNA cleavage by RNase L in viral infections

open
$249,000 - $249,000

Nuclear-Mitochondrial Mismatch in Mitochondrial Function and Disease

open
$507,544 - $507,544

Stress response signaling as a metabolic sensor in reproduction

open
$248,975 - $248,975

Data-Science Guided Study and Design of Phosphoranyl Radical-Mediated Reactions

open
$75,052 - $75,052

Improving accessibility and efficacy of in vivo forward genetic screening

open
$386,013 - $386,013

Picturing Possibilities and Envisioning Selves; PiPES3

open
$265,343 - $265,343

Building community-centered health research capacity in a Tribal college setting: Salish Kootenai College NARCH

open
$256,348 - $256,348

In Vitro Reconstitution of Centralspindlin-Mediated Transport

open
$145,500 - $145,500

Chemical Synthesis of Biologically Significant Polysaccharides via LivingPolymerization

open
$325,500 - $325,500

The endocytic requirements for mechanosensitive Notch activation in vivo

open
$555,000 - $555,000

Synthetic Biology Approaches to Engineer Lactococcus lactis for Targeted Delivery of Therapeutic Lasso Peptides

open
$460,166 - $460,166

Mechanistic studies into regulation of the copper chaperone CCS by phosphorylation

open
$577,500 - $577,500

Enantioselective desymmetrizing hydroamination to synthesize complex all-carbon quaternary stereocenter containing saturated heterocyclic structures

open
$548,701 - $548,701

Nanoscale biosensor arrays for biomolecule analysis

open
$316,250 - $316,250

Computational analysis of transcriptome rearrangements in SARS-CoV-2

open
$151,870 - $151,870

Developing Next Generation Eutectic Solvents for Biomedical Applications

open
$529,359 - $529,359

The Center for Open Bioimage Analysis

open
$728,992 - $728,992

Necessity of RNA degradosome assembly in Sinorhizobium meliloti for effective symbiosis

open
$155,000 - $155,000

Additive Manufacturing Wearable Magnetic Sensors: Revolutionizing Cardiac Health Monitoring with Machine Learning for Arrhythmia Classification

open
$119,870 - $119,870

Improving red blood cell storage for trauma resusciation

open
$405,000 - $405,000

Decoding Gene-Environment Interactions in Complex Traits via Multi-Omics Approaches

open
$258,986 - $258,986

Investigation of how RNA-directed feedback loops coordinate wound healing and regeneration

open
$428,600 - $428,600

De novo evolved lipid transport and processing mechanisms interfacing human cells

open
$385,000 - $385,000

Population Genomics Across Global Populations: Flexible Methods for Inference and Detecting Rare Recessive Variation

open
$395,200 - $395,200

Precision, Functional Glyconanoassemblies through Supramolecular Design

open
$347,086 - $347,086

Plasmonic Nanoantenna Enhanced Ultrasensitive Fluorescence Immunoassay Enabled by Super-hydrophobic Surface

open
$147,091 - $147,091

Z-DNA and its role in RNA polymerase III transcriptional regulation

open
$404,569 - $404,569

Enhancing our understanding of intercellular communication to achieve programmable regeneration

open
$431,750 - $431,750

Dissect Human Primordial Germ Cell Development Using Stem Cell Models

open
$2,043,430 - $2,043,430

Modeling Receptor-ligand interactions for Drug Discoveryfrom Cryo-EM data using AI

open
$217,941 - $217,941

Novel regulation of fibrinogen expression and function

open
$425,302 - $425,302

Selective Transformations of Common Feedstocks to Functionalized Amines and Heterocycles

open
$552,403 - $552,403

Decoding epigenetic adapters of cell state

open
$394,434 - $394,434

Investigating the impact of RNA structural dynamics on function of the lncRNA FIRRE

open
$2,129,028 - $2,129,028

Single-molecule imaging and mechanisms of crossover regulation on meiotic chromosomes

open
$404,058 - $404,058

A continuous evolution platform for cyclic peptide discovery

open
$1,827,200 - $1,827,200

Metabolic control of extracellular matrix synthesis

open
$451,000 - $451,000

Developing methods for high-throughput deep characterization of extracellular RNA, DNA, and vesicles in body fluids

open
$390,000 - $390,000

Mechanisms, Structures and Engineering of Flavonoid-producing Dioxygenase Enzymes

open
$147,000 - $147,000

Robust Multivariate Methods for Analyzing Pathway Interactions and Pathway-Phenotype Associations in Bulk and Single-Cell RNA-seq Studies

open
$2,053,480 - $2,053,480

Using Ae. aegypti as a model to understand the genomic basis of rapid and repeated evolution

open
$392,500 - $392,500

Investigating anti-neuroinflammatory therapeutics for polysubstance use disorders

open
$142,100 - $142,100

Harnessing Sleep and Biological Rhythms to Improve Postoperative Recovery

open
$453,750 - $453,750

Towards precision risk stratification, diagnosis, and treatment: statistical and computational machinery for synthesizing information across massive, diverse sources of genomic and clinical data

open
$426,479 - $426,479

Innovative Multiscale Modeling Techniques for Membrane-Bound Proteins

open
$369,500 - $369,500

Ultra-small scale assay of enzyme inhibition for drug discovery

open
$295,861 - $295,861

Precise GI Drug Delivery and Modeling with Pharmacomicrobiomics

open
$427,625 - $427,625

Efficient algorithms for searching large mass spectral databases

open
$433,125 - $433,125

Predoctoral Training in the Physiology of Human Health and Disease (PHHD)

open
$175,452 - $175,452

Pathological Autoantibodies Contribute to Immune Suppression in Sepsis

open
$410,000 - $410,000

Asymmetric nucleosome substrates to advance the study of the histone code

open
$1,264,176 - $1,264,176

Seahorse XFe24 Metabolic Flux Analyzer

open
$249,818 - $249,818

Administrative Supplement to Promote Re-Entry in Health-Related Research Careers

open
$91,964 - $91,964

Acquisition of Monolith X instrument, a Microscale thermophoresis instrument, for research and teaching at Hampton University

open
$249,526 - $249,526

Functionalized Receptors for Efficient Epitope Recognition

open
$535,867 - $535,867

Mechanisms of Telomere Maintenance and Protection

open
$531,584 - $531,584

Regulators of The Unfolded Protein Response Signaling

open
$563,880 - $563,880

Internal water dynamics in hydration shells of amyloid-beta species

open
$466,972 - $466,972

Structure and function of glycolytic enzymes and their cellular regulation

open
$382,500 - $382,500

RAMP-altered class B GPCR hormone binding and signaling

open
$389,310 - $389,310

Novel mechanisms and vascular interactions mediating the cardiometabolic benefits of exercise

open
$144,500 - $144,500

Elucidating the roles of protein glycosylation in prokaryotes through functional glycoproteomics

open
$186,354 - $186,354

Treatment of Malaria-Associated Acute Kidney Injury and Progression to Chronic Kidney Disease

open
$131,613 - $131,613

Functional dynamics of essential bacterial proteins and EPR technology development

open
$506,105 - $506,105

Sequence transformations and microbiology: theory, tools, & discovery

open
$412,295 - $412,295

Simplifying the description, not the system: Advanced ecological theory for real-world microbiomes

open
$326,550 - $326,550

Catalytic Radical Processes for Stereoselective Chemical Synthesis

open
$620,000 - $620,000

Improving Characterization of Individualized Treatment Effects in Critical Illness

