Funding Organization
National Cancer Institute
1000 opportunities
About
No description available for this funder.
Grants (1000)
REWIRE-CAN - Rewiring Cancer with Novel Signalling Therapies
open$1,710,054 - $1,710,054
Harnessing Molecular Imaging for the Delineation of Sessile Serrated Adenomas
open$35,814 - $35,814
Integration of Life Expectancy Estimates into Electronic Health Record Decision Support for Men with Prostate Cancer
open$574,557 - $574,557
Targeted degradation of glycoimmune checkpoints Siglec-7 and -9 for cancer immunotherapy
open$748,410 - $748,410
Reprogramming Virus-Primed Immunity for Targeted Immunotherapy of Ovarian Cancer
open$696,221 - $696,221
Lineage plasticity sensitizes FGFR3-mutant bladder cancer to FGFR inhibitors
open$637,473 - $637,473
Mechanisms and Functional Roles of PARP1 Hyperactivation in Cancer
open$639,707 - $639,707
Alliance for Clinical Trials in Oncology Clinical Trials Core
open$83,516 - $83,516
Dynamics and Encoding in Cell Signaling
open$18,000 - $18,000
Local Delivery of Chemotherapy to Aggressive Meningiomas using a Bioresorbable Implant
open$620,671 - $620,671
Establishing the University of Arizona Cancer Center as a Lead Academic Participating Site in the National Clinical Trials Network
open$310,412 - $310,412
Modeling bone metastasis and tumor dormancy in prostate cancer
open$820,855 - $820,855
Immune checkpoint receptors and their blockade in skin and gut
open$602,641 - $602,641
Neuropeptide Y Receptor Signaling in Gut GVHD: Targeting Y1/Y2 Pathways for Immune Modulation
open$164,500 - $164,500
Incretin Mimetics for Intercepting Obesity-Related Cancers: Effects and Underlying Mechanisms
open$656,285 - $656,285
Integrating High Resolution Elemental Mapping with Spatial Transcriptomics to Analyze Metal Based Pathttps://apps.era.nih.gov/gmii/manage/view.era?applId=11296190#hways in Tumor Growth and Spread
open$743,264 - $743,264
Tumor-targeted delivery of tetanus toxoid by Listeria reduces glioblastomas in mice
open$431,970 - $431,970
Lactic acid sensing is a targetable vulnerability in clear cell Renal Cell Carcinoma
open$529,260 - $529,260
The Johns Hopkins Translational Science Team and Consortium for ETCTN Studies
open$1,854,447 - $1,854,447
Social Health, Activity Behaviors, and Quality of Life among Young Adult Cancer Survivors: A longitudinal Study
open$562,830 - $562,830
WP2 - Define and Synthesize
open$839,584 - $839,584
A Registry-Based Study of Patterns of Use of Targeted Therapies for Metastatic Cancers in Diverse Populations
open$334,735 - $334,735
Population Health Management Approaches to Increase Lung Cancer Screening in Community Health Centers
open$1,154,997 - $1,154,997
Reprograming CAR T cells by targeting IKZF-HDAC mediated chromatin remodeling to treat breast cancer
open$45,669 - $45,669
Investigating the influence of phospholipases onimmune evasion
open$50,114 - $50,114
Engineering Chimeric Ligand Presenting T Cells (CLiP-Ts) Targeting Receptors of Extranodal NK/T-Cell Lymphoma: A Comparative Study with Traditional CAR-T Cell Therapy
open$55,114 - $55,114
Exploring CLK2 as a novel therapeutic target in rhabdomyosarcoma
open$475,681 - $475,681
The evolutionary landscape of BRCA-associated breast cancer and its impact on endocrine therapy resistance
open$246,362 - $246,362
Imaging and Spectroscopy of Radiation Chemistry in FLASH Radiotherapy to Inform Clinical Translation
open$369,394 - $369,394
Role of ZC3H15 in Pancreatic Cancer Pathogenesis and Therapeutic Response
open$407,726 - $407,726
Evaluating the Impact of AI on Breast Cancer Screening Quality and Effectiveness: A Prospective RCT
open$761,691 - $761,691
Fatty Acid Synthase Driven Exosome Secretion in Colorectal Cancer Metastasis
open$154,000 - $154,000
Integrin alpha-6 drives metabolic adaptation and breast cancer survival in leptomeningeal metastasis
open$626,475 - $626,475
Reactivation of Prostate Cancer Proliferation from Dormancy by Osteoclastic Tunneling Nanotubes
open$433,759 - $433,759
Fit2ThriveMB: Optimization of a Physical Activity Promotion Intervention for Metastatic Breast Cancer Patients
open$663,998 - $663,998
Real-time response prediction to GBM CART cell therapy with patient-matched organoids
open$668,864 - $668,864
Studying the Utility of Deep Learning Derived MRI Imaging Biomarkers for Localized Prostate Cancer
open$519,592 - $519,592
Tracking Residential Air Quality to Quit Smoking
open$649,603 - $649,603
MBD4 Driven AR Reprogramming and Luminal Lineage Specification in Prostate Cancer
open$151,618 - $151,618
Mechansim of RING-between-RING ubiquitin signaling in DNA repair
open$482,637 - $482,637
AURKA/KAP1 signaling in breast cancer metastasis
open$443,359 - $443,359
Metabolomic mechanisms contributing to prostate cancer risk across multiple populations
open$760,396 - $760,396
I3-BC: Image-Based Infiltrating Immune Cell Detection and Outcomes in Breast Cancer Clinical Trials
open$394,695 - $394,695
Lost in Translation: Inhibiting eIF4A to Treat AML
open$409,463 - $409,463
Dissecting the non-mutational mechanisms of benign-to-malignant transition in colon cancer
open$704,182 - $704,182
Targeted Prodrug Cytokines for Metastatic Breast Cancer Immunotherapy
open$384,524 - $384,524
Impact of exogenous hormones on Prostate Cancer Risk, Detection, and Outcomes in the Nationwide Veterans Affairs Health System
open$646,784 - $646,784
Short-wave infrared Cerenkov imaging to better visualize targeted radiotherapy and diagnostic radiotracers
open$644,423 - $644,423
Improved Surgical Visibility and Navigation during Endoscopic Treatment of Upper Tract Urothelial Carcinoma
open$603,714 - $603,714
Multimodal computational models for early prediction of peritoneal recurrence in gastric cancer
open$513,915 - $513,915
Communication and Hospice Online with Optimal Support and Engagement (CHOOSE)
open$656,181 - $656,181
Leveraging First Mouse Model Reproducing Human Translocation Renal Cell Carcinoma to Investigate Molecular Mechanisms
open$596,501 - $596,501
Causal mechanisms driving germline predisposition to myeloproliferative disorders
open$561,407 - $561,407
Weak Cell Adhesion is a Prognostic Signature of Invasive Cancer
open$486,094 - $486,094
Targeting VIP–VPAC Signaling to Reverse Immune Exclusion and Enhance Immunotherapy Response in Pancreatic Cancer
open$636,358 - $636,358
Utilizing integrin-targeted PET imaging and therapeutics to predict and treat radiation-induced pulmonary fibrosis
open$645,414 - $645,414
Targeting disulfidptosis in cancer: mechanisms and preclinical translation
open$621,632 - $621,632
Elasticity imaging of breast cancer during treatment
open$594,297 - $594,297
Overcoming the blood-brain barrier with nanoparticle vaccines against gliomas
open$767,498 - $767,498
Detecting DICER1: A global partnership to cure pediatric lung cancer
open$432,405 - $432,405
CAUSE - Connecting DNA Adducts, Unexplained Mutational Signatures, and Cancer Etiologies
open$1,143,033 - $1,143,033
Molecular mechanisms and pharmacological modulation of Multidrug Resistance Protein 1 (MRP1)
open$50,114 - $50,114
Elucidating the functional limitations of cDC1 in Glioblastoma to inform immunotherapeutic strategies.
open$39,692 - $39,692
Fate Determinants of Basal-Squamous Pancreas Cancer
open$50,114 - $50,114
Development of novel RPS23 inhibitors for the treatment of leukemia
open$688,012 - $688,012
2026 Chromatin Structure and Function Gordon Research Conference and Gordon Research Seminar
open$12,000 - $12,000
Microbubble augmentation of immunotherapy in head and neck cancer
open$401,115 - $401,115
Spatial control of synthetic immunogenic cytotoxicity for the treatment of locally advanced lung cancer
open$682,140 - $682,140
Protein O' Mannosylation as a therapeutic vulnerability in KIAA1549-BRAF-driven pediatric low-grade glioma
open$721,653 - $721,653
Atypical Sphingolipids in healthy and diseased liver
open$634,062 - $634,062
Integrated fatty acid profiling unveils a linkage between BMI and efficacy of anti-tumor immunotherapy
open$129,285 - $129,285
Transcriptional co-activator PGC-1α promotes anti-tumor immunity in colorectal cancer
open$388,901 - $388,901
Quantitative Multiparametric PSMA PET MR to Optimize Treatment Planning for Partial Gland Ablation of Prostate Cancer
open$709,677 - $709,677
Precision Liver Cancer Modeling by CRISPR Editing of Primary Human Hepatocytes
open$412,249 - $412,249
Understanding inflammatory cell death as a driver of VEXAS pathogenesis
open$294,451 - $294,451
Novel mediators of cell-cell fusion in triple negative breast cancer
open$150,898 - $150,898
Targeting PTPN22 for Novel Cancer Immunotherapeutic Agents
open$593,249 - $593,249
Computational prediction of anti-cancer drug metabolizing enzymes in the human microbiome
open$747,790 - $747,790
Unveiling the origin of tumor-reactive regulatory T cells in patients with mismatch repair proficient colon cancer
open$437,113 - $437,113
Fluorescence lifetime imaging for quantitative assessment of in vivo PD-L1 target engagement.
open$437,113 - $437,113
Delineating the role of 5’ untranslated regions in prostate cancer clonality
open$723,547 - $723,547
Image-guided adaptable CAR T cell therapy for solid tumors
open$415,257 - $415,257
Single Cell-Resolution Imaging of Drug Resistance via Toxic Metal Pre-exposure in Lung Patient Tumor Microenvironment
open$395,973 - $395,973
Discovery of novel small molecules targeting a circadian regulatory complex for cancer therapeutics
open$680,452 - $680,452
Prospective Detection and Monitoring of NF1 peripheral nerve sheath tumors using cell-free DNA
open$688,661 - $688,661
Development of Genomic Risk Prediction Models for T-cell Malignancies
open$276,545 - $276,545
Post-diagnosis changes in body composition and renal cell cancer survival
open$411,705 - $411,705
Targeting subtype specification as a driver of PDAC health disparities
open$394,687 - $394,687
RECONJOINT: A Preference Elicitation Tool to Improve Shared Decision Making for Breast Reconstruction Surgery
open$457,252 - $457,252
Delineating the role of TREM2 in chronic pancreatitis
open$374,006 - $374,006
Dual mRNA Therapeutics for Liver Metastatic Uveal Melanoma
open$399,829 - $399,829
Augmented-reality guided lumpectomy
open$395,973 - $395,973
Increasing Lung Cancer Screening Uptake Among High-Risk Emergency Department Patients
open$345,413 - $345,413
Role of cellular physical interactions in pancreatic cancer progression
open$567,264 - $567,264
Optimizing CD45-Targeted Astatine-211-Radioimmunotherapy for Malignant and Non-Malignant Blood Disorders
open$716,319 - $716,319
Personalized Spatial Regulatory Networks to Decode Breast Cancer Microenvironments
open$178,000 - $178,000
Optimizing gamma-delta T cell receptor-mediated signaling to improve cancer immunotherapy
open$156,000 - $156,000
Multiplex single-cell chemical genomics to identify small molecule modulators of tumor cell-intrinsic immunogenicity in glioblastoma
open$702,132 - $702,132
Urothelial Resurfacing with Irreversible Electroporation for Adjuvant Therapy of Bladder Cancer
open$706,479 - $706,479
Structure-function and mechanistic studies of a specific glycosyltransferase complex in fusion-driven pediatric gliomas
open$134,919 - $134,919
Overcoming Treatment Resistance by Targeting Polyploid Breast Cancer Cells with AI assisted Single-Cell Analysis
open$408,829 - $408,829
Virtual AI-Assisted Music Therapy for Anxiety Symptoms in People with Advanced Cancer (VIRTUOSO)
open$743,809 - $743,809
Regulatory Mechanisms of APOBEC3B Mutagenic Activity in Cancer
open$40,367 - $40,367
Rewire-CAN-Therapeutic Rewiring of Colorectal Cancer
open$182,639 - $182,639
Characterization of Germline and Somatic Genetic Variants in Langerhans Cell Histiocytosis Pathogenesis
open$321,000 - $321,000
Second-generation new-chemical-entity nanomedicine to target treatment resistance in pancreatic cancer
open$667,482 - $667,482
Clonal hematopoiesis as a targetable mechanism of resistance to therapy in thyroid cancer.