open
$437,250 - $437,250

Development and Commercialization of Sialoglycan-Recognizing Probes

open
$306,782 - $306,782

Investigating local protein co-translational folding in situ with high spatiotemporal resolution

open
$1,998,288 - $1,998,288

Redefining Nanomedicine Beyond One-Size-Fits-All: Uncovering Mechanisms of Sex Differences and Female Life Stages in Drug Delivery

open
$1,833,094 - $1,833,094

Capillaric microfluidics for integrated, self-powered, and self-regulated sample preparation in miniaturized mass spectrometry systems

open
$427,625 - $427,625

Enzyme-Inspired Multimetallic Cooperativity: Leveraging Metal Pairing Effects for Heightened Reactivity

open
$2,011,480 - $2,011,480

Myeloid-Derived Suppressor Cells in Immunological Endotyping and Intervention of Chronic Critical Illness after Sepsis

open
$422,125 - $422,125

Integrative Computational Models for Decoding Disease Mechanisms and Predicting Drug Synergies in Spatial Transcriptomics

open
$423,616 - $423,616

Understanding the molecular function and substrate specificity of palmitoyltransferases in regulating behavior

open
$390,000 - $390,000

Mechanisms of Toll/interleukin1 receptor (TIR) domain function in cell death and immunity

open
$376,444 - $376,444

Mechanisms regulating inflammatory fibroblasts in wound healing

open
$2,157,780 - $2,157,780

Molecular mechanisms of lysosome remodeling in response to cellular stress

open
$407,562 - $407,562

Advancing Free Energy Methods for Drug Design

open
$422,958 - $422,958

Investigating the mechanobiology of multicellular morphogenesis

open
$365,077 - $365,077

Phylodynamics of Cell Populations

open
$2,252,479 - $2,252,479

Decoding Mitochondrial AAA Protease Specificity

open
$382,931 - $382,931

Small molecule signaling in regulation of gut microbiota structure and colonization resistance

open
$2,065,745 - $2,065,745

Directing and Deciphering Macrophage Polarization through Biologically-Inspired Surface Design of Polymer Brush-Coated Cell Culture Substrates

open
$1,993,748 - $1,993,748

Mechanisms of cell fate specification by glycosylation

open
$2,252,479 - $2,252,479

Discovery and application of halogenases for medicinal chemistry

open
$423,975 - $423,975

Xenobiotic induction mechanisms affecting pharmacokinetics and pharmacodynamics among medically complex children, adolescents, and young adults.

open
$2,117,500 - $2,117,500

Probing the Effects of Pathological Conditions on AKT

open
$2,011,691 - $2,011,691

A Molecular Recognition Guidebook for Targeting Protein Loops with Covalent Ligands

open
$387,857 - $387,857

Quantum sensor-enabled nanoscale magnetic resonance

open
$394,000 - $394,000

Understanding the Impact of Xenobiotic Metabolism on the Gut Microbiome and Resilience against Gastrointestinal Pathogens

open
$353,500 - $353,500

A platform for the rapid development of protein binders

open
$306,872 - $306,872

Coordinated Control of Metabolism by Enzymes and Transporters

open
$398,750 - $398,750

Probe and Target Lysyl oxidases (LOXs) in Cancer

open
$391,951 - $391,951

Structural and Mechanistic Bases for Ligand Specificity of α1-Adrenergic Receptors

open
$377,123 - $377,123

Digital PCR System

open
$97,764 - $97,764

Active non-viral nuclear delivery of DNA templates independent of mitosis

open
$349,952 - $349,952

Mapping biophysical effects of the cellular environment on p53 and PTEN stability and aggregation

open
$183,125 - $183,125

Optimizing Nanobody Sequence Design through Multi-Objective Engineering

open
$186,250 - $186,250

PhysioSim: Innovative Physiology Simulation Education Kits for Pre-College Students and Teachers

open
$969,833 - $969,833

Non-canonical roles for AMPK and TBK1 in amino acid sensing by mTOR

open
$388,701 - $388,701

Methods for Radical Hydroamination via Boryl Radical Chemistry

open
$249,000 - $249,000

The Mechanism and Function of Organelle Hitchhiking

open
$75,520 - $75,520

Designing chemoenzymatic approaches to biologically active molecules enabled by enzyme library screening

open
$249,000 - $249,000

BIOPHYSICAL CUES SHAPING MACROPHAGE AND T-CELL FUNCTIONS

open
$249,000 - $249,000

Redox Properties and Partners of the Yeast Thioredoxin Reductase Trr1

open
$316,797 - $316,797

Mechanistic studies of E3 Ub ligase in peroxisomes and mitochondria

open
$686,324 - $686,324

Investigating NEK10 as a myosin light chain kinase

open
$458,998 - $458,998

Dynamic mechanisms of transcriptional coactivator function in Notch signaling

open
$249,000 - $249,000

Heterochromatin Repair Mechanisms: a Chromatin Perspective

open
$451,259 - $451,259

Readily deployable technology for reproducible cryogenic sample time-resolved electron microscopy (cryoTREM)

open
$2,113,889 - $2,113,889

Time-lapse epigenome profiling in support of next generation cellular reprogramming

open
$1,399,500 - $1,399,500

Early detection and inference for emerging infectious agents in data-sparse settings

open
$2,056,250 - $2,056,250

Studying lysine aminoacylation of human metabolic enzymes

open
$562,500 - $562,500

Discovery of Chemical Probes and Therapeutic Leads, Phase 3, Analytic Core

open
$241,621 - $241,621

Differential stress responses of organelles to nutritional versus ER stress

open
$414,159 - $414,159

Understanding the role of anesthesia in perioperative organ injury via wireless soft implants

open
$441,626 - $441,626

The role of the epigenome-microbiome axis in phenotypic plasticity

open
$375,929 - $375,929

Molecular mechanisms of lipid transfer by bridge-like lipid transfer proteins

open
$399,081 - $399,081

Mammal-microbial coevolution: mechanisms and health implications

open
$361,416 - $361,416

Decoding Enzyme Sequence-Activity Relationships via Generative AI for Rational Enzyme Design

open
$422,125 - $422,125

Machine Learning Powered Platform for Discovery of Peptide Ligands for Peptide-Drug Conjugates

open
$404,032 - $404,032

Systematic understanding of RNA-centric mechanisms of gene regulation in chromatin

open
$459,250 - $459,250

Investigating the Mechanisms of Brain-Heart Communication Under Stress

open
$420,834 - $420,834

Linking Conformational Dynamics to Activity Impairment of Disease-associated Human Enzymes

open
$417,498 - $417,498

Mechanisms of cell-autonomous plasma membrane stabilization and repair in plants

open
$478,269 - $478,269

Defining mechanisms that underlie well-controlled translation initiation

open
$484,000 - $484,000

Mechanisms and Regulations of Neutral Lipid Metabolism

open
$416,398 - $416,398

Deciphering and predicting ecologically sensitive gut microbiome contributions to human metabolic health

open
$421,250 - $421,250

Structural dynamics of the human mitochondrial pyruvate carrier associated with transport and inhibition

open
$1,925,000 - $1,925,000

Genetic inference and prediction in diverse, multi-ancestry cohorts

open
$318,956 - $318,956

Structurally Decoding the Biosynthetic Logic of Modular Polyketide Synthases

open
$456,500 - $456,500

Protein aggregation controlled by disaggregases.