open$752,808 - $752,808
2026 Mammary Gland Biology Gordon Research Conference and Seminar
open$10,000 - $10,000
Advancing Renal Mass Diagnosis and Management through AI-Enhanced Decision Support Systems (RMM-DSS)
open$632,670 - $632,670
Lung cancer subtype risk stratification: Validation in real world cohorts
open$714,192 - $714,192
Effect of Bundling Home-Based Self-Collection for Cervical and Colorectal Cancer Screening: The My Body, My Test-4 Trial
open$645,317 - $645,317
Develop a human pluripotent stem cell-derived preclinical model for NUT Carcinoma
open$157,000 - $157,000
The molecular mechanisms underlying PHF6-mutation-mediated hematologic malignancies
open$544,988 - $544,988
Expanding the xenotopic toolbox for compartment-specific manipulation of redox stress in cancer
open$480,205 - $480,205
Microfluidic Isolation and Deep Learning-based Profiling of Subtypes of Circulating Tumor Cells during Epithelial Mesenchymal Transition
open$607,488 - $607,488
Targeting Epigenetic Vulnerabilities in Osteosarcoma to Enhanced Immunotherapy
open$426,828 - $426,828
Leveraging Social Media Influencers to Improve Anal Cancer Prevention
open$407,543 - $407,543
Ultrasensitive sequencing to detect local and circulating tumor burden as a driver of recurrence in patients with resectable pancreas cancer
open$120,403 - $120,403
Investigating the role of ZBTB7A in AML differentiation
open$543,984 - $543,984
Transcriptional and post-transcriptional drivers of Melanoma
open$534,325 - $534,325
Role of tumor biomechanics on drug-receptor engagement
open$648,579 - $648,579
Investigating the bidirectional tumor-host crosstalk in cachexia and pancreatic ductal adenocarcinoma
open$142,251 - $142,251
Chrono-Cuisine: Investigating Meal Timing Patterns and Cancer Susceptibility
open$395,973 - $395,973
Targeting YBX1 to enhance radiation sensitivity in very high risk medulloblastoma
open$482,624 - $482,624
Establishing the role of hypomorphic BRCA1 and BRCA2 variants in cancer risk, etiology and response to therapy
open$741,738 - $741,738
One-ended Break Repair in Mammalian Cells
open$524,110 - $524,110
Computational Approaches to Reconstruct the Evolutionary History of Cancer Metastases
open$688,073 - $688,073
Elucidate the mechanism of targeting MTR to enhance anti-tumor immunity in KRAS-driven lung cancer
open$516,808 - $516,808
Reframing BRCA1 Function: A Coordinator of Lagging Strand Synthesis
open$469,628 - $469,628
Spatial and Temporal control of gene therapy in CAR-T cells with ionizing radiation to improve local and distant control of solid tumors
open$651,674 - $651,674
An Antibody-Drug Conjugate Targeting CCRL2 to Improve Outcomes in High-risk MDS and MDS-related AML
open$155,479 - $155,479
Addressing Unmeasured Covariates in Source Cohorts with Transfer Learning for Survival Outcomes
open$421,685 - $421,685
Understanding the Implications of EP300 deficiency in Adult T-Cell Leukemia/Lymphoma
open$672,960 - $672,960
Investigating the Role of AR Extrachromosomal DNA (ecDNA) in Bipolar Androgen Therapy for Advanced Prostate Cancer
open$44,819 - $44,819
The Role of Estrogen Receptor in Regulating Breast Cancer Cell Invasion
open$544,929 - $544,929
THE INTEGRATED STRESS RESPONSE IN GBM PATHOGENESIS AND RESPONSE TO THERAPY
open$659,201 - $659,201
The role of ERBB signaling in ibrutinib-resistant mantle cell lymphoma
open$457,683 - $457,683
Changing the natural history of pancreatic ductal adenocarcinoma with cancer interception strategies
open$658,033 - $658,033
Cyclic Peptides as Adaptors for Universal CARs
open$379,644 - $379,644
Molecular Imaging of the Immune-Suppressive TME in Prostate Cancer
open$477,674 - $477,674
Controlling tumor-infiltrating regulatory T cell function by the IL-17-Ybx1 signaling pathway
open$484,918 - $484,918
Radiation-induced fate shift of neural progenitors toward endothelial-like cells in human cortical organoids
open$368,156 - $368,156
Cancer cells with hybrid epithelial and mesenchymal phenotypes for deformability-based classification
open$161,500 - $161,500
Defining determinants of the lineage identity program in lung cancer and therapeutic resistance
open$631,487 - $631,487
Growth in Medicare Advantage Enrollment and its Implications for Cancer Care Quality
open$83,811 - $83,811
Blood-based early detection of viral precancers
open$642,406 - $642,406
Elucidating the impacts of body composition and physical activity on anti-tumor immunity and cancer control in advanced stage high-grade serous carcinoma
open$713,312 - $713,312
Creating cancer-specific genotoxicity by targeting Cas9 nickase to focal gene amplifications
open$622,611 - $622,611
Physical and Functional Improvement via Cancer Rehabilitation Triaging (PIVOT) Trial
open$544,080 - $544,080
Multifunctional nanoparticles for improved immunotherapy of melanoma
open$640,113 - $640,113
Longitudinal Radio-pathomic Mapping of Non-Enhancing Tumor Growth in Glioblastoma
open$602,121 - $602,121
Engineering Salmonella-based Platforms for Immunotherapy Against Immunologically Silent Tumors
open$432,125 - $432,125
Defining Symptom Trajectories to Inform Risk-Stratified Approaches to Symptom Management in Children with Advanced Cancer
open$689,340 - $689,340
Identifying and characterizing a stimulatory immune checkpoint in macrophage immunosurveillance
open$733,864 - $733,864
Non-canonical functions of the mitochondrial fission protein Drp1 in ovarian cancer
open$638,771 - $638,771
Targeting the Golgi Secretory Pathway in Chromosome 3q-amplified Human Cancer
open$388,546 - $388,546
Using Artificial Intelligence to Estimate Personal Symptom Network for Cancer Survivorship Care
open$491,925 - $491,925
A Randomized Controlled Trial of Brief Behavioral Activation for Older Adult Cancer Survivors
open$731,503 - $731,503
Generation of syngeneic, mutation-driven melanomas in an autoimmune-prone mouse to improve therapeutic efficacy without immunotoxicity
open$635,581 - $635,581
Evaluating and Implementing a decision support intervention (DECIDES) for adolescents and young adults newly diagnosed with cancer
open$749,133 - $749,133
REWIRING ONCOGENIC PATHWAYS TO INDUCE CELL DEATH IN CHRONIC LYMPHOCYTIC LEUKEMIA
open$661,135 - $661,135
A novel "cap-linker" strategy to target oncolytic viruses to the tumor
open$499,568 - $499,568
Fragment-based targeting of EMT-mediated resistance in EGFR-mutant lung cancer
open$433,256 - $433,256
Defining fatty acid desaturase 2 (FADS2) as a novel therapeutic target in Ewing sarcoma
open$42,696 - $42,696
A Patient-Specific Magnetic Resonance Guided Focused Ultrasound System for Breast Cancer Treatment
open$625,791 - $625,791
Exploring autophagy as a cellular response to fusion oncogene-induced stress
open$35,446 - $35,446
Translation factor DAP5 selective mRNA translation and m6A mRNA methylation in breast cancer metastasis
open$585,482 - $585,482
Investigating the chromatin remodeling complex PBAF in small cell lung cancer
open$577,750 - $577,750
The MYC Transcription Factor Network: Elucidating Oncogenic and Tumor Suppressive Pathways
open$692,368 - $692,368
Elucidating roles of TRPS1 in regulating antitumor immunity
open$657,698 - $657,698
EBV Modulation of Genome Stability in B-cell Lymphoma
open$117,144 - $117,144
Identification and Characterization of Mutation-Induced Alternative Splicing Events in Cancer Using Multi-Omics Data
open$155,500 - $155,500
Decoding the stromal niches of antigen-presenting cancer-associated fibroblast in pancreatic ductal adenocarcinoma
open$501,803 - $501,803
Concomitant Inhibition of VAV3 and ERa to Treat High-Risk B-ALL
open$683,698 - $683,698
Topical Therapy for Cutaneous Precancerous Lesions: a Digitally-enabled Randomized Controlled Trial of Fluorouracil compared with Fluorouracil/Calcipotriene
open$704,028 - $704,028
Evaluating the Impact of a Novel Educational Intervention to Improve Timely Colposcopy Follow-Up and Treatment Among High-Risk Populations
open$702,461 - $702,461
Biomarker Levels and Illnesses Associated with Exposure to Noncombustible and Combustible Tobacco Products in Young Children
open$694,182 - $694,182
Interactive Functional Dynamics of Human K-Ras, Its Oncogenic Mutants and their Binding Partners
open$463,692 - $463,692
Dissecting mechanisms by which mRNA vaccines encoding nontumor antigens initiate antitumor immunity
open$136,270 - $136,270
Leveraging Health Systems to Optimize Regional Cancer Care Delivery
open$293,430 - $293,430
Bioengineering of covalent proteins for nuclear medicine applications
open$640,466 - $640,466
Evaluating the impact of nicotine pouch characteristics in the context of a combustible cigarette standard on overall tobacco product use
open$621,549 - $621,549
Translational Imaging Markers for Metabolic Potentiation of Immunotherapy
open$674,339 - $674,339
Spatially Controlled Priming of CAR T Cells in Solid Tumors via Focused Ultrasound
open$137,459 - $137,459
Regulation of de novo nucleotide synthesis and Glioblastoma response to radiochemotherapy
open$656,469 - $656,469
Methods for Microsimulation Model Calibration
open$439,639 - $439,639
Defining the Impact of Tumor Heterogeneity in Intrahepatic Cholangiocarcinoma
open$420,399 - $420,399
Targeting Mitochondrial Fusion in Colorectal Cancer
open$190,944 - $190,944
Investigating the molecular mechanisms of MYC-driven transcriptional reprogramming of the tumor microenvironment in prostate cancer
open$50,114 - $50,114
Microbial-based cancer therapy armored with membrane-bound cytokines for targeted immune modulation and safety-controlled delivery
open$669,278 - $669,278
Molecular mechanisms of Ras and Receptor Tyrosine Kinase Convergence on PI3K in cancer
open$636,345 - $636,345
Social Networks and Tobacco Cessation in High-Risk Populations
open$522,235 - $522,235
Uncovering the formation and function of fusion oncoprotein condensates in translocation renal cell carcinoma
open$643,861 - $643,861
Targeting Ribosome Biogenesis as a Non-Genotoxic Chemotherapy Strategy: Mechanistic Characterization of NVL Inhibition by Benzothiazepinones
open$639,514 - $639,514
Reconstructing transposable element activity in cancer via local assembly of long reads
open$369,075 - $369,075
Characterizing and therapeutically targeting pH-regulatory mechanisms in the perivascular and infiltrating niches of glioblastoma using amine CEST-EPI and a novel treatment platform
open$640,597 - $640,597
Unleashing IFN signal transduction to prime HNSCC immunogenicity
open$742,382 - $742,382
Identifying targets to mitigate immunotherapy-associated immune-related adverse events
open$703,423 - $703,423
Perfusion CT for liver radioembolization
open$409,141 - $409,141
In Vivo Engineering of Virus-Specific T Cells for CAR T Cell Therapy Against Multiple Myeloma
open$705,899 - $705,899
SLC13A3 in tumor resistance to immunotherapy
open$544,868 - $544,868
Disparities in AML treatment
open$422,649 - $422,649
Establishing Claudin-2 as a Biomarker For Surgical Identification of Colorectal Cancer
open$409,120 - $409,120
Predicting response to immunotherapy with hyperpolarized 13C MRI
open$421,685 - $421,685
Regulation of anti-tumor immunity by CX3CL1
open$518,090 - $518,090
Development of Antibody Chelator Conjugates for Targeted Radionuclide Therapy
open$648,992 - $648,992
Evaluating the Synergistic Therapeutic Effects of Retinoic Acid and the Proteasome Inhibitors in Neuroblastoma
open$467,968 - $467,968
Defining immune determinants oftransformation in MGUS/SMM
open$959,573 - $959,573
Qualitative Training Institute for Enhancing Cancer Research (CancerQTI)
open$323,623 - $323,623
Radiomic phenotypes for invasive and advanced breast cancer
open$722,914 - $722,914
Protein glutathionylation is essential for leukemia initiating cell survival.
open$533,245 - $533,245
Mechanistic dissection and targeting non-cell autonomous tumor promotion in DICER1 cancer predisposition
open$628,073 - $628,073
Ultra-rapid tumor burden measurements for molecularly-guided surgery
open$703,227 - $703,227
Role of JAK inhibition in quiescent cancer cells and their microenvironment
open$523,544 - $523,544
Identification of small molecule activators of Type I interferon signaling for cancer treatment
open$771,811 - $771,811
Cis-Regulatory Role of Alternative Promoters in Cancer
open$40,908 - $40,908
Energy balance and reproductive health after early-onset colorectal cancer
open$518,470 - $518,470
Identifying mechanisms of structural variant-induced gene activation in glioma
open$46,939 - $46,939
Light-Responsive Inorganic Compounds for Diagnosis and Therapy
open$565,569 - $565,569
Cellular and Molecular Mechanisms of Early onset colorectal cancer
open$130,490 - $130,490
Transcriptomic, Genomic, and Microenvironmental Heterogeneity in pancreatic precancer: subtyping, classification, and cross-comparison
open$123,823 - $123,823
Functions and mechanisms of ILC2s in trained immunity
open$684,252 - $684,252
Acetylation modulates T cell receptor signaling
open$498,582 - $498,582
Defining and exploiting therapeutically the role of the neuropeptide receptor PAC1 in tumor-infiltrating pericytes that drives melanoma progression.
open$508,651 - $508,651
Role of p73-mediated DR5 induction in therapeutic response to CDK inhibition.
open$560,863 - $560,863
Targeting Diet-Driven Inflammation for Colorectal Cancer Prevention in High-Risk Adults: A Biomarker-Guided Approach
open$654,226 - $654,226
Elucidating mechanisms underlying lung cancer lineage plasticity thatfacilitate adaptation and resistance to targeted therapy
open$719,951 - $719,951
Therapeutic mechanisms of targeting WRN in MSI colorectal cancer.
open$581,548 - $581,548
Advancing NEMO’s specific MRI detection of residual breast cancer using novel imaging platforms
open$484,944 - $484,944
Restoring anti-tumor immunity in chromosomally unstable tumors
open$681,818 - $681,818
Evaluation of genetic and epigenetic determinants of response in patients with accelerated and blast phase Myeloproliferative Neoplasm (MPNs)
open$444,590 - $444,590
Characterizing the SPOP-BRAF-mTORC1 signaling axis in melanoma pathogenesis
open$682,495 - $682,495
Interrogating PP2A to understand and treat high-grade endometrial carcinoma
open$512,292 - $512,292
Investigating age-dependent factors in the development and treatment of adrenal cancer
open$581,686 - $581,686
Towards Safe and Efficacious Medical Therapy for Patients with Clinically Non-Functioning Pituitary Tumors
open$475,401 - $475,401
Biomimetic Migrating Nanoparticles Targeting Tumor Stroma and Neural Invasion to Improve Pancreatic Cancer Therapy and Pain Control
open$602,170 - $602,170
Unraveling the Molecular Mechanisms of Immunotherapy-Associated Myocarditis
open$706,739 - $706,739
Reducing ReADmissions through Innovative ApplicatioNs of Telemedicine (RADIANT)
open$747,660 - $747,660
Decoding Long Noncoding RNA Networks in Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer
open$142,635 - $142,635
Leveraging Multimodal Signatures to Personalize Rectal Cancer Radiotherapy Choice
open$518,451 - $518,451
Naturally Occurring Canine Hemangiosarcoma as a Translational Model for Angiosarcoma
open$635,324 - $635,324
2026 Annual Meeting of the American Society of Pharmacognosy: Elevating Natural Products
open$10,000 - $10,000
Elucidating the function of NF2 in NF1 mutant peripheral nervous system tumors.
open$681,070 - $681,070
Characterizing the XRN1 exoribonuclease as a therapeutic target in non-small cell lung cancer
open$182,363 - $182,363
Sidney Kimmel Cancer Center LAPS Institutional Collaboration
open$544,790 - $544,790
Verifiable and Robust Deformable Image Registration for Precision Tracking of Diffuse Glioma Progression
open$50,114 - $50,114
Evaluation of Guideline-based Uptake of Indicated Diagnostic exams after AbNormal Cervical cancer screening test in safEty-net settings (E-GUIDANCE)
open$286,638 - $286,638
Investigating lipogenesis mediated resistance to cytotoxic therapy in PDAC
open$408,829 - $408,829
Human-mouse platform for data-driven patient stratification, target discovery, and validation in GBM
open$683,256 - $683,256
Combinatorial Pulsed Field Alation for the Treatment of Solid Tumors
open$590,791 - $590,791
Understanding and Therapeutic Targeting of Extramedullary Acute Leukemia
open$716,681 - $716,681
North American Star Consortium
open$1,770,712 - $1,770,712
Post-Transcriptional Regulation is a Therapeutic Vulnerability of Acute Myeloid Leukemia
open$54,107 - $54,107
Identifying Immune Mediators in BRCA1/2 Deficient High Grade Serous Ovarian Cancer
open$50,114 - $50,114
Clonal dynamics and non-genetic mechanisms mediating resistance to RAS inhibition
open$50,114 - $50,114
Unraveling the immunobiology of tumor-specific T follicular helper CD4 T cells
open$33,384 - $33,384
Advancing cancer vaccine design using deep learning to predict peptide-HLA class I binding and immunogenicity
open$43,056 - $43,056
Profiling the tissue microenvironment of Large Granular Lymphocyte Leukemia through cellular dynamics and genetic signatures
open$39,498 - $39,498
Axonal Control of Tumor Progression
open$694,133 - $694,133
Bioinspired virus-like nanovaccines boost CAR T and endogenous T cells in tandem against solid tumors with antigen heterogeneity
open$737,082 - $737,082
A CRISPR-based sensitive liquid biopsy for endometrial cancer using tumor-derived hallmarks (CRISPR SLEUTH)
open$650,513 - $650,513
Pre-Leukemic Hematopoietic Stem Cell Clonal Selection by the Adaptive Immune System
open$704,636 - $704,636
Investigating the role of incretin mimetics in reducing the risk of development and progression of multiple myeloma and its precursor conditions
open$466,125 - $466,125
A Randomized Controlled Trial On Improving Prostate Cancer Screening Among Black Men in Oklahoma Using A Community-Based mHealth Approach (Prostate Cancer Genius App)
open$592,731 - $592,731
Investigating the role of Cdkn2a in lung adenocarcinoma metastasis
open$158,499 - $158,499
Expand and pull: long-acting IL-7 and oncolytic virus to treat glioblastoma
open$645,185 - $645,185
Payload Selection to Maximize Multiple Mechanisms of Action for High Avidity Low Affinity Antibody Drug Conjugates
open$646,671 - $646,671
The International Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia
open$20,000 - $20,000
Optimization of a public neoantigen-based cancer prevention strategy
open$659,570 - $659,570
Exploiting Primed Inflammatory Signaling to Target SETD2 Deficient Renal Tumors
open$616,624 - $616,624
The role of apelin in the skeletal muscle during cancer cachexia development and recovery
open$42,647 - $42,647
Elucidation of targetable mechanisms sustaining immunosuppressive neutrophils in the brain tumor microenvironment
open$651,940 - $651,940
Radiation synthetic combinations in high-risk Ewing sarcoma
open$659,028 - $659,028
Mouse model for solid Epstein-Barr Virus-driven cancers
open$394,214 - $394,214
Endogenous HOCl-derived chloramines in skin inflammation and photocarcinogenesis
open$399,712 - $399,712
Immunogenomic determinants of response and resistance to neoadjuvant anti-PD-1 in resectable NSCLC
open$355,706 - $355,706
Development of B-cell-based vaccine for Glioblastoma
open$362,482 - $362,482
Clinical Translation of a Urine-Based Biomarker for the Detection of Residual Disease in Radical Cystectomy Candidates
open$263,670 - $263,670
Imaging Goggles for Fluorescence-Guided Surgery
open$623,432 - $623,432
Characterizing mutational signatures at hotspots of genetic instability in human cancer genomes
open$396,377 - $396,377
Clinical Translation of the First Meitner-Auger PET Theranostic
open$641,419 - $641,419
Cytokines and B cells controlling immune tumor microenvironment in hepatocellular carcinoma
open$695,634 - $695,634
Novel methods for the design, analysis and implementation of ELISpot experiments
open$484,387 - $484,387
Targeting a novel covalent RAS dimer in RASQ61 mutants-driven cancers
open$131,727 - $131,727
Organoid-immune cell culture modeling of therapeutic responses in cholangiocarcinoma
open$628,394 - $628,394
Utilizing Glycosaminoglycans as a Theragnostic Approach for Treating Platinum-Resistant Gynecological Malignancies
open$399,187 - $399,187
Sphingolipid-guided stratification and therapeutic opportunities in Acute Myeloid Leukemia
open$192,887 - $192,887
Molecular Mechanisms of Altered DNA Binding and Chromatin Regulation by FET::ETS Oncogenes
open$639,295 - $639,295
Integrated G Protein Circuitry for Cancer Cell Signaling Autonomy
open$637,509 - $637,509
Strategies to improve therapy to pancreatic cancer with targeted-nanoparticle
open$401,115 - $401,115
Prostate Cancer Cohort Consortium (PC3): A collaborative approach to an enigmatic cancer
open$62,367 - $62,367
Cysteine Acquisition and Utilization in Lung Adenocarcinoma
open$687,593 - $687,593
The Development of Radiotherapeutic Paradigms for Desmoplastic Small Round Cell Tumor
open$431,222 - $431,222
Interrogating and targeting co-inhibitory and co-stimulatory molecules in CAR T-cell Therapies
open$716,183 - $716,183
Optimizing neoadjuvant/adjuvant anti-PD-1 therapy for localized Renal Cell Carcinoma
open$740,020 - $740,020
Oxygen Sensing and Ferroptosis in Cancer
open$614,260 - $614,260
Defining and overriding mechanisms of in vitro and clinical resistance to the first highly active allosteric kinase inhibitor
open$700,338 - $700,338
ADAR1 promotes Okazaki fragment maturation and is a target for breast cancer therapy
open$589,841 - $589,841
Small molecule inhibitors of the proton-sensing receptor GPR68 for pancreatic cancer therapy
open$411,206 - $411,206
Dissecting mechanism of EPHX2 deficient Bladder Cancer and targeting metabolic and immunologic vulnerabilities
open$681,330 - $681,330
Identification of Novel Innate Immune Checkpoint Receptors
open$412,249 - $412,249
Improving Treatment Sensitivity through Syk using Novel Translational Models of Uveal Melanoma
open$415,000 - $415,000
Targeting Tr1 to enhance the efficacy of cancer vaccines
open$399,829 - $399,829
Protein Degradation Strategies to Overcome Menin Drug Resistance in Acute Leukemias
open$399,829 - $399,829
Harnessing TLR4 Signaling Pathways in CAR Dendritic Cells to Overcome Tumor Immune Tolerance
open$399,829 - $399,829
AI-Enhanced Perfusion MRI for Optimizing Y90 Particle Density in Radioembolization of Liver Cancer
open$640,956 - $640,956
Function and Therapeutic Implications of NRG3 in Breast Cancer Brain Metastasis
open$642,242 - $642,242
Deciphering the Role of Tumor Suppressor Gene Deficiencies in Modulating PDAC Response to Oncogenic KRAS Inhibition and Immunotherapy
open$141,195 - $141,195
A novel chemical strategy to harness the tumor specific biochemistry of human kallikrein 2 for prostate cancer theranostics
open$575,178 - $575,178
Colorectal Cancer Therapies Introduced Through Engineered Native Bacteria
open$671,226 - $671,226
Early detection of liver cancer among patients with cirrhosis and MASLD
open$399,829 - $399,829
Project 2: Targeting CXCR4 and Redox Metabolism for Targeted Alpha Therapy of Pulmonary Neuroendocrine Tumors and Carcinomas
open$404,300 - $404,300
Personalized Outreach and Multifaceted Interventions for Screening Enhancement (PROMISE) for Anal and Cervical Cancer Prevention and Treatment
open$2,336,229 - $2,336,229
Project 2: Adoptive Cell Therapies for Chordomas
open$319,676 - $319,676
Developmental Research Program
open$284,568 - $284,568
Neuroendocrine Tumor Specialized Programs of Research Excellence (SPORE) in Human Cancer
open$2,185,934 - $2,185,934
Core C: Biostatistics and Bioinformatics Core
open$250,568 - $250,568
Core A - Administrative & Outreach
open$224,008 - $224,008
Project 1: Targeting Tumor Phospholipase PLA2G10 for Cancer Immunotherapy
open$411,417 - $411,417
Project 3: Pharmacogenomic advancements for improved treatment of acute lymphoblastic leukemia in Latino children and adolescents
open$262,326 - $262,326
Intercellular Communication in Prostate Cancer Progression
open$416,992 - $416,992
Deconstructing and targeting aneuploidy in human cancer
open$477,848 - $477,848
Explainable Artificial Intelligence for Melanoma Recurrence Prediction via Integrative Modeling of Multiplexed Imaging with Transcriptomics and Histopathology
open$249,000 - $249,000
Cancer Research Training and Education Coordination
open$308,953 - $308,953
The Duke University - Duke Cancer Institute National Clinical Trials Network LAPS (UG1) Support Grant
open$634,423 - $634,423
Exploring ATR as a Novel Vulnerability of Osimertinib-Resistant EGFR-Driven Lung Adenocarcinomas
open$35,134 - $35,134
Spatial and Clonal Dynamics in Glioblastoma: Disentangling Drivers of Migration and Stemness
open$50,114 - $50,114
Modeling Minimal Residual Disease in Colorectal Cancer
open$415,257 - $415,257
Gastroshare: Integrating Electronic Health Systems to Improve the Management ofGastric Precursors across Multiethnic Populations.
open$661,643 - $661,643
Tumor Microenvironment: Identifying Drivers of Progression and Resistance
open$5,000 - $5,000
Investigating the Antioxidant Role of Lipoprotein Uptake in Kidney Cancer
open$41,819 - $41,819
Engineered mineralized hydrogels to study microcalcifications in breast cancer
open$565,909 - $565,909
A novel protective role of PYDC5 in colorectal cancer
open$679,353 - $679,353
Purdue Interdisciplinary Cancer Research Training
open$164,121 - $164,121
The 11th Annual Midwest Tumor Microenvironment Conference 05/18/2026-05/20/2026
open$15,000 - $15,000
Identification of chromatin regulators required for enhancer hijacking in cancer genomes
open$795,143 - $795,143
Reprogramming inflammatory fibroblasts to overcome therapeutic resistance in pancreatic adenocarcinoma
open$357,370 - $357,370
Jumonji KDM5 enzymes mediate resistance to CDK4/6 inhibitors in Breast Cancer
open$426,828 - $426,828
Measuring Provider and Intervention Characteristic Determinants of Evidence-Based Cancer Care
open$737,945 - $737,945
Impact of KEAP1/NRF2 on therapy response in lung neuroendocrine cancers
open$712,569 - $712,569
Cross-species transfer learning for liquid biopsy-based cancer detection
open$402,068 - $402,068
Functional genomic dissection of lung cancer in vivo
open$635,340 - $635,340
Accelerated Biological Aging and Immunosenescence as Drivers for Racial Disparities in Monoclonal Gammopathy of Undetermined Significance (MGUS)
open$558,016 - $558,016
Programmable Multiplexed Detection of Cell-free DNA Mutation for Liquid Biopsy
open$414,585 - $414,585
Targeting the Hippo-YAP/TEAD Signaling Network in Head and Neck Cancer
open$694,643 - $694,643
The RUNX1 Research Program 10th Annual Scientific Conference and Patient Meeting
open$10,000 - $10,000
Integrating nutrition and proteomics to improve chemotherapy-induced peripheral neuropathy in cancer survivors
open$176,256 - $176,256
Development of an F-18 Imaging Agent to Measure Glioma IDH1mut Expression
open$402,401 - $402,401
Single-Cell Signaling Network Profiling of Pooled CRISPR Screens by Mass Cytometry
open$406,325 - $406,325
The mechanism and therapeutic potential of Parkin in colorectal cancer
open$542,316 - $542,316
Fragment-based drug discovery against oncogenic microRNA precursors using high-throughput crystallography.
open$528,265 - $528,265
Dissecting Inter-Compartmental Tumor-Host Communication Driving Early Dissemination in Uveal Melanoma.