open
$2,282,500 - $2,282,500

Structure and mechanism of how cells read and repair the genome

open
$525,416 - $525,416

Development of TACA Glycan Library and Related Glycomics Products

open
$313,963 - $313,963

Modulation of ion channels by lipids and protein folding helper enzymes

open
$398,444 - $398,444

Developing and Discovering Covalent Inhibitors through Fragmentation-First Experimentation

open
$2,503,299 - $2,503,299

Physical Biology of the Cellular Glycocalyx

open
$435,769 - $435,769

An Antimicrobial Dermal Regeneration Template for application in challenging wound environments

open
$349,892 - $349,892

Molecular Architecture and Function of synaptic AMPA receptor complexes

open
$385,639 - $385,639

The Molecular Basis for Myosin-10 Regulation

open
$1,906,969 - $1,906,969

DMS/NIGMS 1: Improving Modern Diagnostics: Detecting and Genotyping of Evolving Viral Pathogens

open
$200,000 - $200,000

Cellular and molecular determinants of amniote regenerative potentials.

open
$351,920 - $351,920

Unraveling the Role of The Fibrinolytic-Inflammatory Axis in Severe Trauma Adverse Outcomes: From Acute Organ Dysfunction to Chronic Disability

open
$454,336 - $454,336

Chemical proteomics strategies for quantifying inflammatory protein networks and modifications

open
$360,188 - $360,188

Develop a technology for whole-genome sequencing of RNA-DNA triplexes

open
$435,412 - $435,412

Bioorthogonal Chemical Probe for Live Cell Imaging of Lactylation

open
$378,672 - $378,672

Linker histone H1 and variant histone H2A.Z interactions in gene silencing and chromosome segregation

open
$598,500 - $598,500

Deciphering the Interactome and Functions of Disordered Microproteins

open
$384,527 - $384,527

Mechanisms of Recombinational DNA Repair

open
$305,927 - $305,927

Bacterial epigenetic memory of heat shock response

open
$137,000 - $137,000

Platform for Analyzing the Mutations associated with Schizophrenia (PAMS)

open
$137,060 - $137,060

Automated widefield fluorescence microscopy system

open
$248,580 - $248,580

Inducing Apoptosis in Castration- Resistant Prostate Cancer by Targeting Sphingomyelin Synthase 1 for mono and combination therapy

open
$138,677 - $138,677

Real-Time Cell Analyzer Equipped with Impedance and Imaging Detectors

open
$234,021 - $234,021

Novel Approaches to Identifying and Targeting Sepsis-Associated Endothelial Dysfunction

open
$187,410 - $187,410

Expanding the understanding of tRNA lifecycle under cellular stress

open
$78,040 - $78,040

Structural Investigation of the Central Components of the CD4+ T Cell Immunological Synapse

open
$54,538 - $54,538

Diastereodivergent Piperidine Synthesis via Hydrogen-Bond Donor Catalysis

open
$74,632 - $74,632

Design of Phosphoranyl Radical α-scisson Reactions Enabled by Photoredox Catalysis and 1,5-Hydrogen

open
$74,632 - $74,632

SAFE Futures: Supporting American Indian and Alaska Native (AIAN) Maternal Health through Virtual Engagement and Community Empowerment

open
$232,500 - $232,500

CHEMICAL STRATEGIES FOR CONFORMATIONAL CONTROL OF BIOACTIVE PEPTIDES

open
$385,671 - $385,671

Regulation of selenium metabolism and stress response

open
$2,110,625 - $2,110,625

A New Mode of Inhibition to Target Protein-Protein Interactions by Ligand-Transferred Oxidation

open
$462,000 - $462,000

Contemporary Human Models of Postoperative Pain: A Biopsychosocial Investigation in General Surgery

open
$371,871 - $371,871

The crossroads between the methionine cycle and the coronavirus RNA capping.

open
$2,094,250 - $2,094,250

Rhythms of Resistance: Unraveling the impact of natural circadian variation on immunity

open
$2,138,125 - $2,138,125

Distinct responses to hypoxia in striated muscle

open
$355,972 - $355,972

Mentorship Education to Advance Biomedical Research Career Development

open
$541,331 - $541,331

Biological role and pharmacology of EXPERA family proteins and their effect onsterol homeostasis

open
$2,102,917 - $2,102,917

Dynamics of cell-matrix mechanical communication during morphogenesis

open
$399,198 - $399,198

How the endocytic network mediates specificity of cell signaling

open
$419,850 - $419,850

Liquid Chromatography - Triple Quadrupole Mass Spectrometer System

open
$249,975 - $249,975

Molecular mechanisms of ribosome-mediated kinase signaling

open
$2,136,693 - $2,136,693

Deciphering Mechanosignaling Using Multi-fluorescence Biomembrane Force Probe

open
$440,000 - $440,000

New Catalytic Technologies Impactful to Synthesis of Pharmaceuticals

open
$386,617 - $386,617

Calcium sensing and mitochondrial homeostasis

open
$387,500 - $387,500

Great Lakes NARCH 13 Gikendan Gegoo Endaso Giizhig

open
$903,484 - $903,484

Probing and controlling chirality across scales using nanophotonic platforms

open
$396,500 - $396,500

Measuring compartmentalized metabolism of cofactors

open
$277,375 - $277,375

Development of Haloperoxidase Enzymes for New Applications in Chemical Synthesis

open
$2,021,315 - $2,021,315

Accelerated, scalable same-day microfluidic sequential gene editing for allogeneic cell therapy

open
$314,000 - $314,000

Statistical approaches for integrating multi-view, multi-section and multi-sample spatial transcriptomics data to decipher disease mechanisms

open
$384,722 - $384,722

Chemoenzymatic methods and reagents to access affordable (iso)globo- and(neo)lacto-glycosphingolipids

open
$315,000 - $315,000

Multispray Technology for Studying Biomolecular Interactions

open
$1,000,000 - $1,000,000

Feasibility and Acceptability of Technology-Assisted Overdose Response Interventions in Rhode Island

open
$212,249 - $212,249

Investigating the emergent dynamics of actin filament branch formation and aging using a multiscale computational approach

open
$75,052 - $75,052

How do stem cells decode proto-oncogenic Ras signaling to eliminate hyper-proliferative cells in vivo?

open
$78,040 - $78,040

Elucidating the Dynamics and Function of Long-Range Polycomb Interactions

open
$75,520 - $75,520

Molecular lanterns for multiplexed imaging of RNA dynamics

open
$1,890,339 - $1,890,339

Determining subcellular coordination of Signal Recognition Particle assembly

open
$33,538 - $33,538

Mechanisms and Structures of Pseudomonas aeruginosa hibernating ribosomes

open
$1,153,952 - $1,153,952

Regulatory mechanisms linking protein synthesis and degradation

open
$75,520 - $75,520

DMS/NIGMS 2: Building and Testing a Graph Theory Toolbox for Uncovering Redundant Pathways in Genetic Interaction Networks

open
$256,616 - $256,616

Understanding the linked roles of polyphosphate and the stringent response in bacterial physiology

open
$78,220 - $78,220

General anesthetic modulation of memory through alpha5-GABA(A) receptors on Lamp5-expressing interneurons

open
$334,325 - $334,325

Regulation of Mammalian Meiotic Decision by Glutamine Transporter Slc38a2

open
$952,117 - $952,117

Understanding MORF-mediated hematological gene regulatory mechanisms

open
$387,536 - $387,536

DMS/NIGMS 2: Multiscale modeling of stimuli responsive drug delivery systems

open
$98,190 - $98,190

Investigating how RNA modifications regulate adaptive mRNA translation.