open$573,286 - $573,286
Dual imaging of pHi and pHe to dissociate glycolytic/oxidative phenotypes for novel GBM therapeutics
open$607,690 - $607,690
Single-cell Joint Profiling of Single- and Double-Stranded DNA Breaks with Transcriptome
open$270,683 - $270,683
Advanced development and validation of aliquot-level visual indicators of biospecimen exposure to thawed conditions
open$353,601 - $353,601
Immune microenvironment in brain metastais
open$554,732 - $554,732
2026 Nasopharyngeal Carcinoma Gordon Research Conference
open$15,000 - $15,000
Leveraging the GTP Biosynthetic Pathway for Anti-Tumor Therapies
open$396,881 - $396,881
Deciphering cancer origin from DNA evolution
open$428,975 - $428,975
Identifying spatial tumor microenvironment signatures for risk stratification in primary melanoma
open$693,290 - $693,290
MedMemos: A Program to Promote Medication Adherence in Pediatric Hematopoeitic Stem Cell Transplantation
open$406,258 - $406,258
Reprograming T cell function through BCL-2 family protein:protein disruption
open$588,289 - $588,289
Northwestern University Lead Academic Participating Site
open$1,139,381 - $1,139,381
Multiplexed multiscale imaging for cellular immunotherapies
open$207,802 - $207,802
Methodological Training for Social and Behavioral Research in Cancer Control
open$162,501 - $162,501
Defining the role of MAFG in melanocyte transformation and melanoma development
open$607,249 - $607,249
Exploring the Novel Functions of Cyclin Ds in T Cells and Tumor Progression
open$643,053 - $643,053
Adaptation and Evolution of Resistance to Pan-RAS inhibition in PDAC
open$682,673 - $682,673
Mapping the m3C epitranscriptome in cancer
open$167,500 - $167,500
The first clinical prototype for proton minibeam radiation therapy
open$683,885 - $683,885
Investigating the role of cell cycle plasticity in the growth and progression of bladder cancers
open$412,856 - $412,856
Single-Cell Multi-omics 3D Genome Technology for Cancer Structure Variation and Enhancer Hijacking
open$402,135 - $402,135
Assessing the impact of early physiotherapy on lymphatic dysfunction in breast cancer survivorship
open$663,818 - $663,818
Bioprinted 3D vascular cancer model
open$604,102 - $604,102
Therapeutic Restoration of Cholangiocyte Primary Cilia via Microbiota-Derived Butyrate: A Novel Approach for Bile Duct Cancer
open$408,829 - $408,829
Multi-Modality Modeling of Glioblastoma Progression: Integrating DTI and Prognostic Biomarkers for Personalized Radiation Therapy Targeting
open$414,402 - $414,402
Neighborhood Disadvantage and Obesity-Related Cancer Incidence in US Hispanics/Latinos: The Biobehavioral and Social Pathways
open$199,584 - $199,584
Targeting cell death pathways to prevent KRAS inhibitor resistance
open$166,000 - $166,000
POLE-mutant Tumors: Mechanisms of Genomic Instability and Discovery of New Driver Alleles
open$584,852 - $584,852
Tumor Cell Autonomous and Non-Autonomous Mechanisms of Lipocalin-2 Function in Metastasis
open$545,000 - $545,000
Modeling neuroendocrine bladder cancer for studying the pathogenesis and improving chemotherapy responses
open$639,379 - $639,379
Low Molecular Weight Theranostics for Multiple Myeloma
open$591,419 - $591,419
Functional characterization of the lineage plasticity landscape of cholangiocarcinoma
open$510,671 - $510,671
Investigating Type I Interferon response and differentiation in FLT3-inhibitor persistent acute myeloid leukemia
open$434,969 - $434,969
Targeting non-genetic and genetic mechanisms to overcome drug resistance in acute myeloid leukemia
open$639,859 - $639,859
New FADS diet for endocrine resistant breast cancer
open$625,470 - $625,470
Risk-Based Prostate Cancer Screening: Perceptions and Informational Needs of Screening-Eligible Men
open$160,093 - $160,093
Myeloid Phagocyte Activation by Commensal-Activated Complement C5aR1 Signaling: Implications for Tumor-Directed Lymphocyte Response
open$467,261 - $467,261
Pangenome-Aware Methods for Accurate Somatic Variant Discovery in Cancer Genomics
open$593,867 - $593,867
Medicare Advantage and cancer care for older adults
open$649,620 - $649,620
Breaking the Myeloid-Stromal Axis to Treat Colorectal Cancer
open$697,131 - $697,131
Multilevel, Faith-based Intervention to Promote Rural Physical Activity
open$115,420 - $115,420
Optimization of a multicomponent intervention to foster functional recovery after breast cancer treatment
open$696,498 - $696,498
Identifying Mechanisms of Implementation Strategies for Cancer Control: An Implementation Mapping Approach
open$401,115 - $401,115
Innate & Adaptive Determinants of Post-CAR Cytokine Release Syndrome
open$452,540 - $452,540
Assessing multi-level predictors of diagnostic follow-up attendance after an abnormal cervical cancer screen
open$155,000 - $155,000
Biomarker Development and Applications to Inform Cancer Prevention
open$309,761 - $309,761
Microenvironmental and hepatocyte cell type specific regulation of colorectal cancer metastasis by IL17
open$708,990 - $708,990
Randomized Trial of a Dissonance-Based Sun Safety Intervention for Young Adult Tanners
open$444,991 - $444,991
Harnessing Androgen-Driven Immune Modulation to Enhance Immunotherapy for Endocrine Cancers
open$126,933 - $126,933
AI-CChaSE: AI-enabled Cancer CHatbots for Symptom Education
open$819,628 - $819,628
Investigating the Impact of Obesity and Androgen Receptor Signaling on BRAF/MEKi Resistance in Melanoma
open$291,498 - $291,498
Proteomics-driven analysis and robotics-enabled drug testing of microdissected tumors and their microenvironment
open$686,271 - $686,271
HiJAKing the System: Investigating the Impact Mechanisms of Low Variant Allele Frequency JAK2V617F Clone on the Pathobiology of Myeloproliferative Neoplasms
open$688,917 - $688,917
Characterization of the functions of the DNA translocase SMARCAL1 in anti-tumor immunity
open$630,089 - $630,089
Spatial heterogeneity of Her2 expression in luminal breast cancer
open$646,208 - $646,208
Novel selective allosteric modulators of PTHrP/PTH receptor to inhibit prostate cancer metastases
open$418,822 - $418,822
MTAP-MAT2A synthetic-lethality induced by transition state analogs
open$692,197 - $692,197
Spatiotemporal molecular elucidation of radiation-induced tumor microenvironment remodeling to en-hance immunotherapy in head and neck cancer
open$715,710 - $715,710
Circulating senescent proteins and their trajectories in relation to age-related outcomes in cancer survivors
open$399,852 - $399,852
Investigating T cell Circuits in the Lymphatic System During Melanoma Progression
open$695,852 - $695,852
NEUROD1 and cell fate plasticity in olfactory neuroblastoma
open$610,459 - $610,459
Lung Cancer Care and Prognosis: Medicare Advantage vs Traditional Medicare
open$425,088 - $425,088
Microbiome-metabolome signaling interactions reduce obesity-mediated breast cancer risk
open$622,071 - $622,071
Therapeutic Targeting of Upregulated BAP1 in Human Hepatocellular Carcinoma
open$402,401 - $402,401
Menin and Ewing Sarcoma Metastasis
open$636,097 - $636,097
Leveraging Causal Machine Learning Methods to Enhance Tobacco Control Interventions
open$158,895 - $158,895
Regulation of tumorigenic G protein signaling by novel post-translational mechanisms
open$428,396 - $428,396
Development of Novel Biomarkers for Diagnosis of Malignant Pleural Effusion
open$449,969 - $449,969
Assessment of efflux transport, pharmacokinetics and systems pharmacology impact on MMAE induced neurotoxicity
open$410,545 - $410,545
Dissecting the Metabolic Rewiring Mediated by SMARCB1 Loss in Metastatic Bladder Cancer
open$160,000 - $160,000
The role of ASAH1-driven ceramide metabolism in EBV B-cell transformation under physiologically relevant germinal center hypoxia
open$415,994 - $415,994
Defining the role of TTK in neuroendocrine prostate cancer
open$607,157 - $607,157
Control of T-cell stemness and T-cell exhaustion by KEAP1-NRF2 axis
open$402,011 - $402,011
The biology and phenotypic consequences of B-cell clonality driven by mosaic chromosomal alterations
open$235,491 - $235,491
Overcoming chronic inflammation-driven T cell quiescence in gastric adenocarcinoma
open$730,097 - $730,097
3D Bioprinted In Vitro Model: A New Research Tool for Investigating Bidirectional Communication in Chondrosarcoma
open$154,917 - $154,917
Evaluating inherited genetic variation and outcome among children andadolescents treated for acute myeloid leukemia
open$339,911 - $339,911
Methylation Changes in Viral and Host DNA in Blood as Biomarkers for Early Detection of Lymphomagenesis in HIV-Infected Individuals
open$677,621 - $677,621
Defining the cell intrinsic and tumor immune microenvironment mechanisms of DNA-PKcs in radiotherapy resistance in glioblastoma
open$286,881 - $286,881
Optimizing Medicaid Managed Care to Improve Access, Quality, and Clinical Outcomes for Patients with Gastrointestinal Cancers
open$212,332 - $212,332
Novel Antibody-drug Conjugates for Gamma-Delta T-cell Cancers
open$644,632 - $644,632
Role of ATAD2 in Prostate Cancer Progression and Metastasis
open$682,886 - $682,886
Defining the impact of detachment sensing proteins in ovarian cancer metastasis
open$638,422 - $638,422
Vision-Language Models with Explainability for Breast Cancer Prognosis using Image and Clinical Data.
open$825,627 - $825,627
Advancing a novel synthetic lethal target by exploiting ribosomal stress in Ch9p21.3-deleted or MSI-H cancers
open$501,422 - $501,422
In Vitro Human INtraDuctal (HIND) Model of Early Stage Breast Cancer Progression Heterogeneity
open$396,406 - $396,406
A novel combination therapy for recurrent ovarian cancer
open$403,686 - $403,686
Spatial and functional profiling tumor evolution trajectories and microenvironment interactions of VHL driven renal cancers
open$131,933 - $131,933
Exploring host GSK3β-53BP1 axis in immune control of solid tumor progression
open$628,980 - $628,980
Understanding Tumor Suppressive Functions of Protein Phosphatase 2A
open$651,038 - $651,038
The Massey/VCU’s McCaskill-Stevens K12 for Community Oncology and Prevention Research
open$54,000 - $54,000
Stanford Cancer Research Education Program (SCREP)
open$140,670 - $140,670
A pilot adaptive trial of FITtrack chatbot, nurse navigator, and peer navigator to promote FIT screening among rural residents.
open$380,554 - $380,554
Characterizing the cooperative role of E2F1 and interacting proteins in driving advanced prostate cancer
open$169,291 - $169,291
Metabolic Gatekeeping of Dormancy in Disseminated NSCLC Subpopulations
open$572,378 - $572,378
Cancer Health Disparities SPORE in Endometrial Cancer
open$2,255,110 - $2,255,110
Project 2
open$416,073 - $416,073
Core A: Biospecimens and Pathology Core
open$250,569 - $250,569
Roles of mRNA transfer in cancer cell-platelet communication
open$294,940 - $294,940
Biomaterial-Enhanced CAR-T/NK Cell Therapies for Glioblastoma.
open$2,554,662 - $2,554,662
Dual targeting of AML by BCL-2 inhibition and by CD123-directed NK engager/NK cell immune therapies
open$431,970 - $431,970
Establishing Ethical Standards for Informed Consent and Counseling for Multi-Cancer Early Detection Testing
open$134,919 - $134,919
Development of autologous humanized leukemia models for immunotherapy testing
open$573,262 - $573,262
Building upon a tradition of excellence. The NCTN at IUSCCC
open$366,921 - $366,921
Abramson Cancer Center Lead Academic Participating Sites (LAPS)
open$368,701 - $368,701
Large-scale artificial intelligence using radiomics, deep learning, and physics-based generative modeling to improve clinical outcomes in nuclear medicine
open$249,000 - $249,000
An Integrated Image-Enabled Computational Model for Lung Cancer Intratumoral Therapy
open$595,012 - $595,012
Macrophage-directed strategies for BRCA-associated breast cancer
open$772,208 - $772,208
Identifying immune-mediated mechanisms of RAS inhibitor efficacy and resistance in pancreatic cancer
open$384,630 - $384,630
2026 Annual Conference Grant: American Society of Preventive Oncology
open$40,000 - $40,000
Investigating BCAA oxidation and signaling in macrophages to drive anti-tumor immunity in PDAC
open$780,764 - $780,764
Metabolic Imaging Using Hyperpolarized Agents at Tracer Concentrations
open$415,623 - $415,623
Disrupting the Peri-necrotic Engine of Immunosuppression in Glioblastoma
open$496,357 - $496,357
Targeting tumor architecture as a novel therapeutic strategy for pancreatic cancer
open$458,086 - $458,086
Roles of Hsp47 in breast cancer progression
open$267,208 - $267,208
Energy balance, mTOR pathway signaling, and breast cancer prognosis
open$766,371 - $766,371
Targeting Nucleotide Metabolism to Overcome Therapy Resistance in Glioblastoma
open$554,814 - $554,814
Molecular mechanisms of T cell responses to a clonal neoantigen resulting from a mutated driver oncogene.
open$538,178 - $538,178
The Role of Clonal Hematopoiesis in Lung Cancer: Immune Dysregulation and Therapeutic Targeting
open$646,181 - $646,181
Mechanisms of immunosuppression triggered by checkpoint blockade immunotherapy
open$648,626 - $648,626
Novel Treg inactivating approach for cancer immunotherapy via targeted protein degradation
open$482,312 - $482,312
Protoacoustic Imaging for 3D Mapping the Bragg Peak in Real Time during Proton Therapy
open$648,049 - $648,049
Type 1 Innate Lymphoid Cells: Mechanisms and Anti-AML Potential
open$586,364 - $586,364
Targeting androgen-driven resistance to immune checkpoint inhibitors in pancreatic ductal adenocarcinoma
open$402,401 - $402,401
Development of miRNA-based approach for pediatric high-grade gliomas
open$544,520 - $544,520
Defining the determinants of long term CAR-T persistence
open$703,071 - $703,071
Pre-Clinical Evaluation of a Highly Selective SMARCA2 Degrader in Therapy-Resistant Triple-Negative Breast Cancer
open$398,544 - $398,544
Durability of memory T cell responses in melanoma
open$660,808 - $660,808
Targeting oncogenic KRAS to sensitize pancreatic cancer to NK cell immunotherapy
open$47,827 - $47,827
Investigating mechanisms of CD8 T cell differentiation in the tumor-draining lymph node
open$696,189 - $696,189
2026 Annual Meeting of the American Society for Investigative Pathology
open$10,000 - $10,000
Discerning the role of CDK10 in driving aggressiveness and disparities of triple negative breast cancer
open$403,686 - $403,686
Proline tRNA biogenesis as oncogenic drivers and therapeutic target in T cell acute lymphoblastic leukemia
open$473,372 - $473,372
Shared Resources Core: Ferroptosis Biomarkers and Lipidomic Analysis
open$326,204 - $326,204
Project 3: Development of Novel Antibody Drug Conjugates for the Treatment of Osteosarcoma
open$477,912 - $477,912
Epigenomics Core
open$394,295 - $394,295
Defining the roles of mutant p53 and Mdm2 in metastasis
open$537,052 - $537,052
Technology Facilitated Behavioral Intervention for Depression among Diverse Patients in Ambulatory Oncology
open$742,929 - $742,929
Data Analytics Training And Professional Development (DATA-Pro) for Behavioral and Social Sciences Research
open$215,976 - $215,976
A microphysiological model of prostate cancer metastasis into vascularized and innervated bone
open$521,002 - $521,002
Targeting YB-1 to overcome chemoresistance in ovarian cancer
open$356,850 - $356,850
Dormancy and Pancreatic Adenocarcinoma Recurrence
open$168,000 - $168,000
Tumor-penetrating stromal modification of β5 integrin-rich pancreatic cancer
open$683,970 - $683,970
Targeting EZH2 in advanced prostate cancer
open$497,972 - $497,972
Defining the pathogenesis of gammaherpesvirus and Plasmodium coinfections
open$460,548 - $460,548
Structure and function related biomarkers and computational models for predicting adenoma recurrence in patients with advanced adenomas
open$396,799 - $396,799
Targeting CXCR4 and Redox Metabolism for Alpha Particle Therapy of Pulmonary Neuroendocrine Tumors and Carcinomas
open$628,280 - $628,280
Novel Dual Agent HP C-13 MRI for Quantitative Imaging of Prostate Cancer Aggressiveness for Improved Biopsy Guidance
open$679,290 - $679,290
Rational Design of Next-Generation Engineered T Cells for Enhanced Cancer Immunotherapy
open$399,829 - $399,829
Universal methylated ctDNA markers for minimal residual disease detection and therapy response prediction in colorectal cancer
open$662,610 - $662,610
Enhancing drug delivery to treat high-risk neuroblastoma
open$457,683 - $457,683
Development of active site directed inhibitors and bifunctional degraders of isocitrate dehydrogenase mutants
open$435,788 - $435,788
Radiation-guided antibody-drug conjugates for cancer therapy
open$542,644 - $542,644
Optimizing Pre-clinical Models of Admantinomatous Craniopharyngioma
open$156,000 - $156,000
Decoding Dural Nociceptors as Drivers of Immune Suppression in Glioblastoma
open$390,906 - $390,906
Stratifying Underlying Risk in the Prostate cancer Active Surveillance Study (SURPASS)
open$688,959 - $688,959
Emergence of tumor regenerative states during neoadjuvant therapy in locally advanced rectal cancer: selection or adaptation?