open
$868,584 - $868,584

The role of pseudouridine synthases in autophagy

open
$562,320 - $562,320

Evolution of pleiotropic consequences via mucoid phage resistance in Escherichia coli populations

open
$572,553 - $572,553

Unveiling Marine Lanthipeptides: From Biosynthesis to Antibiotic Potential Against Antimicrobial Resistant Pathogens

open
$442,710 - $442,710

Function and evolution of strains in the gut microbiota

open
$532,500 - $532,500

The Genetics of Cannabinoid Signaling: An Organismal Analysis

open
$112,000 - $112,000

Characterizing the functions of a putative DNA N6-adenine methylation demethylase AtALKBH4 in plants

open
$385,000 - $385,000

Epigenetic Regulation of Cardiac Mitochondrial Function by Long Noncoding RNA: Investigating the Impact of Ketosis and Intermittent Fasting in Heart Failure

open
$156,000 - $156,000

CTCF-mediated regulation of partial epithelial-mesenchymal transition states

open
$562,499 - $562,499

Single Molecule Glycosaminoglycan Sequencing using Lysosomal Enzymes

open
$413,036 - $413,036

Development of tools for directed evolution of high-specificity, high-efficiency recombinases

open
$408,633 - $408,633

Enabling Focused Ultrasound-Activated Gene Editing with Thermo-Controlled CRISPR-Cas9

open
$421,811 - $421,811

Ready, set, then go: Rapid posttranslational induction of protein production by drug administration in vivo

open
$192,500 - $192,500

Spatiotemporal dynamics of self-organizing protein complexes through a computational lens

open
$335,830 - $335,830

Mechanisms of Stem Cell Regulation during Tissue Renewal and Cancer Development

open
$423,890 - $423,890

Epigenetic Regulation in Human Embryonic Stem Cell Lineage Specification

open
$380,540 - $380,540

Developmental regulation of oscillatory expression

open
$2,130,924 - $2,130,924

Characterizing protein condensates and nuclear organization in genomic integrity

open
$249,000 - $249,000

Targeting Gram-Negative Bacteria for Antibacterial Strategies

open
$414,725 - $414,725

A chemical genetics approach to defining the role of iron metabolism in ferroptosis regulation

open
$150,000 - $150,000

High-throughput discovery and modeling of protein stability and dynamics

open
$540,000 - $540,000

Next-generation imaging to interrogate biological systems across time and space

open
$2,257,345 - $2,257,345

Learning biophysical principles ofcellular organization

open
$294,060 - $294,060

Computational tools for new pharmaceutical paradigms

open
$404,490 - $404,490

Sample Multiplexing as a Key Enabling Technology for Quantitative Proteomics

open
$2,527,500 - $2,527,500

Interactions of MG53 and GsdmD for Neutrophil Pyroptosis Inhibition

open
$155,463 - $155,463

CSF 5-HIAA detects secondary hypoxic insults in humans with traumatic spinal cord injuries

open
$249,000 - $249,000

Coordination of modifications across RNA species

open
$443,806 - $443,806

Molecular mechanisms of alkane hydroxylase (AlkB) reactivity and selectivity

open
$346,634 - $346,634

Molecular Mechanisms Underlying Yeast Transcription Circuit Evolution

open
$491,739 - $491,739

Impacts of copy number variation on gene regulatory networks and fitness in Candida

open
$125,000 - $125,000

Developing imaging tools to improve endolysin activity

open
$457,088 - $457,088

Catalytic Mechanism, Regulation and Drug-Target Potential of Bacterial Alarmone Hydrolases

open
$2,233,277 - $2,233,277

Learning Science Through Research-2

open
$268,538 - $268,538

Mnemonic-based digital platform for improved health literacy amount secondary students.

open
$350,000 - $350,000

Deciphering the nuclear entry mechanisms of DNA viruses

open
$381,853 - $381,853

Cherokee INSPIRE (Indigenous and Native Science Program for Igniting Research & Education)

open
$262,695 - $262,695

Vitamin B Metabolism in Host-Parasite Interactions

open
$391,364 - $391,364

Developing Novel Protein-based GABA Sensor Modules Using PLP-dependent GabR Regulators

open
$503,535 - $503,535

Transdisciplinary Predoctoral Training in Health-Integrated Technologies

open
$160,635 - $160,635

Virgin Islands Advancing Biomedical Labs with Excellence (VIABLE)

open
$569,575 - $569,575

Mechanisms of pterin-dependent regulation in proteobacterial systems

open
$446,435 - $446,435

Immunoglobulin Repertoire Analysis of Tumor Infiltrating B cells in a Metastatic HER2 Positive Breast Cancer Mouse Model

open
$170,127 - $170,127

Biochemical and biophysical elucidation of lanthanide sorting by proteins of the lanthanome

open
$75,520 - $75,520

Rapid Control and Assessment of Dissolved Gas Signals on Tissue Function andDisease.

open
$306,867 - $306,867

RNA damage induced DNA breaks: A new mechanism of genome instability

open
$854,927 - $854,927

Peptide-receptor signaling in plant-microbe interactions

open
$468,750 - $468,750

Synthetic circular supercoiled DNA: an alternative to plasmids for the production of lentiviral vectors for cell and gene therapies

open
$306,872 - $306,872

Platform for Designing and Delivering Tissue-Specific, Payload-Unrestricted, Redosable, Non-Viral Gene Therapy for Any Indication

open
$349,801 - $349,801

Developing chemical regulators of Yeats4 to engineer cell fate plasticity

open
$795,230 - $795,230

Deciphering the role of eIF5A in mitochondrial function

open
$1,345,188 - $1,345,188

An Innovative AI-Powered Wearable Physiological Sensor System for Real-Time Pain Monitoring and Management (PainVitals)

open
$349,855 - $349,855

Expression of High-Activity and High-SpecificityMicrobial L-Asparaginases from Naturally Occurring Microorganisms in the Alabama Black Belt

open
$403,640 - $403,640

Response of the commensal microbiota to host physiological stress

open
$2,095,736 - $2,095,736

Investigation of overlap between mitotic and ferroptotic pathways using novel hybrid small molecule inhibitors.

open
$559,543 - $559,543

SoS: BIO: The Anatomy of Scientific Biomedical Open-Source Software--From Code to Communities

open
$241,506 - $241,506

Molecular Biophysics of Dynamic Bacterial Nanomachines

open
$359,179 - $359,179

Enantioselective Chemical Synthesis Methods Using Lewis Base and Transition Metal Catalysis

open
$631,989 - $631,989

Fluorescent Probes that Span the Spectrum for Multi-Color Imaging of Peroxynitrite in Living Cells

open
$540,053 - $540,053

Chemical Engineering of Extracellular Vesicles for Enhanced Glioblastoma Therapy: Undergraduate Biomedical Research at Southern Utah University

open
$155,695 - $155,695

Innovative drug design technologies from computational mapping of energy, entropy, and free energy in proteins and protein-ligand systems

open
$638,334 - $638,334

Frontiers in measuring and simulating molecular structures and processes.

open
$361,283 - $361,283

Sigma-regulator recognition and activation of regulated intramembrane proteolysis by a site-1 protease during iron import cell surface signaling in Gram-negative bacteria.

open
$543,750 - $543,750

Decoding the Molecular Choreography of Diverse Vesicle Release Mechanisms

open
$2,313,209 - $2,313,209

Bridging the Gap Between Prediction and Reality in Structural Biology

open
$501,000 - $501,000

Aptamer-based biosensing probes for chemical imaging of multiple analytes at single cells

open
$378,715 - $378,715

Tools to reveal the dynamics of molecular forces in living cells

open
$317,089 - $317,089

Development of a Targetable Transposase Platform for Precision Gene Integration in Human Cells

open
$522,764 - $522,764

Synthesis and Pharmacological Evaluation of 5-Hydroxy-2-(2- phenylethyll)chromone Analogues

open
$384,609 - $384,609

Mapping 3D-genome motion with next generation tracking technology to distinguish molecular drivers of cis-regulatory control

open
$462,119 - $462,119

Cobalamin serves as a key redox-active mediator, protecting Porphyromonas gingivalis from oxidative stress.

open
$273,875 - $273,875

Navajo NARCH - Research Infrastructure Enhancement Project

open
$251,055 - $251,055

Coding and Noncoding Molecular Mechanisms of a Bifunctional Gene in Multiple Cellular Contexts

open
$435,875 - $435,875

Investigate the mechanism lamins regulate genome organization and gene expression during development

open
$335,000 - $335,000

Conserved and Unique Features Regulating Meiotic Crossover Formation

open
$919,914 - $919,914

Algorithms and Software for Biomolecular Structure Determination at the Proteome Scale

open
$1,476,000 - $1,476,000

Mechanisms of Left Right Organizer Development

open
$2,055,625 - $2,055,625

A Spatial and Temporal Analysis of MCH Signaling in the Developing Adipocyte

open
$442,397 - $442,397

Development of an intelligent droplet acoustofluidic platform for automated liquid-liquid handing and monitoring in biomedical research

open
$370,783 - $370,783

Variation, regulation, and conservation of metabolic signaling across hibernating mammals

open
$300,721 - $300,721

Fundamental properties of circadian rhythms

open
$380,089 - $380,089

Training a new generation of biologists in quantitative bioimaging with Microtutor

open
$540,000 - $540,000

Development of a nuclear alpha-ketoglutarate biosensor system to study metabolic control of the epigenome

open
$1,792,800 - $1,792,800

Mechanism of a hypothiocyanous acid reductase

open
$558,493 - $558,493

The Characterization of RNA Binding Motif Protein 48 (RBM48) in U12 Intron Splicing, Cellular Differentiation, and Development

open
$562,500 - $562,500

Student Career Enhancement Program

open
$244,949 - $244,949

The genetic basis of complex traits: from yeast to humans

open
$2,117,247 - $2,117,247

Topical nitrite reverses nitroglycerin tolerance.

open
$306,728 - $306,728

REMIT (Rescue Mitochondrial Therapeutics): Unlocking Broad-Spectrum Mitochondrial Rescuers

open
$1,016,229 - $1,016,229

Chemical Specific Measurements of Cellular Heterogeneity in Organoids

open
$416,726 - $416,726

From protein structures to effective drugs via machine learning and molecular simulation

open
$590,806 - $590,806

Novel Methods for Nicotinic Receptor Modulation in the Treatment of Post-Operative Pain

open
$349,999 - $349,999

VITaLS: Visual Thinking and Learning Strategies: Enhancing Health Professions Education through Virtual Reality Enabled Art Museum Experiences

open
$261,620 - $261,620

Investigating the safety and efficacy of pillararene sulfates as novel and effective reversal agents for both steroidal and non-steroidal neuromuscular blocking agents.

open
$368,367 - $368,367

A novel spatial biology platform for protein profiling which is cost effective and scalable

open
$306,700 - $306,700

Multiscale Simulation of Key Biomolecular Processes in the Cell

open
$1,970,835 - $1,970,835

Development of small molecule inhibitors of the E3 ligase NEDD4

open
$75,520 - $75,520

Target-Specific Dyes with Responsive Long-Lived Fluorescence Lifetimes for Biological Interrogation

open
$382,026 - $382,026

Statistical methods to delineate the spatial and temporal pattern of cell-cell interactions in Spatial Transcriptomics data

open
$449,625 - $449,625

Mapping and Prediction of Epistatic Enhancer Interactions in Gene Regulation

open
$484,000 - $484,000

Decoding the Neural Foundations of Sexual Dimorphisms in Aggression: A Female-Centric Approach

open
$2,050,000 - $2,050,000

Development of a continuous microbial fermentation system using reduced genome E. coli that undergo programmed autolysis and generate nuclease post-production for the manufacture of biopharmaceuticals

open
$937,537 - $937,537

Mechanistic studies of ABC importers in pathogenic bacteria

open
$498,778 - $498,778

Integrating Machine Learning and Atomistic Simulations for Accurate Prediction of Drug Molecular Crystal Solubility

open
$401,250 - $401,250

Sepsis diagnosis using chemically modified DNA aptamers

open
$356,500 - $356,500

Achieving ultra-high-density, ultra-high-precision single molecule localization microscopy with whole-video deep learning architectures

open
$349,280 - $349,280

Elucidating the epigenetic regulation of extracellular matrix and virus-induced fibroblast activation

open
$249,000 - $249,000

Imaging macromolecular machines in gene regulation

open
$385,065 - $385,065

Robust high-throughput superresolution imaging with speckle illumination

open
$1,926,960 - $1,926,960

Approaches to heterocyclic rich anti-microbial natural products

open
$528,595 - $528,595

Computational approaches for elucidating proteomes and interactomes

open
$1,968,575 - $1,968,575

Generative multiscale models of biomolecular conformational dynamics: from fluctuations to many-component assemblies

open
$410,256 - $410,256

Molecular genetic dissection of tube morphogenesis in the Drosophila tracheal system

open
$2,250,542 - $2,250,542

Mechanobiology of the Nucleus

open
$21,500 - $21,500

Project MATCH: Multi-spectral AI/ML powered Burn and Wound Evaluation Technology using a Cost-Effective Handheld Device.

open
$349,910 - $349,910

Investigating the mechanisms driving host-associated microbial community dynamics

open
$388,750 - $388,750

BBB and neurovascular function modulation by endothelial NOX1 in Alzheimer's Disease

open
$219,000 - $219,000

Early Life Adversity and Adult Substance Misuse: The Moderating Role of Residential Characteristics

open
$196,967 - $196,967

Defining the Rules for Pioneer Factor Nucleosome Engagement

open
$2,203,340 - $2,203,340

Investigating molecular mechanisms of endocytosis of the activated B cell receptor in health and disease

open
$249,000 - $249,000

Investigating the role of RNA helicase DHX36 in modulating aberrant RNA condensation

open
$86,930 - $86,930

MEDIC-MicroED Imaging Center at UCLA

open
$1,341,283 - $1,341,283

A concise dearomative approach to the synthesis of quinolizidine natural products

open
$74,632 - $74,632

Structural investigations into the regulatory states of human Ribonucleotide Reductase

open
$74,632 - $74,632

Light-Driven Deracemization of Atropisomers Enabled by Chiral Photocatalysts

open
$74,632 - $74,632

Chromatin state contributions to cytoplasmic incompatibility

open
$78,040 - $78,040

Exploring the Impact of Membrane Environments on Particulate Methane Monooxygenase

open
$75,052 - $75,052

Use of de novo Protein Design Methods to Rationally Redesign P450 Enzymes for New Cofactors and Substrates

open
$75,052 - $75,052

Modular Synthesis of Saturated, Nitrogen-Containing Heterocycles Guided by Mechanism-Aware Machine Learning Models

open
$75,520 - $75,520

The role of microtubule allostery and mimicry in the regulation of tubulin post-translational modifications

open
$640,500 - $640,500

Advancing Probe Technology for Ultrasensitive RNA Imaging via Hybridization Chain Reaction