open$736,623 - $736,623
Investigating the Role of B-cells in Durable Complete Responses to Immunotherapy in Head and Neck Cancer
open$650,597 - $650,597
Longitudinal Dynamics of Blood Microbiome and Circulating Tumor Cell in Metastatic Breast Cancer
open$170,930 - $170,930
Understanding mechanisms of immunoevasion by precancer stem cells for breast cancer interception
open$680,121 - $680,121
Deciphering the mechanisms of resistance to anti-TROP2 cancer therapy using novel humanized mouse models
open$431,970 - $431,970
Understanding plant virus-based adjuvants as therapeutics
open$420,505 - $420,505
Dissecting the role of CPT1C in advanced prostate cancer
open$551,328 - $551,328
Drug-loaded degradable biopolymeric scaffolds for augmenting preoperative liver growth
open$680,129 - $680,129
Quantification of Focused Ultrasound-Mediated Macromolecular Delivery to Brain Tumors with MRI
open$404,349 - $404,349
The Implementation of Local Flavored Cigar Restrictions
open$654,688 - $654,688
Discovery and synthesis of cryptic enediynes and microbial cytotoxins
open$544,480 - $544,480
Bioengineering for Optimization of Locoregional Treatment of Advanced Melanoma
open$610,637 - $610,637
Gallium maltolate for the treatment of difficult-to-treat high-grade pediatric brain tumors
open$632,314 - $632,314
A Single, Universal, and Digitally Programmable RF System Enables MRI of Any Nucleus
open$712,375 - $712,375
PFAS and liver cancer: linking epidemiological evidence with mechanistic studies
open$681,676 - $681,676
Explore niche-leukemic stem cell interactions and evaluate niche-directed leukemia treatments
open$486,426 - $486,426
Targeting ASH1L histone methyltransferase in leukemia
open$646,881 - $646,881
Essential roles of noncanonical signaling of JAK1 and JAK2 in mammary gland development and breast cancer
open$371,024 - $371,024
Intratumor Heterogeneity as a Correlate of Clinical Outcome in Patients Avoiding Radical Cystectomy
open$766,439 - $766,439
Regulation of Immunometabolism by the Integrated Stress Response in Cancer
open$624,194 - $624,194
Systematic functional mapping and interrogation of oncogenic intrinsically disordered regions
open$661,721 - $661,721
Targeting mucin-type O-glycosylation for EGFR mutant non-small cell lung cancer
open$609,846 - $609,846
Functional Avoidance Liver Stereotactic Body Radiation Therapy Guided by MR Multitasking-driven Abdominal Integrated Imaging (MT-AI2)
open$700,838 - $700,838
Modulation of the tumor microenvironment by Fusobacterium nucleatum and co-infecting microbes in colorectal cancer
open$660,541 - $660,541
HER2 PET imaging to assess HER2 heterogeneity and predict response to HER2-targeted therapy in biliary tract cancer
open$715,002 - $715,002
Bundled Outreach of Multiple Cancer Screenings for Under-screened Populations (BUNDLE)
open$596,996 - $596,996
Peptide-drug conjugates targeting EGFR for improved efficacy of chemotherapy
open$534,925 - $534,925
The Lymphoma Epidemiology of Outcomes (LEO) Cohort Study
open$1,264,356 - $1,264,356
Validation and Credentialing of Patient-Derived Xenograft Models of Hepatocellular Carcinoma Using Patient Level Data
open$667,041 - $667,041
Genome-Wide In Vivo CRISPR Screens in Human T Cells Identify GPCR Pathway Targets to Enhance CAR-T Therapies for Solid Tumors
open$680,597 - $680,597
Leveraging radiation to sensitize breast cancers to T-DXd
open$402,401 - $402,401
Genetically and metabolically defining high-risk neuroblastoma to exploit effective therapeutic strategies
open$608,558 - $608,558
Interrogating Erythroid Differentiation and BCL-XL Axis in TP53-mutated Acute Myeloid Leukemia
open$442,816 - $442,816
CD44 splice variants as novel antibody-targets for advanced breast cancer
open$668,878 - $668,878
Myeloid cell-derived interleukin 1b promotes chemoresistance in metastatic ovarian cancer
open$473,624 - $473,624
Protein-nanoparticle interaction to study multicellular crosstalk within ovarian tumor microenviroment
open$326,103 - $326,103
Targeting cellular senescense in pancreatic cancer
open$201,961 - $201,961
Decode polyadenylation in health and disease
open$667,379 - $667,379
A BCR transgenic mouse model to study glycan-specific B cells
open$169,329 - $169,329
Supportive Tailored Exercise Program for Survivors of Breast Cancer (STEPS-BC)
open$671,757 - $671,757
Mini-reflectance confocal microscope (Mini-RCM) for aiding skin cancer diagnosis and treatment
open$400,000 - $400,000
Feasibility and Adaptation of an Evidence-Based Multilevel Intervention for Improving Timeliness of Lung Cancer Treatment
open$68,400 - $68,400
PD-L1 MODIFICATIONS IN CANCER DIAGNOSIS AND TREATMENT
open$678,723 - $678,723
Developing purinergic receptor inverse agonists for treating triple negative breast cancer
open$616,071 - $616,071
Advanced PET/MRI to quantify heterogeneity of HER2 and vasculature in HER2+ breast-to-brain metastasis prior to combination targeted and radiotherapy
open$204,295 - $204,295
Selective treatment of acute myeloid leukemia with radioimmunotherapies targeting the active conformation of integrin beta-2
open$678,334 - $678,334
Immune Checkpoint Blockade Targeting the Novel PSGL-1/VISTA Axis for Pancreatic Cancer
open$268,345 - $268,345
Genes regulating stem and progenitor cell expansion and relapse in Acute Myeloid Leukemia
open$458,698 - $458,698
The role of oral microbiota in metastatic brain tumors
open$112,026 - $112,026
Precision use of radiation for in situ cancer immunization
open$198,103 - $198,103
Leadership, Planning and Evaluation
open$319,829 - $319,829
Targeting CDK4/6 as an interception strategy for intraductal papillary mucinous neoplasia
open$166,037 - $166,037
A Novel Approach to Enhance Therapeutic Efficacy of Tarlatamab for Small Cell Lung Cancer Treatment
open$173,559 - $173,559
Role of Disadvantage, Mutographs and T Cell Immunity on MGUS in African Americans
open$509,510 - $509,510
Effects of combined FAK inhibition with MAPK blockade in brain metastases from cutaneous melanoma
open$634,900 - $634,900
Longitudinal Imaging and Liquid Biopsy Markers of Prostate Cancer Radiotherapy Outcomes
open$538,553 - $538,553
The effect of aging on cDC1 function and CD8 T cell immunity in tumors
open$176,040 - $176,040
Novel Immunotherapy Targeting Local and Systemic Immunity for Treatment of Ocular Surface Squamous Neoplasia
open$179,988 - $179,988
Detection and elimination of drug tolerant persister cells in small cell lung cancer
open$424,836 - $424,836
ASHES: Assessing Smoking BeHavior with ThErmal Sensing to Prevent Relapse
open$399,891 - $399,891
A Novel Immune Tolerization Strategy for Investigating the Trade-offs between Oncogene Pathogenicity and Immunogenicity.
open$50,114 - $50,114
Decentralized Clinical Trial of Effectiveness of EnergyPoints App to Guide Acupressure Use for Fatigue and Sleep Disturbances in Cancer Survivors
open$1,019,587 - $1,019,587
Determining the Mechanism of Rhabdomyosarcoma Transformation from a Non-Myogenic Cell of Origin
open$49,114 - $49,114
Free energy-based active learning for ligand off-target and multitarget activity
open$50,114 - $50,114
Upstate Carolina Consortium - Community Oncology Research Program
open$3,234,639 - $3,234,639
Tailoring a fun and engaging tech-assisted cognitive behavioral therapy program for adolescents and young adults with hematological malignancies: A planning grant
open$361,807 - $361,807
Montana Cancer Consortium: An Inclusive and Collaborative Approach to Clinical Trial Accrual and Cancer Care Delivery Research across Montana, Idaho and Wyoming
open$755,012 - $755,012
Children's Oncology Group NCI Community Oncology Research Program (NCORP) Research Base grant
open$4,604,595 - $4,604,595
URCC NCORP Research Base
open$5,649,423 - $5,649,423
The Florida Pediatric NCORP: NCI Community Oncology Research Program.
open$683,297 - $683,297
Development of VNPP433-3Beta as Novel Therapeutic for All Stages of Prostrate Cancer
open$1,022,522 - $1,022,522
Modeling Precision Interventions for Prostate Cancer Control
open$64,000 - $64,000
Reprogramming of myelopoiesis by DNMT3A mutation in lung cancer
open$50,698 - $50,698
Comparative Modeling of Effective Policies for Colorectal Cancer Control
open$200,000 - $200,000
Quantitative and Spatially-Resolved Analysis of the Tumor Immune Contexture for Optimal Diagnosis and Treatment of Lung Cancer
open$722,919 - $722,919
Role of STAT in heterochromatin initiation
open$159,500 - $159,500
Enriching Neuro-Oncology Survivorship: A Novel Symptom Management Education to Living Fully (SELF)
open$140,854 - $140,854
Clinical Oncology Research Program (CORP)
open$54,000 - $54,000
Targeting mutant-MYOD1 driven rhabdomyosarcoma
open$481,052 - $481,052
The MYC-SWI/SNF connection in cancers defined by SMARCA4 mutations
open$549,836 - $549,836
Microfluidic immunotherapy screening on a core needle biopsy
open$386,279 - $386,279
Development of a novel dual inhibitor for treatment of MYCN-amplified neuroblastoma
open$131,300 - $131,300
NRG Oncology NCORP Research Base-BIQSFP
open$484,899 - $484,899
TIP60-chromatin remodeling complex roles in chromosome break repair
open$157,500 - $157,500
Overcoming resistance to menin patient mutations in leukemia
open$640,135 - $640,135
Development of a novel visualization, labeling, and tracking engine for human anatomy.
open$1,116,368 - $1,116,368
Mechanisms of glioma initiation by IDH oncogenes
open$656,879 - $656,879
Pediatric Early Phase Clinical Trials Network (PEP-CTN) Transfer Application
open$4,394,441 - $4,394,441
The role of bacterial dysbiosis and its influence on pancreatic cancer cell behavior
open$43,582 - $43,582
Engineering CD4+ T cells to develop a novel immunotherapy for pancreatic cancer
open$51,038 - $51,038
Replication Gap Suppression by Translesion Synthesis Promotes Drug Resistance in hard-to-treat cancers
open$3,000 - $3,000
Transposable Element Regulation and Expression During Cancer Progression
open$46,329 - $46,329
Functional Interrogation of Germinal Center Independent Memory B Cells in Head and Neck Cancer
open$49,538 - $49,538
Investigating Extrachromosomal DNA (ecDNA) Segregation and Repair in Cancer
open$3,201,530 - $3,201,530
Targeting mechanisms of chromatin plasticity to improve the efficacy of epigenetic solid tumor therapy
open$3,000 - $3,000
Targeted Radiotheranostics: Bench to Bedside
open$149,394 - $149,394
Sequential infection of laboratory mice for enhanced cancer and immunotherapy translation
open$138,846 - $138,846
Modulation of the migratory dendritic cell tumor-immune microenvironment as a novel treatment for SMARCA4-mutant lung adenocarcinoma using combined anti-ICAM1 and anti-PD-L1 therapies
open$166,800 - $166,800
MRI contrast agents based on iron as alternatives to gadolinium agents.
open$305,253 - $305,253
Leveraging innate immunity for GIST therapy
open$80,020 - $80,020
Deep learning based 3D network biology knowledge portal for precision oncology
open$413,509 - $413,509
HIV persistence and treatment response in Kaposi sarcoma
open$432,098 - $432,098
c-MYB overexpression for exhaustion resistant CAR-T cell therapies
open$400,000 - $400,000
Support of the North American Association of Central Cancer Registries, Inc. (NAACCR) Annual Scientific Conference
open$38,011 - $38,011
Immune drivers of oncogenic virus progression to cancer in people living with HIV
open$544,250 - $544,250
Exploring the dynamic tumor-immune ecosystem of breast cancer in heterogeneous tumor microenvironments
open$531,693 - $531,693
Development of Novel Engineered Native Bacteria (ENB) for the Treatment of Familial Adenomatous Polyposis
open$392,827 - $392,827
Deciphering pathogenesis and therapeutic vulnerabilities in germline RUNX1 mutated AML
open$495,715 - $495,715
CP-CTNet Coordinating Center
open$2,490,206 - $2,490,206
Deep Learning Serial Radiomics for Improved Cancer Therapy Response Assessment.
open$1,686,258 - $1,686,258
Non-invasive etiology-adjusted precision liver cancer risk prediction
open$2,876,456 - $2,876,456
Spotlight on the Cancer Cell: Intrinsic Properties and Vulnerabilities for Therapeutics
open$19,800 - $19,800
Principles of Speckle-Based Gene Regulation
open$1,749,106 - $1,749,106
The role of ENL mutations in kidney development and tumorigenesis
open$49,538 - $49,538
Explainable Analogical Learning for Oncology Diagnosis and Prediction based on Deep Pathophysiology
open$591,468 - $591,468
2025 Hormone-Dependent Cancers Gordon Research Conference and Gordon Research Seminar
open$8,000 - $8,000
Early Integrated Primary and Specialty Palliative Care for Glioblastoma.