open
$306,788 - $306,788

Determining the Role of csoS2 in Carboxysome Assembly and Regulation

open
$75,052 - $75,052

Mechanisms of Low-Intensity Focused Ultrasound Neuromodulation for Post-Traumatic Stress Disorder in Frontline Healthcare Workers

open
$431,302 - $431,302

Defining the Roles of Biotransformation in Arsenic-Induced Hematotoxicity

open
$259,250 - $259,250

Deracemization of Beta2- and Gamma2-amino acids

open
$75,052 - $75,052

Site-Selective C-H Borylation Directed by Noncovalent Interactions

open
$74,632 - $74,632

Newt iris to lens reprogramming as a model to study eye tissue regeneration in vertebrates

open
$189,459 - $189,459

Cellular Basis of Novel Organelle Integration by a Photosynthetic Animal

open
$77,332 - $77,332

Mapping the sequence-function landscape of a small reactive protein in ultra-high-throughput

open
$75,052 - $75,052

Investigation of Molecular Cues Driving IHC vs. OHC Differentiation Using an Insm1 Knockout Mouse Model

open
$291,000 - $291,000

Mechanical Anisotropy in E-cadherin-Induced Polarized Actin Architecture as a Driver of Interfacial Opening and Adherens Junction Formation Between Cells

open
$79,120 - $79,120

Molecular mechanism of polyamines on DNA dynamics during DNA repair

open
$77,752 - $77,752

Critical Care Training Program

open
$3,000 - $3,000

Improving utilization of guideline directed medical therapy and structured exercise interventions in individuals with intermittent claudication in a rural setting

open
$132,000 - $132,000

De novo design of artificial haloperoxidase enzymes

open
$75,052 - $75,052

The role of protein phase separation in the circadian clock

open
$75,520 - $75,520

High-throughput, bond-specific 3D chemical microscopy for lipid metabolism in cancer metastasis

open
$155,484 - $155,484

In-cell analysis and elaboration of RNA-targeting fragment ligands

open
$75,052 - $75,052

Investigation of the mechanistic role of TLKs in Nucleotide Excision Repair

open
$282,454 - $282,454

Growing Healthy Children and Families in Rural Arkansas

open
$132,469 - $132,469

Applying a just-in-time adaptive intervention framework to understand and treat dynamic, symptom-maintaining stress among individuals with comorbid obesity and pain

open
$223,500 - $223,500

Gastrointestinal Insights into Anorexia Nervosa Treatment

open
$291,040 - $291,040

Role of host glutaminolysis in tuberculosis pathogenesis

open
$196,875 - $196,875

Investigation Into the Progression of MASLD to MASH and HCC

open
$110,244 - $110,244

Leveraging Ecological Interactions to Unearth Cryptic Metabolites and Regulatory Pathways from Algal and Plant Microbiomes

open
$137,484 - $137,484

Interplay Between Transcription and ATP-dependent Chromatin Remodeling for Genome Regulation

open
$280,905 - $280,905

Enantioselective Hydrochlorination of Alkenes enabled by Cooperative Catalysis and Enantioconvergent Dynamic Kinetic Resolution of Quaternary Stereocenters

open
$125,000 - $125,000

The Role of Interleukin-1Beta- Fibrin(ogen) Interaction in Sepsis-Induced Coagulopathy.

open
$181,440 - $181,440

Influences of developmental metabolic flux on physicochemical properties of the nucleus

open
$125,000 - $125,000

Dynamic Modeling of Dicer Function

open
$75,520 - $75,520

Interrogating the Role of Chromatin in Nuclear Receptor Structure and Function

open
$122,763 - $122,763

Role of vascular permeability in the pathogenesis of osteoarthritis

open
$310,198 - $310,198

Hit to lead development of imidazopyridine containing compounds as treatment for babesiosis

open
$191,875 - $191,875

Dynamic interplay between genome organization and long noncoding RNAs in the regulation of gene expression

open
$446,876 - $446,876

Elucidating Biomolecular Dynamics using Magnetic Resonance Augmented by Machine Learning and Quantum Technologies

open
$142,182 - $142,182

Regeneration of lymphatic valve after injury

open
$160,566 - $160,566

Function of maternal mRNA during zebrafishembryogenesis

open
$429,000 - $429,000

Dissecting a Novel Pathway for Degradative Endosome Generation during Rapid Synaptic Vesicle Recycling Pathway

open
$462,500 - $462,500

In vivo platforms for exploring co-evolution of ligands, receptors, and their targets

open
$423,734 - $423,734

Investigating the Role of CircRNAs in Pain and Nocieptive Sensitization

open
$175,589 - $175,589

Visualization of native chromatin-associated complexes to elucidate chromatin regulatory mechanisms

open
$484,000 - $484,000

Mechanisms of translation response to stress

open
$457,875 - $457,875

COMPOSITION-DEPENDENT CONTROL OF NUCLEOLI AND NUCLEOLAR-DERIVED CONDENSATES

open
$440,000 - $440,000

Mechanisms Regulating the Kinetics and Specificity of Nuclear-Cytoplasmic Transport

open
$431,750 - $431,750

Mechanism and Function of XIST in X Chromosome Inactivation Maintenance

open
$456,500 - $456,500

Development and Connectivity of the Circadian Clock Neuron Network

open
$415,822 - $415,822

Development of Self-Assembling Pyrrole-Imidazole Polyamides for the Treatment of Friedreich’s Ataxia and Prostate Cancer Using Proximity-Induced Bioorthogonal Chemistry

open
$75,880 - $75,880

Bacterial Regulation of Acid Resistance and Amino Acid Metabolism

open
$532,909 - $532,909

Uncovering Morphogenetic Modularity with Data Science

open
$400,881 - $400,881

Indigenous Determinants of Prenatal Substance Use

open
$102,369 - $102,369

Multi-glycomic characterization of cell membrane and the role of glycans in protein-protein interactions

open
$402,051 - $402,051

Molecular Mechanisms of Antimicrobial Resistance from Machine Learning Augmented Enhanced Sampling

open
$401,285 - $401,285

The multifaceted pathways of astrovirus entry and egress

open
$422,677 - $422,677

Mechanisms of SWI/SNF complex chromatin targeting selectivity

open
$1,317,220 - $1,317,220

Deconvoluting disparate roles of DDX6 in translational control

open
$76,300 - $76,300

Evolution-based understanding and design of proteins

open
$487,525 - $487,525

New ionization source technology for single-cell multi-omics

open
$408,375 - $408,375

Genomics-Accelerated Discovery and Biosynthesis of Phosphonic Acid Natural Products

open
$410,893 - $410,893

Origin and Diversification of Gene-by-Environment Interactions

open
$423,195 - $423,195

Defining the PS neighborhood proteins on apoptotic cells and their impact on efferocytosis

open
$388,750 - $388,750

Structural determination of TrkB assembly and activation

open
$76,300 - $76,300

Statistical methods to link genetic variants to regulatory landscapes

open
$451,000 - $451,000

DIRECTED EVOLUTION OF BIOCATALYSTS FOR ASYMMETRIC HYDROGEN ATOM TRANSFER REACTIONS

open
$420,981 - $420,981

Specialized adaptations in the model alpha-proteobacterium Sinorhizobium meliloti

open
$422,314 - $422,314

Molecular and Metabolic Adaptations of Intracellular Parasitism

open
$423,500 - $423,500

Elucidating the Biological Roles Of tRNA Modification Enzymes

open
$578,733 - $578,733

Ruthenium-Catalyzed Enantioselective and Site-selective Functionalization of Carbon-Hydrogen Bonds and Their Applications in Target Synthesis

open
$548,084 - $548,084

Predictable molecular evolution during adaptation

open
$431,750 - $431,750

Phosphatidylinositol 4-phosphate at the Golgi complex: novel roles in regulating plasma membrane lipid composition and organization.

open
$554,528 - $554,528

Defining Centriolar Plaque Architecture and Function Across Eukaryotic Diversity Using Expansion Microscopy and Proteomics

open
$396,250 - $396,250

Structure and Relations of Proteins and Nucleic Acids

open
$403,836 - $403,836

Non-Invasive Single-Cell Morphometry and Tracking in Living Bacterial Biofilms

open
$425,145 - $425,145

Post-Transcriptional Regulation of Tissue Regeneration by RNP-Granules

open
$406,667 - $406,667

Regulation of Nucleocytoplasmic Compartmentalization

open
$456,500 - $456,500

Astrocyte Lipometabolic Regulation by Acyl-CoA Binding Protein as a Neurobiological Target Underlying Central Metabolic Dysfunction in Alzheimer's Disease

open
$260,873 - $260,873

Mechanisms of Genome Integrity Maintenance: Break-Induced Replication at Repetitive DNA Sequences

open
$444,125 - $444,125

Regulation of cell fate specification to regenerate complex sensory organs

open
$393,008 - $393,008

Mechanisms of Lytic Granules Exocytosis

open
$567,411 - $567,411

Correlated factor models for exploratory analysis of complex multimodal study designs

open
$406,250 - $406,250

Molecular insights into regulator-dependent transcription initiation pathways

open
$76,780 - $76,780

Sex differences in regulation of innate immune response by neurotransmitters

open
$383,750 - $383,750

Mechanisms of Action of Gene-Regulatory RNA Molecules

open
$427,227 - $427,227

Methods for quantifying selection and predicting evolutionary dynamics

open
$417,620 - $417,620

Advancing statistical genetics tools for reliable drug target discovery and treatment optimization

open
$414,305 - $414,305

Harnessing Steroidal Molecules of Plants

open
$425,974 - $425,974

Bacterial stress responses mediated by c-di-AMP

open
$412,433 - $412,433

Polysaccharide utilization and antimicrobial resistance in abundant gut bacteria

open
$434,169 - $434,169

Immunometabolic Regulation of CD8 T Cell Dynamics in Human Critical Illness and Sepsis

open
$186,224 - $186,224

The Molecular Basis of Transcription-Replication Conflicts and Pathways to Resolution

open
$125,000 - $125,000

Cellular and molecular mechanisms of stem and progenitor cell development during homeostasis and after injury

open
$425,333 - $425,333

Novel strategies to expand the chemical diversity of phage display libraries for inhibitor discovery

open
$383,880 - $383,880

Selective N-alkylation of azoles via anion-binding catalysis

open
$76,300 - $76,300

K+ channel structural dynamics landscape: from selectivity to gating

open
$249,000 - $249,000

Metalloenzyme Discovery and Pathway Engineering to Functionalizethe Inert C-H bonds of Amino Acids

open
$75,520 - $75,520

De novo design of allosterically regulated proteins to study intramolecular signal transduction

open
$75,052 - $75,052

Decoding cellular history in longitudinally inaccessible tissues

open
$380,371 - $380,371

Transcription regulation of recovery from stress

open
$565,800 - $565,800

Inter-Organelle UPR Coordination and Cellular Proteostasis

open
$390,000 - $390,000

Decoding the interplay between QKI and m7G methylation on 3'UTR

open
$506,000 - $506,000

Mechanisms in the mammalian circadian clock

open
$1,872,048 - $1,872,048

Mechanisms Regulating Zygotic Genome Activation

open
$460,771 - $460,771

Development and Application of Nicotinic Acetylcholine Receptor Targeted Peptides for Biomedical Research

open
$500,500 - $500,500

Myosin structure and function in health and disease

open
$494,796 - $494,796

Mechanisms of Dynamic Cytoskeleton and Membrane Interactions

open
$613,838 - $613,838

Subcellular transport, regulation, and function of RNAs during early development

open
$460,953 - $460,953

The repeated evolution of hybrid melanoma across Xiphophorus fish

open
$76,780 - $76,780

Molecular Mechanisms of Chromatin Remodeling and Deacetylation

open
$425,667 - $425,667

Defining the dynamics of eukaryotic translation and mRNA decay

open
$286,729 - $286,729

Molecular mechanisms underlying functional evolution of bioluminescent proteins from haloalkane dehalogenases

open
$75,052 - $75,052

Mechanistic insights into the initiation of DNA replication in human cells

open
$434,212 - $434,212

New Selective Reactions of Carbocations

open
$446,219 - $446,219

Enabling mass spectrometry-based mid-down sequencing of large modified RNAs

open
$607,470 - $607,470

Coordination of germline chromatin organization mechanisms to initiate embryogenesis

open
$537,696 - $537,696

Reconstructing Evolutionary Arms Races

open
$1,601,098 - $1,601,098

Harnessing XNAs to Expand the Genetic Toolkit for RNA Silencing and RNA editing

open
$406,250 - $406,250

Probe translation regulation by imaging single protein-mRNA interaction in live cells

open
$426,250 - $426,250

A comprehensive analytical framework for multi-source, multi-way, and multi-cohort data

open
$333,290 - $333,290

Compartmentalization and discrimination of dsRNA in the nucleus

open
$506,550 - $506,550

Integrating dynamic cell behaviors to drive cranial morphogenesis

open
$412,373 - $412,373

Investigating how splicing factor homeostasis shapes transcriptomes in pluripotency and differentiation

open
$46,991 - $46,991

Cellular Therapy for Sepsis and Lung Injury

open
$445,983 - $445,983

Cell Fusion and Gene Expression in the C. elegans Epidermis

open
$123,687 - $123,687

Pioneering Mass Spectrometry-Based Footprinting to Reveal Human Membrane Protein Structures in Native Membranes and Tissues

open
$406,112 - $406,112

Reprogramming cells for repair of chronic wounds

open
$409,941 - $409,941

Advancing targeted delivery of intracellular protein therapeutics

open
$449,625 - $449,625

Mechanisms that regulate cellular responses to phosphate

open
$429,000 - $429,000

Investigating brain-body allostasis via longitudinal in vivo imaging

open
$407,603 - $407,603

Deciphering the regulatory mechanisms of extracellular particle-mediated signaling

open
$432,569 - $432,569

Biophysical theory for condensate dynamics: advancing beyond minimal models

open
$406,026 - $406,026

Mapping the Mechanome: A Systems-level Understanding of Mechanical Mediators and Pathways

open
$433,125 - $433,125

Dissecting the molecular mechanisms of membrane protein complex assembly

open
$423,500 - $423,500

Integrated mass spectrometry strategies to decipher metabolite-protein cross regulation

open
$434,000 - $434,000

Molecular determinants of voltage-gated ion channels' localization and function

open
$446,875 - $446,875

Regulation of ER-phagy during cellular stresses

open
$429,000 - $429,000

Modules to improve the quality of the mentor-mentee working relationship

open
$94,154 - $94,154

Data-driven modeling of molecular mechanisms underlying cellular quiescence

open
$421,737 - $421,737

Breath Biomarkers of Disease and Health Outcomes (BREATHE OUT)

open
$225,000 - $225,000

Molecular Timekeepers: Converging Pathways in Circadian Control

open
$487,287 - $487,287

Examining the processes that deform bacterial membranes to initiate cell division