open$194,940 - $194,940
Image-guided ethyl cellulose ethanol ablation to enable treatment of cervical dysplasia in low and middle-income countries
open$627,148 - $627,148
The impact of dyadic processes on smoking and cigarette craving: An experimental investigation of romantic partners and smoking friends
open$2,202,321 - $2,202,321
Improving Affordability in Cancer Care through Economic Screening and Support (I-ACCESS)
open$197,747 - $197,747
Determining the function of medium to large diameter sensory neurons in paclitaxel-induced pain via large-scale in vivo DRG imaging
open$2,714,830 - $2,714,830
Image informatics tools for curation and prognostic modeling in pediatric brain tumors
open$398,532 - $398,532
New methods to measure and interrupt metabolic fluxes in brain cancer
open$2,820,337 - $2,820,337
Regulation of tumor suppression by alpha-ketoglutarate
open$990,412 - $990,412
Harnessing natural killer cells for cellular immunotherapy against solid tumors
open$1,457,050 - $1,457,050
Mechanism and therapeutic implication of RNA-modification-mediated codon-biased translation in acute myeloid leukemia
open$941,798 - $941,798
Determining how cancer cachexia influences gluconeogenesis
open$133,955 - $133,955
Cross-talk between social determinants of health and MTOR pathway, the missing link in fatigue
open$427,085 - $427,085
CSHL Course on Methods in Cancer Neuroscience (2025-2029)
open$213,589 - $213,589
Dyadic and social network influences on health and well-being among young adults with cancer
open$197,414 - $197,414
MEDUSA(GM): an analysis platform for resolving mechanisms of action for anti-cancer drugs
open$415,491 - $415,491
Educating Social Workers in Palliative and End of Life Care - Oncology
open$323,327 - $323,327
A dyadic digital skin cancer prevention intervention for adolescents and their parents
open$861,930 - $861,930
Student-Centered Pathway to Advance Research and Cancer Careers
open$324,000 - $324,000
Investigation of the effects of CXCR1/2 inhibition on the immune microenvironment of patients with multiple myeloma
open$173,500 - $173,500
Elucidating and overcoming T cell dysfunction in pancreatic cancer
open$119,858 - $119,858
Improving Engagement with Vaginal Dilator Therapy after Pelvic Radiation: A Pilot Randomized Controlled Trial
open$178,453 - $178,453
Development of NEO212, A Novel Oral Drug for the Treatment of Acute Myeloid Leukemia
open$399,998 - $399,998
High throughput multidimensional chemoproteomics for function-directed covalent target discovery
open$649,181 - $649,181
Characterizing DNA Methylation Dynamics in Trisomy 21-Associated Hematopoiesis and Leukemia
open$462,454 - $462,454
Cancer Associated Development of Education and Training (CADET) Summer Research Experience
open$324,000 - $324,000
Program in Cancer Training and Education (PICTE): Preparing the Next Generation of Scientists and Physicians
open$169,982 - $169,982
Targeted MDM2 degradation for improved treatment for triple-negative breast cancer
open$658,561 - $658,561
Strategically Engineered Multi-Antigen KSHV Vaccine: Integrating Humoral and Cellular Immunity for Effective Protection
open$4,857,475 - $4,857,475
Cancer Risks from Unregulated Contaminants of Public Water Systems
open$376,314 - $376,314
Colonoscopy augmentation with Fluorescence Lifetime Imaging (FLIm): colorectal cancer detection in humans
open$297,074 - $297,074
Enhancing anti-PD-1 blockade antitumor efficacy by oncolytic virotherapy-mediated tumor microenvironment immunomodulation
open$409,158 - $409,158
Discovery Methods for Functional Immune Niches in Cancer
open$421,685 - $421,685
Influence of developmental programming in adult stem cells and cancer
open$621,570 - $621,570
Subclonal determinants of radiation response in soft tissue sarcomas
open$584,521 - $584,521
Unraveling the Role of Microenvironmental Chemokines in Beta-Catenin/TCF Signaling and Gene Occupancy during Colorectal Cancer Metastasis to the Liver and Lung
open$157,980 - $157,980
Microbial-inspired immune-stimulating antibody-toxin conjugate (ATC) for cancer immunotherapy
open$616,715 - $616,715
SBIR Concept award for A novel delivery approach to transform metastatic pancreatic cancer treatment and prevention
open$354,941 - $354,941
The integrated mechanobiology and glycobiology of bone metastasis
open$576,337 - $576,337
Controllable solid tumor immunotherapy based on a wireless thermos-activator
open$3,036,844 - $3,036,844
A System to Support Development and Success of NCI-Sponsored Trials for Rare Diseases
open$122,610 - $122,610
Engineered probiotic bacteria for colorectal cancer immunoprevention and interception
open$727,904 - $727,904
Genome-wide Analysis and Enrichment of Chimeric DNA Fragments in Plasma for Early Detection of Cancer
open$36,756 - $36,756
Generalized and Cancer-Related Episodic Future Thinking for Smoking Cessation: Proof-of-Concept and Feasibility Testing
open$395,248 - $395,248
Targeting extracellular vesicles in neuroblastoma
open$690,013 - $690,013
Health Communications for Adults Smoking Nondaily
open$164,484 - $164,484
Shark Radiotherapy for the Treatment of Triple-Negative Breast Cancer
open$630,171 - $630,171
Molecular Transitions Driving AR Loss in Double Negative Prostate Cancer
open$655,070 - $655,070
A mixed-methods assessment of decisional needs and development of health communication intervention for anal cancer screening among people with HIV
open$181,007 - $181,007
High-throughput and multiplex single-molecule quantification and sorting of single EV
open$625,756 - $625,756
Revolutionizing CAR T-cell Therapy: Enhancing Activity and Persistence of CAR T-cell by Developing a CAR-Enhancer Platform
open$1,340,987 - $1,340,987
Program control of CD8+ T cell response to tumors and tumor memory
open$549,460 - $549,460
Socio-environmental Factors, Accelerated Aging, and Cancer Risks and Outcomes in Middle-Aged and Older Adults
open$386,612 - $386,612
Pilot Feasibility of DESCANSO: Cognitive Behavioral Therapy for Latino Cancer Patients to Treat the Symptom Cluster Depression, Insomnia and Fatigue
open$403,822 - $403,822
Development of Personalized Intact Proteome Map for Ovarian Cancer Patients Using Ultrasensitive Multiplexed Top-down Proteomics
open$631,621 - $631,621
Fluorescence guided nerve sparing during colorectal cancer surgery using local application of a near infrared nerve fluorophore
open$2,491,138 - $2,491,138
Magnetic Resonance Fingerprinting of Glutamate Metabolism for Guiding Glioma Cancer Care
open$3,155,815 - $3,155,815
A randomized trial of charcoal-filtered cigarettes on product perceptions, smoking behaviors, and toxicant exposure
open$687,511 - $687,511
FY25 TASK ORDER D - BASE: WO 126680 B539 EAST BASEMENT SWITCHBOARDREPLACEMENT. OPTION 1: 126680A B539 WEST ATTIC SWITCHBOARDREPLACEMENT
open$1,980,867 - $1,980,867
A Phase 1-2 clinical program for the teatment of Microsatellite Stable Colorectal Cancer with the combination of SR-8541A, Botensilimab, and Balstilimab
open$1,460,952 - $1,460,952
DNA Methylation Markers for early detection and monitoring the trajectory of tumor burden in Bladder Cancer
open$426,828 - $426,828
Elucidating the functional role and therapeutic potential of GPCR kinase 2 in primary and therapy-resistant basal cell carcinoma
open$669,949 - $669,949
Supporting Informed Parental Decisions on HPV Vaccination through Safe and Personalized AI-Driven Conversations
open$2,834,092 - $2,834,092
NextGen Oncology Scholars: Nurturing Tomorrow's Pioneers
open$159,450 - $159,450
ROLE OF RNA SEQUESTRATION IN ACUTE MYELOID LEUKEMIA
open$2,398,360 - $2,398,360
Conversational Agent to Improve Guideline Concordant Care for People with Cervical Cancer Screening Abnormalities
open$3,277,279 - $3,277,279
Mechanisms of genetic and non-genetic resistance to KRAS inhibition
open$607,849 - $607,849
Nanotechnology enabled quantitative imaging of dendritic cell anti-cancer vaccines
open$2,628,974 - $2,628,974
Preclinical studies for the immunoprevention of multiple myeloma
open$704,622 - $704,622
Electronic Communication Between Pediatric Caregivers & Healthcare Teams: impact on perceived quality of care
open$52,538 - $52,538
Quantifying medical exposures to radiation in children with congenital heart defects using advanced Monte Carlo methods and patient-inspired anatomical models
open$45,012 - $45,012
The role of adoptive cellular therapy on myeloid-derived suppressor cell depletion in glioma
open$43,727 - $43,727
Development of a novel, targeted small molecule inhibitor of the nucleoside salvage pathway through combinatorial murine studies to enable further clinical advancement in prostate tumors
open$1,150,000 - $1,150,000
Evaluating an outreach strategy to improve the uptake of shared decision-making for lung cancer screening
open$43,727 - $43,727
Clinical Translation of a Choline-targeted NIR dye to guide lung cancer resection
open$657,168 - $657,168
Extracellular vesicle enclosed circular RNA and interferon responses in tumor host interactions.
open$429,399 - $429,399
Integrated Clinical-Grade genomic and pathology AI biomarkers for high-risk prostate cancer
open$603,981 - $603,981
Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit
open$663,554 - $663,554
Enhancing antitumor efficacy by intratumoral delivering LAIR1 inhibitory signaling
open$394,687 - $394,687
Understanding and Targeting Aberrant RNA Splicing in Leukemia
open$1,034,176 - $1,034,176
Improving Care Delivery for Individuals with Mental Illness and Cancer Across a Cancer Center Network.
open$673,096 - $673,096
Impact of CAR and Nrf2 dual activation on cyclophosphamide bioactivation and doxorubicin detoxification
open$2,840,768 - $2,840,768
The Role and Function of a Novel Signature Gene in BCR::ABL1 (Ph) B-cell Acute Lymphoblastic Leukemia
open$517,090 - $517,090
Integration of circulating tumor cell and nuclear imaging biomarkers to assess LuPSMA response and resistance in advanced prostate cancer patients
open$684,107 - $684,107
InHANCE: Imaging Innovation for Head And Neck Cancer Evaluation & Treatment Delivery
open$64,622 - $64,622
Targeting Myeloid Metabolism to Reprogram the Tumor Microenvironment of Glioblastoma
open$2,467,799 - $2,467,799
Development of the MasSpec Pen Technology to Guide Surgical Decisions in the Care for Patients with Ovarian Cancer
open$697,317 - $697,317
Using germline and somatic genetics to elucidate glioma risk and improve patient outcomes
open$484,803 - $484,803
Hypofractionated radiation in combination with B7-H3-CAR T cells for pediatric patients with relapsed/refractory sarcomas
open$289,937 - $289,937
Targeting the PD-1H (VISTA) Pathway to Overcome Immunosuppression in Acute Myeloid Leukemia
open$449,222 - $449,222
Defining mechanisms of immunotherapy resistance and targeting TIGIT in hepatobiliary cancers
open$270,981 - $270,981
Antidepressant regulation of PDAC
open$677,974 - $677,974
Ratiometric Near-Infrared Probes Utilizing BODIPY Dyes for Viscosity and Protein Aggregation Sensing in Live Cells
open$576,493 - $576,493
Using targeted and non-targeted approaches to examine per- and polyfluoroalkyl substances (PFAS) exposure and glioma risk in young children
open$431,377 - $431,377
GENES WITH SIGNIFICANT DEFICIT OF LOSS-OF-FUNCTION MUTATIONS IN LUNG TUMOR
open$411,404 - $411,404
FY25 FACILITIES TO G CONSTRUCTION OF BMP STRUCTURES FOR MDE STORM-WATER COMPLIANCE
open$2,208,530 - $2,208,530
Persistent Poverty and Colorectal Cancer Risk: Elucidating biological, behavioral, and place-based pathways
open$724,840 - $724,840
Overcoming Resistance to Targeted Therapy in Breast Cancer
open$1,056,000 - $1,056,000
Development of a Personalized Voxel-wise Prediction of Brain Metastases using Multi-Parametric MR Imaging to Reduce Treatment Toxicity
open$729,587 - $729,587
Genetic technology development for elucidating lineage plasticity mechanisms in cancer
open$182,755 - $182,755
Cancer Neuroscience: Crossing Disciplines to Revolutionize Cancer Treatment
open$10,000 - $10,000
The Ecology of Barrett's Esophagus
open$3,130,492 - $3,130,492
DLL3-targeted IL18-secreting CAR T cells in Small Cell Lung Cancer
open$716,521 - $716,521
Predicting trajectories of function, cognition, and quality of life among older adults with advanced lung cancer
open$658,743 - $658,743
Training to Prevent Anal Cancer (TPAC)
open$165,271 - $165,271
HPV Life Cycle and R-loops
open$495,374 - $495,374
Development of nanoscale infrared spectroscopic imaging for measuring cellular ultrastructure
open$573,470 - $573,470
AIDS and Cancer Virus Program (ACVP)
open$13,434,098 - $13,434,098
Informatics Support at FNLCR
open$14,306,292 - $14,306,292
RAS Program at FNL
open$12,458,414 - $12,458,414
Identifying the tissues and tissue features that define the forgiveness window for lenacapavir PrEP in pigtail macaques challenged with HIV
open$732,241 - $732,241
Cryo-EM
open$3,405,122 - $3,405,122
NCI-Frederick Operational Support
open$82,503,495 - $82,503,495
FY26 FFRDC LEASES
open$21,981,436 - $21,981,436
DCCPS - NCCR Data Platform Supplement
open$120,465 - $120,465
Division of Cancer Treatment and Diagnosis- Operational Task Order
open$41,585,966 - $41,585,966
NCI-F Operations and Technical Support II
open$3,683,073 - $3,683,073
DCP - Clinical Trials Regulatory & Monitoring Support for US-Latin American-Caribbean HIV/HPV-Cancer Prevention Clinical Trials Network
open$500,000 - $500,000
DCEG- Genotyping for epidemiology studies
open$5,682,112 - $5,682,112
HPV Serology
open$2,305,845 - $2,305,845
Aire-expressing macrophages as novel mediators of tumor immune evasion
open$677,787 - $677,787
DCP - Clin Trl Info Mgt -DCP Enterprise System Knowledge Base (DESK)
open$640,644 - $640,644
New non-Human Primate to study Sexual transmission of HIV
open$208,809 - $208,809
DCP- Cancer Immunoprevention Laboratory Support
open$2,156,353 - $2,156,353
CGH - Center for Global Health Data Analysis, Technical Support and Dialogues
open$1,100,003 - $1,100,003
DCEG- Molecular Assays for epidemiology studies
open$1,392,004 - $1,392,004
DCP - Biospecimen Processing and Trial Logistics
open$2,855,659 - $2,855,659
Posttranslational regulation of macropinocytosis in pancreatic cancer
open$457,503 - $457,503
DCEG- GWAS Studies
open$1,077,448 - $1,077,448
Tregulatory cell-mediated suppression of tumor elimination by NK cells and CD4 T cells
open$663,340 - $663,340
NIEHS - Lung Microbiome Promotes Emphysema by Activating Lung Innate Immunity
open$25,131 - $25,131
Pre-synaptic events in homologous recombination and maintenance of genomic stability
open$524,815 - $524,815
tRNA modification reprogramming and translational remodeling in cancer
open$922,755 - $922,755
DCEG- Repository Services for epidemiology studies
open$878,502 - $878,502
Simultaneously Targeting Lineage Plasticity and Therapy Resistance Drivers Using a Novel Dual-PROTAC Strategy
open$192,564 - $192,564
Pfn1’s Role in Genomic Stability and Immune Response in Breast Cancer
open$49,538 - $49,538
Co-targeting IGF-1R and Glutaminase in Ewing Sarcoma
open$391,186 - $391,186
Targeting p300/CBP in renal cell carcinoma
open$483,395 - $483,395
Mechanistic studies on the role of GABA type A ion channel (GABAA) receptors in triple negative breast cancer
open$420,600 - $420,600
Biologic rationale of fallopian tube removal to prevent uterine serous carcinoma
open$388,256 - $388,256
Recalibrating the Lung Cancer Policy Model to Address Lung Cancer Risk and Lung Cancer Screening Practices in Real-World Populations
open$429,399 - $429,399
Development of an effective, low-cost, point-of-care early detection test for oral cancer in low resource settings
open$1,021,347 - $1,021,347
Planning Advance Care Together (PACT) to Improve Engagement in Advance Care Planning among Advanced Cancer Patients
open$744,065 - $744,065
Cancer and Developing Entrepreneurial Technologies (CADET)
open$270,624 - $270,624
Defining Intercellular Heterogeneity in Cell Cycle Quiescence
open$627,676 - $627,676
Engaging Impactful Immunotherapy Approaches in Renal Cell Cancer Studies
open$178,893 - $178,893
Links between rRNA and tRNA modifications, codon use, translation, and metabolism in cancer cells
open$953,922 - $953,922
Instituting NCI-funded thyroid and head and neck cancer studies
open$201,870 - $201,870
Enhancing NCI-funded research at the University of Arizona Cancer Center
open$575,051 - $575,051
NCI Research Specialist (Clinician Scientist) Award
open$882,470 - $882,470
Accelerating the expert-crowdsourcing of cancer variant interpretation in CIViC
open$809,106 - $809,106
Advancing Treatment for Head and Neck Cancer Patients with Competing Health Risks through Multi-Center Randomized Trials
open$988,224 - $988,224
A novel ctDNA analysis solution for the next-generation of liquid biopsy assays
open$399,816 - $399,816
Novel Models and Biorepository For Early Detection And Therapeutic Intervention Of Pancreatic Cancer
open$97,305 - $97,305
Computational Genomics and Cloud Computing at El Paso Community College
open$484,764 - $484,764
5mC and 5hmC DNA alterations as sensitive and specific biomarkers for the non-invasive early detection of pancreatic ductal adenocarcinoma
open$690,637 - $690,637
Decoding the Cullin-5 complex to engineer therapeutic T cells with durable effector function
open$680,598 - $680,598
Validation of blood-based biomarkers for risk assessment of lung cancer among individuals with no smoking history in the PLCO Cohort
open$525,013 - $525,013
Preanalytical Validation of Circulating Tumor DNA from Surgical Drain Fluid as a marker of Postoperative Minimal Residual Disease in Head and Neck Squamous Cell Carcinoma
open$360,643 - $360,643
Translational development of osteosarcoma (OS) extracellular vesicle (EV) matrix metalloproteinase (MMP) Activity Assay for assessing patient treatment responses
open$2,097,875 - $2,097,875
A data resource for studying DNA methylation in diverse human tissue types
open$816,623 - $816,623
Cell plasticity in the origin of gastric carcinogenesis
open$2,053,139 - $2,053,139
Flexible versus Standard Aerobic Training Dosing in Primary Breast Cancer: A Randomized and Response-Adapted Trial
open$1,442,297 - $1,442,297
A Path Towards Leveraging AI to Enable Point-of-Care MR Devices for Disease Detection
open$681,215 - $681,215
Simulation, modelling, and estimation of direct and indirect genetic architectures and intergenerational dynamics
open$780,113 - $780,113
Discovering Fusobacterium nucleatum's Impact on Breast Cancer Progression and Treatment with POx Micelle Technology
open$399,829 - $399,829
Dissecting clonal determinants of platinum/PARP inhibitor cross-resistance in ovarian cancer
open$164,000 - $164,000
Developing Multispecific T cell Engaging Therapy for Mixed Phenotype Acute Leukemia
open$434,361 - $434,361
Understanding interplay between the Hsp70 chaperone code and Cyclin D1/Cln3
open$150,784 - $150,784
Advancing Precision Oncology with Scalable Software Solutions for Clinical Variant Interpretation and Expert Curation
open$155,500 - $155,500
Exploring palmitoylation dynamics: impacts on Cadherin-Catenin adhesion and lipid metabolism in the progression of melanoma lung metastasis
open$487,468 - $487,468
Leveraging Radiation-Induced Senescence and PTPN2 Inhibition to Enhance Immune-Mediated Tumor Control in Rectal Cancer
open$730,398 - $730,398
Expanding access and enrollment to precision medicine trials in Acute Myeloid Leukemia
open$135,949 - $135,949
"Charting cellular attraction-based interactome with Multivalent Adhesive Probe AFM (MAPA)"
open$635,749 - $635,749
A prospective study of circulating autoantibodies and breast cancer risk in the NYU Women’s Health Study
open$703,423 - $703,423
Programmable nucleic acid cytometry for unraveling heterogeneity in tumors and therapies
open$418,176 - $418,176
Multiplexed spatially resolved tissue biomarkers for optimal use of PD-1 axis blockers and PARP inhibitors in cancer.