open
$1,600,449 - $1,600,449

Responsive and Targeted Modulation of Reactive Sulfur Species

open
$398,464 - $398,464

Functions and mechanisms of metalloenzymes in natural product and cofactor biosynthesis

open
$737,152 - $737,152

Site-specific Non-LTR Retrotransposon Mechanisms of Mobility and Transgene Insertion

open
$617,574 - $617,574

PULSE (Program Understanding and Learning through Strategic Evaluation)

open
$105,987 - $105,987

Role of CTCF in Nucleotide Excision Repair

open
$300,872 - $300,872

Evolving together, evolving apart: probing the genomic basis of a facultative host-microbe mutualism

open
$393,250 - $393,250

Oligosaccharide cross-feeding and competition in microbial communities

open
$375,898 - $375,898

Correlative and multimodal molecular imaging of biological tissues with high sensitivity and cellular spatial resolution

open
$303,804 - $303,804

Regulatory Roles of Noncoding RNAs in Gene Expression and Cellular Stress Responses

open
$440,000 - $440,000

Novel role of PAQR4 in Pancreatic Beta Cell Function and Type 2 Diabetes

open
$269,500 - $269,500

Wabanaki TURTLE

open
$463,435 - $463,435

Nitrogenase - From mechanistic investigation to heterologous expression

open
$503,280 - $503,280

Peroxiredoxin Biochemistry and Redox Regulation in Metabolic Stress and Signaling

open
$432,844 - $432,844

Mechanism, regulation and impact of transposon activation

open
$523,255 - $523,255

Exploring Tissue-Specific Mechanisms and Requirements for Nucleolin Organization in Vivo

open
$464,750 - $464,750

Next-generation proximity labeling enzymes for mapping spatial proteomes in living cells

open
$616,000 - $616,000

Uncovering the fundamental principles of transcriptional regulation

open
$460,625 - $460,625

Nitrogenase - Where Haber-Bosch meets Fischer-Tropsch

open
$487,953 - $487,953

Designing cell-instructive viscoelastic hydrogels to understand and exploit mechanobiology

open
$415,171 - $415,171

Developing Selective-Dissociation for Proteoform Characterization in Top-Down Proteomics

open
$396,886 - $396,886

BRE-SPAD at Western Washington University

open
$599,232 - $599,232

Integrating imaging and multi-omics data to infer single-cell 3D genome structures

open
$363,570 - $363,570

BRE-SPAD at Meharry

open
$684,131 - $684,131

Development of polarizable Gaussian multipole force field for biomolecular simulations based on in-solution electrostatics

open
$341,970 - $341,970

Advancing Statistical Methods for Next-Generation Microbiome Data Analytics

open
$433,985 - $433,985

Inline impedance-activated recognition, tracking and sorting system on single-cell biophysical metrics

open
$1,092,610 - $1,092,610

BRE-SPAD at the University of Minnesota Duluth

open
$759,572 - $759,572

Harnessing the human myeloid system to improve surgical recovery

open
$431,200 - $431,200

CHARACTERIZING FLAGELLAR MOTILITY IN THE CONTEXT OF HOST-MICROBE SYMBIOSIS

open
$388,333 - $388,333

Cell dormancy and virus entrapment

open
$428,857 - $428,857

Social regulation of oxidative stress in the brain

open
$304,250 - $304,250

Robust and Scalable Machine Learning and Statistical Methods for Genomics

open
$510,183 - $510,183

Structure-Function Studies of Apolipoprotein B100

open
$429,797 - $429,797

Generalizable quantitative analysis of cell spheroid models and tissues using a single electrochemical platform with custom pneumatic and microfluidic circuits

open
$417,061 - $417,061

Investigating Dead Cell-Phagocyte Interaction at the Phagosomal Interface to Decode Death-Associated Responses

open
$423,352 - $423,352

BRE-SPAD at Auburn University at Montgomery

open
$554,945 - $554,945

Mechanobiological regulations of collective cell movement: insights from in vivo to in vitro

open
$412,124 - $412,124

Bioelectrical Regulation of Innate Immunity in Pancreatic Cancer Cells

open
$78,612 - $78,612

Interaction between c-di-GMP and cAMP signaling in Pseudomonas aeruginosa biofilms

open
$125,000 - $125,000

Evolution and mechanisms of pathogen avoidance

open
$125,000 - $125,000

Revealing Cellular Determinants of LINE-1 Retrotransposition Outcomes

open
$109,448 - $109,448

Intermolecular RNA-RNA interactions in stress granule regulation and disease

open
$125,000 - $125,000

Induced-Proximity Platform to Control Cellular Signaling and Proteostasis

open
$118,242 - $118,242

Developing a Nanopore Tweezer Toolkit for Analyzing Kinase Structural Dynamics and Screening Allosteric Inhibitors

open
$396,854 - $396,854

Unlocking New Chemistries in Extant Enzymes for Synthesizing Bioactive Molecules

open
$249,000 - $249,000

Enzyme Recruitment in Metabolic Plasticity and Evolvability

open
$616,401 - $616,401

Organic Pseudometals to Sustain and Transform Small-Molecule Drug Synthesis

open
$1,516,500 - $1,516,500

Thermodynamic and Functional Analysis of Consensus and Covariance in Proteins, and Bivalent Notch Complexes

open
$65,963 - $65,963

Global control of co-transcriptional splicing

open
$542,363 - $542,363

Function, evolution and engineering of proteins

open
$361,952 - $361,952

Hormonal control of stem cells in the Drosophila ovary

open
$473,955 - $473,955

Chromosome-specific meiotic biology

open
$160,613 - $160,613

Mechanistic Investigations on Anchored Substrates and Inhibitors for Carrier Protein Dependent Acyl-Homoserine Lactone Synthases.

open
$348,963 - $348,963

Function and Regulation of Lysine Methylation Dependent Proteolysis

open
$679,856 - $679,856

Mechanics of Convective Cell Motion

open
$669,737 - $669,737

Understanding Cell Behavior in Precise Multifunctional Biomimetic Matrices Prepared via 3D Printing

open
$385,671 - $385,671

Molecular basis for CRISPR-associated transposons and RNA-guided transcriptional regulation

open
$501,917 - $501,917

Decoding the role of entropy in protein structural stability, dynamics, and function in health and disease

open
$583,420 - $583,420

DMS/NIGMS 1: Bacterial dispersal and nutrient transport on fungal highways

open
$194,292 - $194,292

The Logic of Aptamer Isolation

open
$654,950 - $654,950

The role of the ribosome and translation factors in mediating stress signaling

open
$2,777,852 - $2,777,852

High Throughput Lipidomic Profiling with High Structural Specificity for Phenotypic Screening

open
$465,197 - $465,197

The synthesis and trafficking of phosphatidylserine in cellular cholesterol homeostasis.

open
$335,400 - $335,400

Tools for measuring post-translational modification enzyme activity in vitro and in cells

open
$188,627 - $188,627

Computational and Data Science Approaches to Enhance Biomolecular NMR

open
$457,875 - $457,875

Structure/Function of Potential Human Cytochrome P450 Drug Targets

open
$620,934 - $620,934

Molecular Basis for the TREX-2 mRNA Nuclear Export Pathway

open
$758,594 - $758,594

DMS/NIGMS 2: Bayesian modeling of single cell spatial transcriptomics data to identify significant spatial

open
$392,812 - $392,812

Biomedical Technology Optimization and Dissemination Center (BTOD)

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Grants952
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