open$251,360 - $251,360
Point of care diagnostic to improve access to gynecological screening in low-resource settings
open$400,000 - $400,000
Flow-informed therapy for glioblastoma
open$522,491 - $522,491
AI-powered engineering and analysis of cyanobacterium vesicles targeting gastrointestinal cancer
open$400,000 - $400,000
Developing a Certificate in Computational Genomics and Biomedical Data Science
open$486,000 - $486,000
Validation, translation, and clinical implementation of a gene expression biomarker to predict meningioma outcomes and radiotherapy responses
open$315,066 - $315,066
Transforming Mammography With STARLIGHT, Imagine Scientific's Monochromatic X-Ray Imaging System
open$779,658 - $779,658
Understanding omega-3 and 6 fatty acid dependent regulation of inflammatory signals in pancreatic cancer
open$745,320 - $745,320
The BRCA Exchange Knowledgebase for Clinical Cancer Genetics
open$660,079 - $660,079
Functional signatures of post-infusion CAR T cells for early indication of patient response
open$399,625 - $399,625
Single-cell (phospho-)proteomics platform for functional analysis of tumor microenvironment
open$450,904 - $450,904
An Integrated Curriculum that Supports Genomic Data Education
open$483,620 - $483,620
Cancer Immunoprevention Network (CIP-Net) Resource Coordinating Center
open$825,857 - $825,857
Stiffness-mediated genetic selection of cells
open$556,865 - $556,865
Efficient, cost-effective, and ultrasensitive sequencing of somatic mutations and methylation
open$369,468 - $369,468
FULL PROJECT 1 - Circulating Immune Cell Profiles, Immune Biomarkers and Lung Cancer Risk
open$112,808 - $112,808
The role of adverse social-biological interactions in acute myeloid leukemia disparities
open$726,828 - $726,828
Translating Insights in Follicular Lymphoma for Improved Diagnosis and Classification
open$714,110 - $714,110
PILOT PROJECT 2: Understanding the biology of an ADCK4-NUMBL fusion in lung adenocarcinoma aggressiveness
open$144,604 - $144,604
Mechanistic Dissection and Modulation of Cytoskeletal Regulation to Overcome Innate Resistance to KRAS Inhibition
open$375,150 - $375,150
A Role for the Novel HAF-NFkappaB Axis in Driving Obesity-Associated Liver Cancer
open$858,089 - $858,089
AI for Differentiation of Low vs High Risk Thyroid Nodules on Ultrasound
open$2,867,231 - $2,867,231
Exploiting Homologous Recombination Defects with a Novel DNA-Crosslinking Strategy
open$49,538 - $49,538
Evaluating the Interplay of Structural, Social, and Spatial Factors in Ovarian Cancer Survival Disparities in California
open$44,826 - $44,826
The oncogenic roles of alarmins and monocytes in triple negative myelofibrosis
open$157,248 - $157,248
The role of genetic and epigenetic variation in the progression of IDH mutant gliomas
open$169,884 - $169,884
Chimeric Antigen Receptor Modified Natural Killer Cells for the Treatment of Solid Tumors
open$192,564 - $192,564
CD4+ T Cell Activating Hydrogels for Cancer Immunotherapy
open$49,538 - $49,538
The Role of Treg and Tpex Interactions in Tumor-Draining Lymph Node Immunosuppression and Immunotherapy Response
open$40,513 - $40,513
Neutrophil-driven pro-recurrent niche formation in mammary adipose tissue
open$49,538 - $49,538
Investigating the role of OAADPr-ACADM interaction in colorectal cancer
open$46,462 - $46,462
Reprogramming myeloid cells by JAK inhibition to enhance checkpoint blockade therapy
open$183,600 - $183,600
Extrachromosomal DNA as a driver of heterogeneity and plasticity in glioblastoma
open$48,515 - $48,515
The impact of aberrant m5C mRNA modification on translation initiation and cancer
open$75,052 - $75,052
Interrogating Mechanisms of Suppressed Tpex Immunotherapy Response in Metastatic Tumor-Draining Lymph Nodes
open$42,057 - $42,057
Early detection of cancer using extracellular vesicle-based liquid biopsy enhanced by priming agents
open$54,538 - $54,538
UCCC P30 Supplement: Human Endogenous Retrovirus-H as a Target for Early-Onset Colorectal Cancer
open$156,000 - $156,000
NCI Research Specialist (Clinician Scientist) Award for Improving Cancer Screening and Clinical Trial Enrollment
open$361,695 - $361,695
Project-3: Targeting Hedgehog Signaling Pathway in Breast Cancer Therapy
open$146,725 - $146,725
Transcriptomic classification of non-muscle invasive bladder cancer and its clinical and prognostic implication
open$2,683,351 - $2,683,351
Quit4Life+: Adapting and Evaluating a Phone-Based Tobacco Use Cessation Program for People Living with HIV in Uganda and Zambia
open$410,433 - $410,433
Analytical and Clinical Validation of an H3K27M ctDNA Assay for Diffuse Midline Glioma (DMG) Surveillance
open$210,600 - $210,600
A randomized trial of cardioprotective strategies in newly diagnosed diffuse large B-cell lymphoma and pre-existing cardiomyopathy or prior anthracycline exposure
open$818,625 - $818,625
RNA Processing in Cancer: From Bench to Bedside
open$15,000 - $15,000
Investigating the Effect of Caspases and Anti-Viral Responses on KSHV Tumorigeniesis
open$216,013 - $216,013
Development of new Pt-based ROS storm inducing polymers with tumor specific toxicity
open$403,485 - $403,485
NMR strategies to probe allosteric effects of inhibitor binding on AML-associated Src-family kinases
open$151,920 - $151,920
pA-regulator controlled, JMJD6 reprogrammed GPC3-CAR T cells for patients with hepatocellular carcinoma
open$470,759 - $470,759
Dissecting the structure-function relationship of the Wnt destruction complex condensate
open$402,400 - $402,400
Advancing Extracellular Vesicle Therapy for Brain Cancer
open$305,031 - $305,031
Molecular Screening for Human Papilloma Virus (HPV) Associated with Cervical Cancers in LMIC Environments
open$306,872 - $306,872
Overcoming Immune Checkpoint Blockade Resistance in Glioblastoma with a Novel Stem Cell Biotherapeutic
open$276,544 - $276,544
Determining the role of nuclear integrity loss surveillance in PARPi-inducedcell death in BRCA1-deficient cancer
open$49,538 - $49,538
A Tailored Medication Adherence-Promotion Intervention for Adolescents and Young Adults with Cancer
open$763,161 - $763,161
Investigating and targeting NSD2 mutation-driven leukemia transformation
open$484,405 - $484,405
Clinical Trials Specialist in NCI Clinical Trials Research
open$193,926 - $193,926
Preparing IND filing for novel lung cancer therapeutic
open$249,815 - $249,815
Development and piloting of an intervention to reduce the impact of opioid stigma in cancer pain
open$145,746 - $145,746
CHD1Li Targeted Combinations with Chemotherapy to Address Unmet Needs in Colorectal Cancer Treatment
open$400,000 - $400,000
System for Malignant Lymph Node Identification
open$306,798 - $306,798
Discovery of the mechanisms governing Natural Killer T-cell activation and therapeutic potential in cancer
open$39,113 - $39,113
Developing methods for advancing the early detection of pancreatic ductal adenocarcinoma leveraging electronic medical records data
open$739,640 - $739,640
Tumor suppressor vulnerability conferred by aneuploid loss of haploinsufficient metallothionein genes
open$906,000 - $906,000
TYK2 Fusions in Lymphoma
open$3,111,184 - $3,111,184
PRSS1 Mutation and Pancreatic Cancer Tumorigenesis
open$850,552 - $850,552
Initiation of Diffuse and Intestinal Non-Cardia Gastric Cancer
open$98,559 - $98,559
Connectivity mapping identified novel combination therapy for glioblastoma
open$891,835 - $891,835
Bioethics research to understand engagement in decision-making among adolescents and young adults with cancer at risk for health care disparities
open$178,000 - $178,000
CAR T cells targeting mesothelin and secreting bispecific antibodies targeting fibroblasts in pancreatic cancer
open$2,054,733 - $2,054,733
Regulation of PDAC metabolism and immunity by collagen and its cleavage products
open$1,152,768 - $1,152,768
Building a Systems Immunopeptidomics Framework to Challenge the Current T Cell Activation Paradigm
open$1,512,500 - $1,512,500
Early-Life Enterotoxigenic Bacteroides fragilis Acquisition and Colorectal Cancer Risk
open$83,224 - $83,224
Understanding eosinophilic esophagitis-mediated inhibition of esophageal cancer
open$36,264 - $36,264
Assessing feasibility and acceptability of a multifaceted EHR-integrated mobile health intervention following radical cystectomy
open$682,272 - $682,272
New approaches to targeting cell cycle proteins for cancer treatment
open$855,249 - $855,249
Fluorescent Biosensors for measuring the signaling kinetics of GPCR ligands that activate G12/13 pathways.
open$364,367 - $364,367
Precision single-cell mapping of chromatin-associated protein activity by molecular footprinting to chart disruptions to gene regulation and dissect tumor heterogeneity in cancer
open$401,829 - $401,829
Electrical impedance myography (EIM) to detect and track cancer cachexia
open$263,052 - $263,052
Gastroesophageal junction stem cells as the origin of Barretts esophagus and cancer
open$1,944,000 - $1,944,000
Development of Second Generation BLVRB Inhibitors for Treating Chemotherapy Induced Thrombocytopenia
open$400,000 - $400,000
Proposal for NCI Research Specialist (Clinician Scientist) Award
open$375,025 - $375,025
Dissecting the Functional Role of PAX5 Mutations in B-cell Acute Lymphoblastic Leukemia
open$483,110 - $483,110
Biological factors driving clinical outcomes in HPV+ oropharyngeal cancer
open$510,650 - $510,650
Administrative Supplement to Cancer Center Support Grant (CCSG)
open$194,998 - $194,998
Next generation T cell therapies for mutant KRAS solid tumors
open$2,238,704 - $2,238,704
2025 Cancer Cachexia Conference: Cachexia management today and potential treatments for tomorrow
open$35,000 - $35,000
Develop a novel multi-approach dynamic Spot Scanning Proton Arc optimization framework
open$498,372 - $498,372
Etiology and Tumor Characteristics of Early-onset Pancreatic Cancer
open$191,700 - $191,700
Evaluation of Cardiovascular Health Outcomes among Survivors 2 (ECHOS-2)
open$772,418 - $772,418
Harnessing big data to understand the confluence of HIV and cancer stigma in the US Southeast
open$851,463 - $851,463
Effectiveness and implementation of a decision support tool to improve surgical decision making in young women with breast cancer
open$1,215,184 - $1,215,184
AI algorithm development for cervical cancer screening in low resource settings
open$371,161 - $371,161
Exploring anti-sense RNAs in melanocyte transformation and melanoma formation
open$433,256 - $433,256
Dual localization of angiopoietin like protein 4 in the extracellular milieu and nucleus regulates the hematogenous brain metastasis of triple negative breast cancer
open$408,259 - $408,259
Defining the role of histone H3K4 mono-methyltransferase dysfunction in urothelial carcinoma
open$1,204,605 - $1,204,605
Deciphering novel UPS regulation of Sgf73/ataxin-7 in controlling SAGA and associated functions in gene expression
open$445,500 - $445,500
Elucidating the interplay between H3K27M variants and DNA damage repair in diffuse midline glioma
open$42,480 - $42,480
Conditional Agonism: PD1-Dependent Activation of 4-1BB for Enhanced Safety
open$153,959 - $153,959
Biological and clinical significance of spatial immune heterogenenity in non-small cell lung cancer
open$478,532 - $478,532
Translating the tumor regulome from cell-free DNA for precision oncology
open$1,056,000 - $1,056,000
Decoding the regulation and function of GZMK within tumor-infiltrating CD8+ T cells
open$42,480 - $42,480
Modified Thrombin Binding Aptamer Treatment of CRC Metastasis
open$399,968 - $399,968
Modulating costimulation in CAR T cells to enhance antitumor efficacy
open$35,090 - $35,090
The role of loss of Y chromosome across the prostate cancer continuum
open$129,058 - $129,058
Accelerating Bioengineering Approaches for Increasing Access to New Solutions Targeting Breast Cancer Reconstructive Surgery
open$356,500 - $356,500
Elucidating the role of type 2 conventional dendritic cells in shaping anti-tumor immunity
open$49,538 - $49,538
Biomarker discovery in colon cancer through next-generation metabolomics
open$881,647 - $881,647
Direct activation of STAT5 to improve T cell therapeutics
open$42,545 - $42,545
Engineered Living Materials as Programmable Therapeutic Implants for Pancreatic Cancer
open$137,995 - $137,995
The role of SUV39H1 in maintaining heterochromatin architecture and identity in Acute Myeloid Leukemia
open$44,751 - $44,751
Immuno-modulating Diffuse Midline Glioma by Epi-transcriptomic Reprogramming
open$54,538 - $54,538
Investigating evolutionary antagonism between tumors and lymphocytes
open$49,538 - $49,538
Engineering diverse commensal skin bacteria for targeted immunotherapy
open$443,564 - $443,564
Immune Evasion through HLA-E in Diffuse Large B-Cell Lymphoma: Defining Its Regulation and Cellular Interactions
open$241,884 - $241,884
Transforming prostate cancer diagnosis: Feasibility testing of a novel system for integrated endorectal MRI and in-bore biopsy
open$399,995 - $399,995
Mutation specific pan-KRAS inhibitor signaling responses and anti-tumor effect
open$188,351 - $188,351
DLK1 as a novel target for Down syndrome myeloid leukemia
open$1,273,073 - $1,273,073
Implementation science to scale and sustain tobacco treatment leveraging point of care paradigm and health information technology
open$1,594,797 - $1,594,797
Illuminating the subcellular localization and regulation of D-2-hydroxyglutarate using a novel genetically encoded fluorescent biosensor
open$462,153 - $462,153
Characterization of HIO-2, a tumor-produced protein that inhibits therapeutic antibody-mediated cellular cytotoxicity via Fc Receptor (CD16a) blockade
open$115,000 - $115,000
FY25 FACILITIES TO E - 126663 B539 MISC SAFETY UPGRADES
open$1,676,963 - $1,676,963
Leveraging Nanoparticle Interactions with Host Immune Cells to Detect and Treat Cancer
open$144,193 - $144,193
Using Vagal Nerve Stimulation in Conjunction with NRT for Smoking Cessation
open$411,939 - $411,939
Enhancing access in breast cancer prevention clinical trials
open$135,951 - $135,951
RISE: Reducing Cancer and HIV Stigma through Empowerment
open$24,894 - $24,894
SCH: Graph-String Transformer and Reinforcement Learning for Design of Cancer Theranostics
open$300,001 - $300,001
Early-life exposures to extreme weather-related factors and pediatric thyroid cancer risk
open$431,386 - $431,386
SCH: Wireless sensing of biomarkers using intelligent surfaces for smart homes and sleep medicine
open$974,377 - $974,377
SBIR CONCEPT AWARD FOR DEVELOPMENT OF THERAPEUTIC OR PREVENTATIVE TECHNOLOGIES FOR TREATMENT OR PREVENTION OF PEDIATRIC CANCERS AND/OR RARE CANCERS
open$354,957 - $354,957
Translation of Evolved Oncolytic Virotherapy Product for Colorectal Cancer Treatment
open$306,871 - $306,871
CSHL 2025 Conference on Biology of Cancer: Microenvironment and Metastasis
open$30,000 - $30,000
DIRECT TO PHASE II SBIR CONCEPT AWARD FOR NOVEL IONTOPHORETIC DRUG DELIVERY DEVICE FOR LOCAL AND EFFECTIVE TREATMENT OF ORAL CANCER
open$2,995,581 - $2,995,581
Therapeutic targeting and biophysical characterization of CAR-mediated trogocytosis
open$422,799 - $422,799
Development of deazaflavin analogs as potent and selective MRP1 inhibitors for cancer chemosensitization
open$395,973 - $395,973
Extensions of the SEER-Medicare database: A Critical Opportunity to Answer Real World Questions about the Delivery of High Quality Cancer Care
open$130,301 - $130,301
Elucidating the role of PATZ1 in MYCN-amplified neuroblastoma
open$78,040 - $78,040
SBIR TOPIC: DEVELOPMENT OF DEVICES, DIAGNOSTIC TECHNOLOGIES, OR DIGITAL HEALTH TOOLS FOR TREATMENT, DETECTION, AND DIAGNOSIS OF PEDIATRIC CANCERS AND/OR RARE CANCERSPHASE I CONCEPT TITLE: EVALUATING
open$506,498 - $506,498
Development of a novel, targeted small molecule inhibitor of the nucleoside salvage pathway through murine studies to enable further clinical advancement in non-small-cell lung cancer
open$406,500 - $406,500
Evaluate the role of extracellular vesicles in tumor microenvironment modulation
open$148,500 - $148,500
Adaptation and Implementation of an Evidence-Based Patient Navigation Intervention for Adolescent and Young Adult Cancer Survivors
open$703,321 - $703,321
Rare Tumor Clinical Research Specialist
open$197,518 - $197,518
Noncovalent interaction of mutant KRAS inhibitors
open$411,152 - $411,152
Brilliant epitopes for improved cancer vaccines
open$405,599 - $405,599
Immunomodulatory AVM0703 to bridge Relapsed/Refractory Diffuse Large B-Cell Lymphoma patients to CAR-T cell immunotherapy
open$992,425 - $992,425
Facilitating Scale-Up and Sustainment of High-Quality Lung Cancer Screening Using the QUILS System
open$1,549,462 - $1,549,462
Defining a globally accessible and pragmatic predictive signature (GAPPS) for locally advanced cervical cancer
open$498,565 - $498,565
Targeting cancer metastasis by inhibiting curvature-induced kinase activation
open$1,033,055 - $1,033,055
A Pilot Study to Correlate 4-[18F]fluoro-1-naphthol PET/CT Imaging with Chronic Graft Versus Host Disease Manifestations
open$358,605 - $358,605
Patient-directed technology for non-pharmacologic management of cancer pain
open$404,295 - $404,295
Efficient Measurement and Characterization of Genetic Interactions in Cancer Cells
open$370,173 - $370,173
Glyco-MAP: a high-throughput multiplexed platform for Glycosylated Mucin Antibody Profiling with glycoengineered cell lines expressing well-defined homogeneous glycostructures
open$183,494 - $183,494
Rapid inter-procedural 3D scanning of fine-needle aspiration cytology slides with a parallelized microscope
open$306,872 - $306,872
Deciphering the role of cancer pain-associated neuronal activity in driving malignancies
open$513,127 - $513,127
Novel Telomere-Targeting Therapy for Advanced Non-Small Cell Lung Cancer
open$770,168 - $770,168
Targeted Delivery of Tumor Antigen esaRNA to the Spleen for Cancer Immunotherapy
open$399,300 - $399,300
Preclinical development of a tandem CART / HSC transplantation platform for hematologic malignancies
open$399,739 - $399,739
Understanding and Exploiting Loss of Y in Cancer
open$930,500 - $930,500
Understanding and Harnessing Microbial Reprogramming to Combat Carcinogenic Colibactin in Colorectal Cancer
open$2,864,671 - $2,864,671
Leveraging Omics and Electronic Health Records Data to study Colorectal Adenoma genetics and Drug Repurposing
open$4,174,595 - $4,174,595
Expanding access to perioperative and repurposed drug trials in melanoma and other solid tumors
open$83,925 - $83,925
Maximizing GlyTR pan-cancer immunotherapy by enhancing target density
open$463,510 - $463,510
Patient Navigation for Improving Transition Success Among Multiply Disadvantaged Young Adult Survivors of Childhood Cancer
open$4,236,812 - $4,236,812
Determining immune-mediated mechanisms of beneficial bacteria in colon cancer
open$201,960 - $201,960
Promoting Lead Academic Participating Sites (LAPS) Studies Accrual and Lung cancer Screening in Oklahoma
open$424,480 - $424,480
NeuroAccess: a Focused Ultrasound System for SonoBiopsy of the Brain
open$999,125 - $999,125
Evaluating the adoption, implementation, and maintenance of a cervical precancer treatment in El Salvador
open$183,835 - $183,835
Unraveling the Impact of Extracellular Vesicle-Loaded FXR1 mRNA on Re-educating Cancer Microenvironment
open$494,160 - $494,160
Targeting Polyamine Metabolism in Relapsed Acute Myeloid Leukemia Stem Cells
open$530,106 - $530,106
Feasibility of cue-based treatment intervention to promote cessation among people who smoke lightly (<=10 cigarettes per day) or non-daily
open$906,306 - $906,306
Development of high parameter spatial transcriptomics and proteomics for the study of tumor microenvironments
open$584,510 - $584,510
Differential activation of the triacylglycerol pathway in lipofibroblasts induces neurogenesis associated with prostate cancer progression
open$1,575,170 - $1,575,170
Thriving Beyond Treatment: A Resilience-Based Approach to Improve Long-term Quality of Life in Post-treatment Lymphoma Survivorship
open$817,829 - $817,829
Trainee Symposium for IDeA state trainees
open$50,000 - $50,000
HLA LOH Detection via Liquid Biopsy: A Blood-Based Predictive Biomarker Assay for Precision Immuno-Oncology
open$406,500 - $406,500
Focal Adhesion Kinase inhibition for dual targeting of osteosarcoma cells and the tumor microenvironment to prevent metastasis
open$629,341 - $629,341
Scanner Agnostic Image-Guided Biopsy Platform Employing Advanced Computer Vision and Computer Graphics to Enable Non-Invasive Registration and Dynamic Projection Mapping
open$1,107,943 - $1,107,943
Spatiomolecular Profiling of Human Cancer at Scale
open$372,628 - $372,628
Accurate Detection of Early-Stage Pancreatic Tumors using Artificial Intelligence Analysis of Abdominal Computed Tomography Scans
open$523,670 - $523,670
Expanding Lung Cancer Screening to Achieve Excellence (EXHALE)
open$1,684,165 - $1,684,165
Elucidating pathways underlying the association of contraception use with ovarian cancers through metabolic profiling
open$155,605 - $155,605
Catalyzing cancer research through the use of advanced functional genomics and cell engineering technologies
open$491,315 - $491,315
Development of MM010, a PEG-specific intervention that blocks allergic response and restores effective repeat dosing of peg-asparaginase in patients with acute lymphoblastic leukemia
open$409,732 - $409,732
Efforts to Discover Novel Therapies and Reduce Treatment Toxicities for Lymphoma and Chronic Lymphocytic Leukemia Patients Through Collaboration and the NCTN
open$935,075 - $935,075
Logic Gated Precision Molecular Adaptor System for Juvenile Myelomonocytic Leukemia Treatment
open$499,990 - $499,990
DNA, RNA, and Chromatin Epigenetics: Disease and Development
open$10,000 - $10,000
Remotely-Delivered Cognitive Behavioral Stress Management Effects on Cancer-Accelerated Aging in Older, Distressed Breast Cancer Survivors
open$2,746,080 - $2,746,080
Genomic correlates of outcome in pleuropulmonary blastoma
open$528,902 - $528,902
Inhibitors of ENPP1 for the treatment of hepatocellular carcinoma
open$306,739 - $306,739
PRODUCING USHER III RETINAL ORGANOIDS FROM PATIENT CELLS TO MEASURE THE EFFECT OF DRUG CANDIDATE
open$794,843 - $794,843
SBIR FY25 Concept Award: Development of engineered tRNA therapeutics for Clear Cell Renal Cell Carcinoma
open$355,000 - $355,000
TUMOR-DERIVED EXTRACELLULAR VESICLES FOR DIAGNOSIS OF EARLY-STAGE OVARIAN CANCER
open$354,828 - $354,828
EVALUATION OF IVO COMPOUNDS IN BLEOMYCIN-INDUCED PULMONARY FIBROSIS MODEL
open$219,752 - $219,752
DEVELOP, QUALIFY IMMUNOLOGICAL ASSAYS, AND PROVIDE CLINICAL SAMPLE TESTING FOR AAV-BASED GENE THERAPY CLINICAL CANDIDATES
open$2,510,508 - $2,510,508
A Novel Lentivector for Enhanced In Vivo Delivery of T Cell Receptors for Cell Therapy for Stage IV Melanoma
open$400,000 - $400,000
SBIR FY25 CONCEPT AWARD: TARGETING DYSFUNCTIONAL CHROMATIN NETWORKS IN DIPG
open$355,000 - $355,000
MANUFACTURING PROCESS DEVELOPMENT OF 4-HB
open$917,706 - $917,706
STABILITY STUDY SUPPORT OF R-VK4-116
open$98,473 - $98,473
Modeling Enhancer Hijacking in Cancer via Genome Engineering and Single-Cell Sequencing
open$194,914 - $194,914
Assessing the impact of the substantial equivalence mechanism on the cigarette and cigar markets
open$816,307 - $816,307
Increasing Lung cancer screening Effectiveness and Access through Regional Networks (I-LEARN)
open$1,593,217 - $1,593,217
Minimally invasive pancreatic cancer treatment combining nanosecond electric pulses and immune system stimulants
open$303,475 - $303,475
NOVEL THERANOSTIC RADIOLIGANDS TARGETING DISEASE-SPECIFIC EXTRACELLULAR MATRIX COMPONENTS SPECIFIC TO TUMOR AND METASTATIC LESIONS IN PATIENTS SUFFERING FROM HEREDITARY BREAST AND OVARIAN CANCER (HBOC
open$354,456 - $354,456
Funder Overview
Total Opportunities1000
Grants1000
Contracts0
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